醫學科學研究所

  • No. 250 Wu-Xing Street

    11031 Taipei

研究成果 1994 2020

2020

Mammalian target of rapamycin and p70S6K mediate thrombin-induced nuclear factor-κB activation and IL-8/CXCL8 release in human lung epithelial cells

Lin, C. H., Shih, C. H., Jiang, C. P., Wen, H. C., Cheng, W. H. & Chen, B. C., 二月 5 2020, 於 : European Journal of Pharmacology. 868, 172879.

研究成果: 雜誌貢獻文章

Complement Factor B
Sirolimus
Interleukin-8
Thrombin
Phosphotransferases
2019

A critical period for the development of schizophrenia-like pathology by aberrant postnatal neurogenesis

Sheu, J. R., Hsieh, C. Y., Jayakumar, T., Tseng, M. F., Lee, H. N., Huang, S. W., Manubolu, M. & Yang, C. H., 一月 1 2019, 於 : Frontiers in Neuroscience. 13, JUN, 635.

研究成果: 雜誌貢獻文章

開啟存取
Neurogenesis
Schizophrenia
Pathology
Critical Period (Psychology)
Hallucinations
Curcumin
Endothelin-1
Fibroblasts
Thrombin
Phosphotransferases

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Shen, T. J., Jhan, M. K., Kao, J. C., Ho, M. R., Tsai, T. T., Tseng, P-C., Wang, Y. T. & Lin, C-F., 2019, 於 : Journal of Visualized Experiments.

研究成果: 雜誌貢獻文章

Viral Encephalitis
Dengue Virus
Viruses
Severe Dengue
Arboviruses
開啟存取
Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Radiation Tolerance
Autophagy
Proteins

Angiotensin-converting enzyme inhibitors or angiotensin receptor blocker monotherapy retard deterioration of renal function in Taiwanese chronic kidney disease population

Zheng, C. M., Wang, J. Y., Chen, T. T., Wu, Y. C., Wu, Y. L., Lin, H. T., Chiu, S. P., Chang, T. J., Zheng, J. Q., Chu, N. F., Lin, Y. M., Su, S. L., Lu, K. C., Chen, J. S., Sung, F. C., Lee, C. T., Yang, Y., Hwang, S. J., Wang, M. C., Hsu, Y. H. 及其他4, Chiou, H. Y., Kao, S., Wu, M. Y. & Lin, Y. F., 十二月 1 2019, 於 : Scientific Reports. 9, 1, 2694.

研究成果: 雜誌貢獻文章

開啟存取
Angiotensin Receptor Antagonists
Chronic Renal Insufficiency
Angiotensin-Converting Enzyme Inhibitors
Angiotensins
Kidney
12 引文 (Scopus)

A novel injectable in situ forming gel based on carboxymethyl hexanoyl chitosan/hyaluronic acid polymer blending for sustained release of berberine

Lu, K. Y., Lin, Y. C., Lu, H. T., Ho, Y. C., Weng, S. C., Tsai, M. L. & Mi, F. L., 二月 15 2019, 於 : Carbohydrate Polymers. 206, p. 664-673 10 p.

研究成果: 雜誌貢獻文章

Berberine
Hyaluronic acid
Hyaluronic Acid
Chitosan
Polymers
Single-Chain Antibodies
Epitopes
Escherichia coli
Amino Acids
OMPA outer membrane proteins

Author Correction: The choroid plexus is an important circadian clock component (Nature Communications, (2018), 9, 1, (1062), 10.1038/s41467-018-03507-2)

Myung, J., Schmal, C., Hong, S., Tsukizawa, Y., Rose, P., Zhang, Y., Holtzman, M. J., De Schutter, E., Herzel, H., Bordyugov, G. & Takumi, T., 十二月 1 2019, 於 : Nature Communications. 10, 1, 5253.

研究成果: 雜誌貢獻評論/辯論

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document markup languages
Circadian Clocks
HTML
Choroid Plexus
clocks

Biocompatibility and osteogenic capacity of Mg-Zn-Ca Bulk metallic glass for rabbit tendon-bone interference fixation

Wong, C. C., Wong, P. C., Tsai, P. H., Jang, J. S. C., Cheng, C. K., Chen, H. H. & Chen, C. H., 五月 3 2019, 於 : International Journal of Molecular Sciences. 20, 9, 2191.

研究成果: 雜誌貢獻文章

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tendons
Tendons
rabbits
Metallic glass
biocompatibility

Biomechanical and tomographic differences in the microarchitecture and strength of trabecular and cortical bone in the early stage of male osteoporosis

Yeh, P. S., Lee, Y. W., Chang, W. H., Wang, W., Wang, J. L., Liu, S. H. & Chen, R. M., 一月 1 2019, 於 : PLoS ONE. 14, 8, e0219718.

研究成果: 雜誌貢獻文章

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Orchiectomy
osteoporosis
Osteoporosis
Bone
bones
3 引文 (Scopus)

Cardamonin Induces Cell Cycle Arrest, Apoptosis and Alters Apoptosis Associated Gene Expression in WEHI-3 Mouse Leukemia Cells

Liao, N-C., Shih, Y-L., Chou, J-S., Chen, K-W., Chen, Y-L., Lee, M-H., Peng, S-F., Leu, S-J. & Chung, J-G., 四月 25 2019, 於 : The American journal of Chinese medicine. p. 1-22 22 p.

研究成果: 雜誌貢獻文章

Cell Cycle Checkpoints
Leukemia
Apoptosis
Gene Expression
Apoptosis Regulatory Proteins
1 引文 (Scopus)

Chemovirotherapeutic Treatment Using Camptothecin Enhances Oncolytic Measles Virus-Mediated Killing of Breast Cancer Cells

Tai, C. J., Liu, C. H., Pan, Y. C., Wong, S. H., Tai, C. J., Richardson, C. D. & Lin, L. T., 十二月 1 2019, 於 : Scientific Reports. 9, 1, 6767.

研究成果: 雜誌貢獻文章

開啟存取
Oncolytic Viruses
Camptothecin
Measles virus
Breast Neoplasms
Therapeutics
開啟存取
vitamin K deficiency
Vitamin K Deficiency
Vascular Calcification
vitamin K
Vitamin K
開啟存取
Aquaporin 1
Caveolin 1
Brain Edema
Gold
Nanoparticles
3 引文 (Scopus)
temozolomide
Dehydroepiandrosterone
Glioblastoma
Acetylation
Phosphorylation
MicroRNAs
Squamous Cell Carcinoma
Melanoma
Neoplasms
Reverse Transcription
3 引文 (Scopus)

DNA primase polypeptide 1 (PRIM1) involves in estrogen-induced breast cancer formation through activation of the G2/M cell cycle checkpoint

Lee, W-H., Chen, L-C., Lee, C-J., Huang, C-C., Ho, Y-S., Yang, P-S., Ho, C-T., Chang, H-L., Lin, I-H., Chang, H-W., Liu, Y-R., Wu, C-H. & Tu, S-H., 二月 1 2019, 於 : International Journal of Cancer. 144, 3, p. 615-630 16 p.

研究成果: 雜誌貢獻文章

DNA Primase
G2 Phase Cell Cycle Checkpoints
Estrogens
Breast Neoplasms
Peptides

DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation

Lai, S. C., Su, Y. T., Chi, C. C., Kuo, Y. C., Lee, K. F., Wu, Y. C., Lan, P. C., Yang, M. H., Chang, T. S. & Huang, Y. H., 十一月 26 2019, 於 : Journal of Experimental and Clinical Cancer Research. 38, 1, 474.

研究成果: 雜誌貢獻文章

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Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling

Tsai, C. H., Lee, Y., Li, C. H., Cheng, Y. W. & Kang, J. J., 一月 1 2019, (接受/付印) 於 : Cell Biology and Toxicology.

研究成果: 雜誌貢獻文章

Aryl Hydrocarbon Receptors
STAT3 Transcription Factor
Carcinogens
Down-Regulation
Cytokines
Embryonal Carcinoma Stem Cells
Neural Stem Cells
Zinc Fingers
Transcription
Zinc
2 引文 (Scopus)

Emerging role of vitamins d and k in modulating uremic vascular calcification: The aspect of passive calcification

Hs, Y. C., Lu, C. L., Zheng, C. M., Chen, R. M., Lin, Y. F., Liu, W. C., Yen, T. H., Chen, R. & Lu, K. C., 一月 1 2019, 於 : Nutrients. 11, 1

研究成果: 雜誌貢獻回顧型文獻

Vascular Calcification
calcification
blood vessels
Vitamins
vitamins

Enterobius vermicularis infection: Prevalence and risk factors among preschool children in kindergarten in the capital area, Republic of the Marshall Islands

Fan, C. K., Chuang, T. W., Huang, Y. C., Yin, A. W., Chou, C. M., Hsu, Y. T., Kios, R., Hsu, S. L., Wang, Y. T., Wu, M. S., Lin, J. W., Briand, K. & Tu, C. Y., 六月 18 2019, 於 : BMC Infectious Diseases. 19, 1, 536.

研究成果: 雜誌貢獻文章

開啟存取
Enterobiasis
Micronesia
Enterobius
Preschool Children
Economics

Folic acid inhibits colorectal cancer cell migration

Ting, P. C., Lee, W. R., Huo, Y. N., Hsu, S. P. & Lee, W. S., 一月 1 2019, 於 : Journal of Nutritional Biochemistry. 63, p. 157-164 8 p.

研究成果: 雜誌貢獻文章

Folic Acid
Cell Movement
Colorectal Neoplasms
Cells
Cell proliferation
Ionizing radiation
Ionizing Radiation
Interferons
Cytotoxicity
STAT1 Transcription Factor
3 引文 (Scopus)

Functional neutralization of anti-IFN-γ autoantibody in patients with nontuberculous mycobacteria infection

Krisnawati, D. I., Liu, Y. C., Lee, Y. J., Wang, Y. T., Chen, C. L., Tseng, P. C. & Lin, C. F., 四月 5 2019, 於 : Scientific Reports. 9, 1, p. 5682 5682.

研究成果: 雜誌貢獻文章

開啟存取
Nontuberculous Mycobacterium Infections
Autoantibodies
Interferons
Serum
Chemokines
1 引文 (Scopus)
Neurogenesis
Neurons
Stroke
Recovery
Patient rehabilitation

HECT E3 Ubiquitin Ligase-Regulated Txnip Degradation Facilitates TLR2-Mediated Inflammation During Group A Streptococcal Infection

Tseng, P-C., Kuo, C-F., Cheng, M-H., Wan, S-W., Lin, C-F., Chang, C-P., Lin, Y-S., Wu, J-J., Huang, C-C. & Chen, C-L., 2019, 於 : Frontiers in Immunology. 10, p. 2147 1 p.

研究成果: 雜誌貢獻文章

Hirsutanol A attenuates lipopolysaccharide-mediated matrix metalloproteinase 9 expression and cytokines production and improves endotoxemia-induced acute sickness behavior and acute lung injury

Jan, J. S., Yang, C. H., Wang, M. H., Lin, F. L., Yen, J. L., Hsieh, I., Khotimchenko, M., Lee, T. H. & Hsiao, G., 六月 17 2019, 於 : Marine Drugs. 17, 6, 360.

研究成果: 雜誌貢獻文章

開啟存取
Illness Behavior
Endotoxemia
Acute Lung Injury
Matrix Metalloproteinase 9
Lipopolysaccharides

Identification of two independent SUMO-interacting motifs in Fas-associated factor 1 (FAF1): Implications for mineralocorticoid receptor (MR)-mediated transcriptional regulation

Wang, C. H., Hung, P. W., Chiang, C. W., Lombès, M., Chen, C. H., Lee, K. H., Lo, Y. C., Wu, M. H., Chang, W. C. & Lin, D. Y., 八月 1 2019, 於 : Biochimica et Biophysica Acta - Molecular Cell Research. 1866, 8, p. 1282-1297 16 p.

研究成果: 雜誌貢獻文章

Mineralocorticoid Receptors
Ubiquitin
Catenins
Aldosterone
Transcriptional Activation
開啟存取
Aquaporin 1
Caveolin 1
Brain Edema
Gold
Nanoparticles
2 引文 (Scopus)
Regulatory T-Lymphocytes
Adenoviridae
Dendritic Cells
Asthma
Ovalbumin

Melatonin promotes neuroblastoma cell differentiation by activating hyaluronan synthase 3-induced mitophagy

Lee, W. J., Chen, L. C., Lin, J. H., Cheng, T. C., Kuo, C. C., Wu, C. H., Chang, H. W., Tu, S. H. & Ho, Y. S., 一月 1 2019, 於 : Cancer Medicine. 8, 10, p. 4821-4835 15 p.

研究成果: 雜誌貢獻文章

開啟存取
Mitochondrial Degradation
Melatonin
Neuroblastoma
Cell Differentiation
Spontaneous Remission
2 引文 (Scopus)

Membrane protein-regulated networks across human cancers

Lin, C. Y., Lee, C. H., Chuang, Y. H., Lee, J. Y., Chiu, Y. Y., Wu Lee, Y. H., Jong, Y. J., Hwang, J. K., Huang, S. H., Chen, L. C., Wu, C. H., Tu, S. H., Ho, Y. S. & Yang, J. M., 十二月 1 2019, 於 : Nature Communications. 10, 1, 3131.

研究成果: 雜誌貢獻文章

開啟存取
Membrane Proteins
cancer
membranes
proteins
Neoplasms
1 引文 (Scopus)
開啟存取
Anisakis
Perciformes
Zoonoses
Taiwan
Ascaris
1 引文 (Scopus)
Ingrown Nails
Braces
Nails
Pediatrics
Therapeutics

New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury

Lu, W-J., Lin, K-H., Tseng, M-F., Yuan, K-C., Huang, H-C., Sheu, J-R. & Chen, R-J., 三月 1 2019, 於 : Journal of Cellular and Molecular Medicine. 23, 3, p. 1723-1734 12 p.

研究成果: 雜誌貢獻文章

Hemorrhagic Shock
Liver
Wounds and Injuries
Resuscitation
Therapeutics

Orexin-A Levels in Relation to the Risk of Metabolic Syndrome in Patients with Schizophrenia Taking Antipsychotics

Chen, P-Y., Chen, C-H., Chang, C-K., Kao, C-F., Lu, M-L., Lin, S-K., Huang, M-C., Hwang, L-L. & Mondelli, V., 一月 1 2019, 於 : International Journal of Neuropsychopharmacology. 22, 1, p. 28-36 9 p.

研究成果: 雜誌貢獻文章

Antipsychotic Agents
Schizophrenia
Clozapine
Metabolome
Odds Ratio
4 引文 (Scopus)

Post-injury neuroprotective effects of the thalidomide analog 3,6′-dithiothalidomide on traumatic brain injury

Batsaikhan, B., Wang, J. Y., Scerba, M. T., Tweedie, D., Greig, N. H., Miller, J. P., Hoffer, B. J., Lin, C. T. & Wang, J. Y., 二月 1 2019, 於 : International Journal of Molecular Sciences. 20, 3, 502.

研究成果: 雜誌貢獻文章

開啟存取
brain damage
Thalidomide
Neuroprotective Agents
Brain
analogs

Promyelocytic leukemia zinc finger is involved in the formation of deep layer cortical neurons

Lin, H. C., Ching, Y. H., Huang, C. C., Pao, P. C., Lee, Y. H., Chang, W. C., Kao, T. J. & Lee, Y. C., 四月 26 2019, 於 : Journal of Biomedical Science. 26, 1, 30.

研究成果: 雜誌貢獻文章

開啟存取
Zinc Fingers
Neurons
Zinc
Leukemia
Brain
Brain Concussion
Psychometrics
Longitudinal Studies
Sleep
Anxiety
1 引文 (Scopus)

RAB27B-activated secretion of stem-like tumor exosomes delivers the biomarker microRNA-146a-5p, which promotes tumorigenesis and associates with an immunosuppressive tumor microenvironment in colorectal cancer

Cheng, W. C., Liao, T. T., Lin, C. C., Yuan, L. T. E., Lan, H. Y., Lin, H. H., Teng, H. W., Chang, H. C., Lin, C. H., Yang, C. Y., Huang, S. C., Jiang, J. K., Yang, S. H., Yang, M. H. & Hwang, W. L., 一月 1 2019, 於 : International Journal of Cancer.

研究成果: 雜誌貢獻文章

Exosomes
Tumor Microenvironment
Immunosuppressive Agents
MicroRNAs
Neoplastic Stem Cells

Sp1 in Astrocyte Is Important for Neurite Outgrowth and Synaptogenesis

Hung, C. Y., Hsu, T. I., Chuang, J. Y., Su, T. P., Chang, W. C. & Hung, J. J., 一月 1 2019, 於 : Molecular Neurobiology.

研究成果: 雜誌貢獻文章

Astrocytes
Synapses
Hippocampus
Neurons
Toll-Like Receptor 2
1 引文 (Scopus)
Lipolysis
Cyclic AMP-Dependent Protein Kinases
Adipocytes
Protein Kinases
Lipase

The fungus-derived retinoprotectant theissenolactone C improves glaucoma-like injury mediated by MMP-9 inhibition

Lin, F. L., Cheng, Y. W., Yu, M., Ho, J. D., Kuo, Y. C., Chiou, G. C. Y., Chang, H. M., Lee, T. H. & Hsiao, G., 三月 15 2019, 於 : Phytomedicine. 56, p. 207-214 8 p.

研究成果: 雜誌貢獻文章

Matrix Metalloproteinase 9
Glaucoma
Reperfusion Injury
Interleukin-1
Chemokine CCL2

The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock

Myung, J., Wu, M. Y., Lee, C. Y., Rahim, A. R., Truong, V. H., Wu, D., Piggins, H. D. & Wu, M. S., 六月 1 2019, 於 : International Journal of Molecular Sciences. 20, 11, 2765.

研究成果: 雜誌貢獻文章

開啟存取
Circadian Clocks
kidneys
clocks
Clocks
Kidney

The role of ubiquitin-specific peptidases in cancer progression

Young, M. J., Hsu, K. C., Lin, T. E., Chang, W. C. & Hung, J. J., 五月 27 2019, 於 : Journal of Biomedical Science. 26, 1, 42.

研究成果: 雜誌貢獻回顧型文獻

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Ubiquitin
Peptide Hydrolases
Ubiquitination
Neoplasms
Proteins

The α9 nicotinic acetylcholine receptor mediates nicotine-induced pd-l1 expression and regulates melanoma cell proliferation and migration

Nguyen, H. D., Liao, Y. C., Ho, Y. S., Chen, L. C., Chang, H. W., Cheng, T. C., Liu, D., Lee, W. R., Shen, S. C., Wu, C. H. & Tu, S. H., 十二月 2019, 於 : Cancers. 11, 12, 1991.

研究成果: 雜誌貢獻文章

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3 引文 (Scopus)

Triple-negative breast cancer: Current understanding and future therapeutic breakthrough targeting cancer stemness

Lee, K. L., Kuo, Y. C., Ho, Y. S. & Huang, Y. H., 九月 2019, 於 : Cancers. 11, 9, 1334.

研究成果: 雜誌貢獻回顧型文獻

開啟存取
Triple Negative Breast Neoplasms
Neoplastic Stem Cells
Neoplasms
Therapeutics
Breast Neoplasms

Weak coupling between intracellular feedback loops explains dissociation of clock gene dynamics

Schmal, C., Ono, D., Myung, J., Pett, J. P., Honma, S., Honma, K. I., Herzel, H. & Tokuda, I. T., 九月 12 2019, 於 : PLoS Computational Biology. 15, 9, p. e1007330 e1007330.

研究成果: 雜誌貢獻文章

開啟存取
circadian rhythm
Weak Coupling
Feedback Loop
gene expression
Clocks