臨床醫學研究所

  • No. 250 Wu-Xing Street

    11031 Taipei

研究成果 1988 2020

篩選
文章
2020

A multicenter, phase I/II trial of biweekly S-1, leucovorin, oxaliplatin and gemcitabine in metastatic pancreatic adenocarcinoma–TCOG T1211 study

Chiang, N. J., Tsai, K. K., Hsiao, C. F., Yang, S. H., Hsiao, H. H., Shen, W. C., Hsu, C., Lin, Y. L., Chen, J. S., Shan, Y. S. & Chen, L. T., 一月 2020, 於 : European Journal of Cancer. 124, p. 123-130 8 p.

研究成果: 雜誌貢獻文章

oxaliplatin
gemcitabine
Leucovorin
Adenocarcinoma
irinotecan
開啟存取
temozolomide
Glioblastoma
Histones
Interleukin-6
Up-Regulation

In vitro and in vivo evaluation of the neuroprotective activity of Uncaria hirsuta Haviland

Lin, C. M., Lin, Y. T., Lee, T. L., Imtiyaz, Z., Hou, W. C. & Lee, M. H., 一月 2020, 於 : Journal of Food and Drug Analysis. 28, 1, p. 147-158 12 p.

研究成果: 雜誌貢獻文章

開啟存取
Uncaria
neuroprotective effect
Inhibitory Concentration 50
inhibitory concentration 50
Oxidopamine

Optimal measuring timing of cystatin C for early detection of contrast-induced acute kidney injury: A systematic review and meta-analysis

Chen, C. T., Chang, L. Y., Chuang, C. W., Wang, S. C., Kao, M. C., Tzeng, I. S., Kuo, K. L., Wu, C. C., Tsai, P. S. & Huang, C. J., 一月 2020, 於 : Toxicology Letters. 318, p. 65-73 9 p.

研究成果: 雜誌貢獻文章

Cystatin C
Acute Kidney Injury
Meta-Analysis
Contrast Media
Peripheral Catheterization
2019

A bioinspired hyperthermic macrophage-based polypyrrole-polyethylenimine (Ppy-PEI) nanocomplex carrier to prevent and disrupt thrombotic fibrin clots

Burnouf, T., Chen, C. H., Tan, S. J., Tseng, C. L., Lu, K. Y., Chang, L. H., Nyambat, B., Huang, S. C., Jheng, P. R., Aditya, R. N., Mi, F. L. & Chuang, E. Y., 九月 15 2019, 於 : Acta Biomaterialia. 96, p. 468-479 12 p.

研究成果: 雜誌貢獻文章

Polyethyleneimine
Macrophages
Polypyrroles
Fibrin
Radiation
3 引文 (Scopus)

Adenylate kinase 4 modulates oxidative stress and stabilizes HIF-1α to drive lung adenocarcinoma metastasis

Jan, Y. H., Lai, T. C., Yang, C. J., Lin, Y. F., Huang, M. S. & Hsiao, M., 一月 29 2019, 於 : Journal of Hematology and Oncology. 12, 1, 12.

研究成果: 雜誌貢獻文章

Adenylate Kinase
Oxidative Stress
Neoplasm Metastasis
Lung Neoplasms
Epithelial-Mesenchymal Transition
Mitochondrial DNA
Embryonic Structures
Biomarkers
Blastocyst
Blastomeres

Adverse stroke outcomes among patients with bipolar disorder

Chen, P. H., Kao, Y. W., Shia, B. C., Lin, H. C. & Kang, J. H., 三月 1 2019, 於 : PLoS One. 14, 3, p. e0213072 e0213072.

研究成果: 雜誌貢獻文章

開啟存取
Bipolar Disorder
stroke
Stroke
Length of Stay
Hospital Mortality
1 引文 (Scopus)

Alteration of mesenchymal stem cells polarity by laminar shear stimulation promoting β-catenin nuclear localization

Chen, W-T., Hsu, W-T., Yen, M-H., Changou, C. A., Han, C-L., Chen, Y-J., Cheng, J-Y., Chang, T-H., Lee, O. K-S. & Ho, J. H-C., 一月 1 2019, 於 : Biomaterials. 190-191, p. 1-10 10 p.

研究成果: 雜誌貢獻文章

Catenins
Cell Polarity
Stem cells
Mesenchymal Stromal Cells
Shear stress
開啟存取
Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Radiation Tolerance
Autophagy
Proteins

Angiotensin-converting enzyme inhibitors or angiotensin receptor blocker monotherapy retard deterioration of renal function in Taiwanese chronic kidney disease population

Zheng, C. M., Wang, J. Y., Chen, T. T., Wu, Y. C., Wu, Y. L., Lin, H. T., Chiu, S. P., Chang, T. J., Zheng, J. Q., Chu, N. F., Lin, Y. M., Su, S. L., Lu, K. C., Chen, J. S., Sung, F. C., Lee, C. T., Yang, Y., Hwang, S. J., Wang, M. C., Hsu, Y. H. 及其他4, Chiou, H. Y., Kao, S., Wu, M. Y. & Lin, Y. F., 十二月 1 2019, 於 : Scientific Reports. 9, 1, 2694.

研究成果: 雜誌貢獻文章

開啟存取
Angiotensin Receptor Antagonists
Chronic Renal Insufficiency
Angiotensin-Converting Enzyme Inhibitors
Angiotensins
Kidney
2 引文 (Scopus)

An Open-Label, Multicenter, Phase I, Dose Escalation Study with Phase II Expansion Cohort to Determine the Safety, Pharmacokinetics, and Preliminary Antitumor Activity of Intravenous TKM-080301 in Subjects with Advanced Hepatocellular Carcinoma

El Dika, I., Lim, H. Y., Yong, W. P., Lin, C. C., Yoon, J. H., Modiano, M., Freilich, B., Choi, H. J., Chao, T. Y., Kelley, R. K., Brown, J., Knox, J., Ryoo, B. Y., Yau, T. & Abou-Alfa, G. K., 一月 1 2019, (接受/付印) 於 : Oncologist.

研究成果: 雜誌貢獻文章

開啟存取
Maximum Tolerated Dose
Hepatocellular Carcinoma
Pharmacokinetics
Safety
Small Interfering RNA
Castration
Autophagy
Prostatic Neoplasms
Cell Death
Osteogenesis
Povidone-Iodine
Local Anti-Infective Agents
Chlorhexidine
Meta-Analysis
Randomized Controlled Trials
1 引文 (Scopus)

Antrocin, a bioactive component from Antrodia cinnamomea, suppresses breast carcinogenesis and stemness via downregulation of β-catenin/Notch1/Akt signaling

Chen, J. H., T.H Wu, A., T.W Tzeng, D., Huang, C. C., Tzeng, Y. M. & Chao, T. Y., 一月 1 2019, 於 : Phytomedicine. 52, p. 70-78 9 p.

研究成果: 雜誌貢獻文章

Antrodia
Catenins
Carcinogenesis
Breast
Down-Regulation
5 引文 (Scopus)

ASPM promotes prostate cancer stemness and progression by augmenting Wnt−Dvl-3−β-catenin signaling

Pai, V. C., Hsu, C. C., Chan, T. S., Liao, W. Y., Chuu, C. P., Chen, W-Y., Li, C. R., Lin, C. Y., Huang, S. P., Chen, L. T. & Tsai, K. K., 二月 21 2019, 於 : Oncogene. 38, 8, p. 1340-1353 14 p.

研究成果: 雜誌貢獻文章

Catenins
Microcephaly
Prostatic Neoplasms
Neoplastic Stem Cells
Neoplasms
開啟存取
Acid Sensing Ion Channels
Brain Concussion
Dizziness
Alleles
Genes

Association of EGFR mutations and HMGB1 genetic polymorphisms in lung adenocarcinoma patients

Wu, Y. L., Chien, M. H., Chou, Y. E., Chang, J. H., Liu, T. C., Tsao, T. C. Y., Chou, M. C. & Yang, S. F., 一月 1 2019, 於 : Journal of Cancer. 10, 13, p. 2907-2914 8 p.

研究成果: 雜誌貢獻文章

開啟存取
HMGB1 Protein
Genetic Polymorphisms
Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Mutation

Association of endothelin genetic variants and hospitalized infection complications in end-stage renal disease (ESRD) patients

Kao, C. C., Cheng, S. Y., Wang, Y. J., Chien, S. C., Hsu, Y. W., Wu, M. Y., Lu, H. F., Nam, S., Sun, T., Wu, M. S. & Chang, W. C., 六月 5 2019, 於 : BMC Nephrology. 20, 1, p. 203 203.

研究成果: 雜誌貢獻文章

開啟存取
Endothelins
Chronic Kidney Failure
Bacteremia
Infection
Single Nucleotide Polymorphism
1 引文 (Scopus)
Hashimoto Disease
Osteopontin
Lymphocytes
Graves Disease
Thyroid Diseases
1 引文 (Scopus)
開啟存取
Penfluridol
Unfolded Protein Response
Lung Neoplasms
Cell Death
Adenosine Triphosphate
4 引文 (Scopus)
bromelains
Bromelains
autophagy
Autophagy
colorectal neoplasms
Triple Negative Breast Neoplasms
Catenins
Neoplastic Stem Cells
Down-Regulation
Phenotype

Chemotherapy agents induce tartrate-resistant acid phosphatase 5a contributing to the symptom distress in lung cancer patients

Chou, H. L., Chao, T. Y., Chen, T. C., Chu, C. M., Hsieh, C. H., Lin, L. I. & Yao, C. T., 三月 5 2019, 於 : European Journal of Pharmacology. p. 38-48 11 p.

研究成果: 雜誌貢獻文章

Lung Neoplasms
Drug Therapy
Monocytes
Macrophages
gemcitabine
1 引文 (Scopus)
開啟存取
sphingosine
Biomarkers
pneumonia
biomarkers
Pneumonia
1 引文 (Scopus)

Cluster of differentiation 14 and toll-like receptor 4 are involved in the anti-inflammatory effects of tyrosol

Chang, C. Y., Huang, I. T., Shih, H. J., Chang, Y. Y., Kao, M. C., Shih, P. C. & Huang, C. J., 二月 1 2019, 於 : Journal of Functional Foods. 53, p. 93-104 12 p.

研究成果: 雜誌貢獻文章

Toll-Like Receptor 4
anti-inflammatory activity
lipopolysaccharides
Lipopolysaccharides
Anti-Inflammatory Agents
Hemophilia A
Mutation
DNA
Exons
Genes
1 引文 (Scopus)
Bioinformatics
Computational Biology
colorectal neoplasms
MicroRNAs
microRNA

Diabetic retinopathy as a risk factor for chronic kidney disease progression: A multicenter case–control study in Taiwan

Lin, H. T., Zheng, C. M., Wu, Y. C., Chang, Y. H., Chen, J. T., Liang, C. M., Chang, T. J., Zheng, J. Q., Tai, M. C. & Lin, Y. F., 三月 1 2019, 於 : Nutrients. 11, 3, 509.

研究成果: 雜誌貢獻文章

開啟存取
diabetic retinopathy
Diabetic Retinopathy
kidney diseases
Taiwan
Chronic Renal Insufficiency

Differences between COPD patients and their families regarding willingness toward life-sustaining treatments

Chen, T. R., Hu, W. Y., Chiu, T. Y. & Kuo, H. P., 一月 2019, (接受/付印) 於 : Journal of the Formosan Medical Association. 118, 1P3, p. 414-419

研究成果: 雜誌貢獻文章

Chronic Obstructive Pulmonary Disease
Therapeutics
Medical Futility
Persistent Vegetative State
Noninvasive Ventilation
3 引文 (Scopus)

DNA primase polypeptide 1 (PRIM1) involves in estrogen-induced breast cancer formation through activation of the G2/M cell cycle checkpoint

Lee, W-H., Chen, L-C., Lee, C-J., Huang, C-C., Ho, Y-S., Yang, P-S., Ho, C-T., Chang, H-L., Lin, I-H., Chang, H-W., Liu, Y-R., Wu, C-H. & Tu, S-H., 二月 1 2019, 於 : International Journal of Cancer. 144, 3, p. 615-630 16 p.

研究成果: 雜誌貢獻文章

DNA Primase
G2 Phase Cell Cycle Checkpoints
Estrogens
Breast Neoplasms
Peptides

Does long-term use of antidiabetic drugs changes cancer risk?

Liu, Y. C., Nguyen, P. A., Humayun, A., Chien, S. C., Yang, H. C., Asdary, R. N., Syed-Abdul, S., Hsu, M. H., Moldovan, M., Yen, Y., Li, Y. C., Jian, W. S. & Iqbal, U., 十月 1 2019, 於 : Medicine (United States). 98, 40, p. e17461 e17461.

研究成果: 雜誌貢獻文章

開啟存取
Hypoglycemic Agents
pioglitazone
Neoplasms
Odds Ratio
Confidence Intervals

Dysregulated iron metabolism-associated dietary pattern predicts an altered body composition and metabolic syndrome

Cempaka, A. R., Tseng, S. H., Yuan, K. C., Bai, C. H., Tinkov, A. A., Skalny, A. V. & Chang, J. S., 十一月 2019, 於 : Nutrients. 11, 11, 2733.

研究成果: 雜誌貢獻文章

開啟存取
metabolic syndrome
Body Composition
eating habits
body composition
Iron

Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease

Lau, C. I., Liu, M. N., Chang, K. C., Chang, A., Bai, C. H., Tseng, C. S., Walsh, V. & Wang, H. C., 一月 1 2019, (接受/付印) 於 : CNS Neuroscience and Therapeutics.

研究成果: 雜誌貢獻文章

開啟存取
Cognition
Parkinson Disease
Prefrontal Cortex
Short-Term Memory
Disruptive, Impulse Control, and Conduct Disorders
1 引文 (Scopus)
開啟存取
Bariatric Surgery
Glomerular Filtration Rate
Chronic Renal Insufficiency
Weight Loss
Propensity Score
開啟存取
Autoimmune Thyroiditis
Thyroglobulin
Melatonin
Thyroid Gland
Inbred C57BL Mouse
Meibomian Glands
Meta-Analysis
Randomized Controlled Trials
Hot Temperature
Eye Diseases
2 引文 (Scopus)
開啟存取
diabetes mellitus
Streptozocin
Medical problems
rats
Rats
2 引文 (Scopus)

Endotypes of severe allergic asthma patients who clinically benefit from anti-IgE therapy

Huang, Y. C., Weng, C. M., Lee, M. J., Lin, S. M., Wang, C. H. & Kuo, H-P., 一月 1 2019, 於 : Clinical and Experimental Allergy. 49, 1, p. 44-53 10 p.

研究成果: 雜誌貢獻文章

Asthma
Therapeutics
Cytokines
Inflammation
anti-IgE antibodies
開啟存取
Uropathogenic Escherichia coli
Escherichia coli Infections
Urinary Tract Infections
Diabetes Mellitus
Cystitis

Genetic variants in the circadian rhythm pathway as indicators of prostate cancer progression

Yu, C. C., Chen, L. C., Chiou, C. Y., Chang, Y. J., Lin, V. C., Huang, C. Y., Lin, I. L., Chang, T. Y., Lu, T. L., Lee, C. H., Huang, S. P. & Bao, B. Y., 四月 5 2019, 於 : Cancer Cell International. 19, 1, 87.

研究成果: 雜誌貢獻文章

開啟存取
Circadian Rhythm
Prostatic Neoplasms
Alleles
Computer Simulation
Disease-Free Survival
1 引文 (Scopus)

Geniposide ameliorated fluoxetine-suppressed neurite outgrowth in Neuro2a neuroblastoma cells

Chen, M. K., Peng, C. C., Maner, R. S., Zulkefli, N. D., Huang, S. M. & Hsieh, C. L., 六月 1 2019, 於 : Life Sciences. 226, p. 1-11 11 p.

研究成果: 雜誌貢獻文章

geniposide
Fluoxetine
Neuroblastoma
Neurites
Iridoids

Glucose-Regulated Protein 94 Modulates the Response of Osteosarcoma to Chemotherapy

Huang, C. Y., Wei, P. L., Wang, J. W., Makondi, P. T., Huang, M. T., Chen, H. A. & Chang, Y. J., 一月 1 2019, 於 : Disease Markers. 2019, 1 p.

研究成果: 雜誌貢獻文章

Chemotherapy
Osteosarcoma
gemcitabine
Drug Therapy
Epirubicin
開啟存取
Cell Cycle Proteins
Epithelial-Mesenchymal Transition
regulators
Prostatic Neoplasms
genes
Reducing Diet
Haptoglobins
Phenotype
Waist Circumference
Abdominal Obesity
2 引文 (Scopus)
Histone Deacetylases
Transcriptional Activation
Glycogen Synthase Kinase 3
Bone Morphogenetic Proteins
Catenins
Ventilator-Induced Lung Injury
Continuous Positive Airway Pressure
Lung Injury
Pneumonia
Respiration

Histone demethylase KDM4C stimulates the proliferation of prostate cancer cells via activation of AKT and c-Myc

Lin, C. Y., Wang, B. J., Chen, B. C., Tseng, J. C., Jiang, S. S., Tsai, K. K., Shen, Y. Y., Yuh, C. H., Sie, Z. L., Wang, W. C., Kung, H. J. & Chuu, C. P., 十一月 2019, 於 : Cancers. 11, 11, 1785.

研究成果: 雜誌貢獻文章

開啟存取
Histone Demethylases
Prostatic Neoplasms
Prostate
Androgen Receptors
Cell Proliferation