生物化學暨細胞分子生物學科

研究成果 1994 2020

2018
Pancreatic Ribonuclease
Calorimetry
Surface charge
Chromatography
Titration
27 引文 (Scopus)
Arginine
Chitosan
Nanoparticles
Pharmaceutical Preparations
Curcumin
4 引文 (Scopus)

Oral Nonviral Gene Delivery for Chronic Protein Replacement Therapy

Lin, P. Y., Chiu, Y. L., Huang, J. H., Chuang, E. Y., Mi, F. L., Lin, K. J., Juang, J. H., Sung, H. W. & Leong, K. W., 八月 1 2018, 於 : Advanced Science. 5, 8, 1701079.

研究成果: 雜誌貢獻文章

insulin
plasmids
Insulin
genes
therapy
3 引文 (Scopus)

PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model

Chiu, C. C., Lu, C. S., Weng, Y. H., Chen, Y. L., Huang, Y. Z., Chen, R. S., Cheng, Y. C., Huang, Y. C., Liu, Y. C., Lai, S. C., Lin, K. J., Lin, Y. W., Chen, Y. J., Chen, C. L., Yeh, T. H. & Wang, H. L., 一月 1 2018, (接受/付印) 於 : Molecular Neurobiology.

研究成果: 雜誌貢獻文章

Mitochondrial Degradation
Dopaminergic Neurons
Substantia Nigra
Mutation
Parkinson Disease
4 引文 (Scopus)

Plasmon-activated water effectively relieves hepatic oxidative damage resulting from chronic sleep deprivation

Chen, H-C., Cheng, C-Y., Chen, L-Y., Chang, C-C., Yang, C-P., Mai, F-D., Liao, W-C., Chang, H-M. & Liu, Y-C., 2018, 於 : RSC Advances. 8, 18, p. 9618-9626 9 p.

研究成果: 雜誌貢獻文章

Water
Liver
Protective Agents
Rats
Sleep
3 引文 (Scopus)

PMA inhibits endothelial cell migration through activating the PKC-δ/Syk/NF-κB-mediated up-regulation of Thy-1

Wen, H. C., Huo, Y. N., Chou, C. M. & Lee, W. S., 十二月 1 2018, 於 : Scientific Reports. 8, 1, 16247.

研究成果: 雜誌貢獻文章

Cell Movement
Acetates
Up-Regulation
Endothelial Cells
phorbol-12-myristate
2 引文 (Scopus)
Polypyrroles
Polymerization
Electrodes
Water
Deionized water
Endothelial cells
Human Umbilical Vein Endothelial Cells
Progesterone
Up-Regulation
Protein Binding
4 引文 (Scopus)

Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems

Lin, Y. J., Mi, F. L., Lin, P. Y., Miao, Y. B., Huang, T., Chen, K. H., Chen, C. T., Chang, Y. & Sung, H. W., 一月 1 2018, (接受/付印) 於 : Advanced Drug Delivery Reviews.

研究成果: 雜誌貢獻文章

Complementary Therapies
Cutaneous Administration
Insulin
Subcutaneous Injections
Quality of Life
1 引文 (Scopus)

Surface-Enhanced Raman Scattering-Active Substrate Prepared with New Plasmon-Activated Water

Yang, C. P., Fang, S. U., Yang, K. H., Chen, H. C., Tsai, H. Y., Mai, F. D. & Liu, Y. C., 一月 1 2018, 於 : ACS Omega. 3, 5, p. 4743-4751 9 p.

研究成果: 雜誌貢獻文章

Raman scattering
Deionized water
Water
Substrates
Hydrogen
4 引文 (Scopus)

Synthesis and evaluation of antibacterial and anti-oxidant activity of small molecular chitosan–fucoidan conjugate nanoparticles

Tsai, L. C., Tsai, M. L., Lu, K. Y. & Mi, F. L., 三月 1 2018, (接受/付印) 於 : Research on Chemical Intermediates. p. 1-17 17 p.

研究成果: 雜誌貢獻文章

Oxidants
Molecular weight
Nanoparticles
Chitosan
Scavenging
1 引文 (Scopus)

Therapeutics for inflammatory-related diseases based on plasmon-activated water: A review

Yang, C. P. & Liu, Y. C., 六月 1 2018, 於 : International Journal of Molecular Sciences. 19, 6, 1589.

研究成果: 雜誌貢獻回顧型文獻

Water
water
Therapeutics
Deionized water
Hydrogen
4 引文 (Scopus)
Acetylgalactosamine
Hyperoxia
NF-kappa B
Lung Injury
Threonine
2017
35 引文 (Scopus)

Active gellan gum/purple sweet potato composite films capable of monitoring pH variations

Wei, Y. C., Cheng, C. H., Ho, Y. C., Tsai, M. L. & Mi, F. L., 八月 1 2017, 於 : Food Hydrocolloids. 69, p. 491-502 12 p.

研究成果: 雜誌貢獻文章

Ipomoea batatas
gellan gum
Anthocyanins
Composite films
sweet potatoes
2 引文 (Scopus)
Colistin
Mass spectrometry
Mass Spectrometry
Blood
Prodrugs
20 引文 (Scopus)
Antrodia
Taiwanofungus camphoratus
Ubiquinone
Neoplastic Stem Cells
ubiquinones
27 引文 (Scopus)
Catalase
Nanocrystals
Cells
Cell death
Hydroxyl Radical

Correction: Inflammation promotes expression of stemness-related properties in hbv-related hepatocellular carcinoma (PLoS ONE (2016)11:2 (e0149897) DOI: 10.1371/journal.pone.0149897)

Chang, T. S., Chen, C. L., Wu, Y. C., Liu, J. J., Kuo, Y. C., Lee, K. F., Lin, S. Y., Lin, S. E., Tung, S. Y., Kuo, L. M., Tsai, Y. H. & Huang, Y. H., 一月 1 2017, 於 : PLoS One. 12, 1, e0171176.

研究成果: 雜誌貢獻評論/辯論

Organized Financing
hepatoma
funding
Hepatocellular Carcinoma
inflammation
Mitochondria
Alkaloids
Medicine
Apoptosis
Calcium
2 引文 (Scopus)
Glioma
Medicine
Down-Regulation
RNA
Apoptosis
Luteolin
uterine cervical neoplasms
luteolin
Quercetin
Flavonoids
3 引文 (Scopus)
Gold
Medicine
Nanoparticles
Water
Hydrogen bonds
37 引文 (Scopus)

Development of a new type of multifunctional fucoidan-based nanoparticles for anticancer drug delivery

Lu, K. Y., Li, R., Hsu, C. H., Lin, C. W., Chou, S. C., Tsai, M. L. & Mi, F. L., 六月 1 2017, 於 : Carbohydrate Polymers. 165, p. 410-420 11 p.

研究成果: 雜誌貢獻文章

Drug delivery
Nanoparticles
Cells
Chitosan
Protamines
5 引文 (Scopus)

Development of an LC-MS/MS method with protein G purification strategy for quantifying bevacizumab in human plasma

Chiu, H. H., Tsai, I. L., Lu, Y. S., Lin, C. H. & Kuo, C. H., 九月 29 2017, (接受/付印) 於 : Analytical and Bioanalytical Chemistry. p. 1-11 11 p.

研究成果: 雜誌貢獻文章

Plasma (human)
Purification
Monoclonal Antibodies
Pharmaceutical Preparations
Proteins
12 引文 (Scopus)

Development of genipin-crosslinked fucoidan/chitosan-N-arginine nanogels for preventing Helicobacter infection

Lin, Y. H., Lu, K. Y., Tseng, C. L., Wu, J. Y., Chen, C. H. & Mi, F. L., 六月 1 2017, 於 : Nanomedicine. 12, 12, p. 1491-1510 20 p.

研究成果: 雜誌貢獻文章

Arginine
Chitosan
Helicobacter Infections
Helicobacter pylori
drug
14 引文 (Scopus)

Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial-mesenchymal transition signaling

Lin, T. H., Hsu, W. H., Tsai, P. H., Huang, Y. T., Lin, C. W., Chen, K. C., Tsai, I. H., Kandaswami, C. C., Huang, C. J., Chang, G. D., Lee, M. T. & Cheng, C. H., 四月 1 2017, 於 : Food and Function. 8, 4, p. 1558-1568 11 p.

研究成果: 雜誌貢獻文章

Luteolin
uterine cervical neoplasms
Epithelial-Mesenchymal Transition
luteolin
Quercetin
30 引文 (Scopus)

Elevation of YAP promotes the epithelial-mesenchymal transition and tumor aggressiveness in colorectal cancer

Ling, H. H., Kuo, C. C., Lin, B. X., Huang, Y. H. & Lin, C. W., 一月 1 2017, 於 : Experimental Cell Research. 350, 1, p. 218-225 8 p.

研究成果: 雜誌貢獻文章

Epithelial-Mesenchymal Transition
Colorectal Neoplasms
Neoplasms
Proteins
Neoplasm Metastasis
7 引文 (Scopus)

Emi2 Is Essential for Mouse Spermatogenesis

Gopinathan, L., Szmyd, R., Low, D., Diril, M. K., Chang, H. Y., Coppola, V., Liu, K., Tessarollo, L., Guccione, E., van Pelt, A. M. M. & Kaldis, P., 七月 18 2017, 於 : Cell Reports. 20, 3, p. 697-708 12 p.

研究成果: 雜誌貢獻文章

Spermatocytes
Meiosis
Spermatogenesis
Knockout Mice
Proto-Oncogene Proteins c-mos
20 引文 (Scopus)

Fluorescent nanodiamonds enable quantitative tracking of human mesenchymal stem cells in miniature pigs

Su, L. J., Wu, M. S., Hui, Y. Y., Chang, B. M., Pan, L., Hsu, P. C., Chen, Y. T., Ho, H. N., Huang, Y. H., Ling, T. Y., Hsu, H. H. & Chang, H. C., 三月 30 2017, 於 : Scientific Reports. 7, 45607.

研究成果: 雜誌貢獻文章

Nanodiamonds
Mesenchymal Stromal Cells
Swine
Placenta
Stem Cells
20 引文 (Scopus)
Macrophages
Selenium
Fluorescence
Nanoparticles
Imaging techniques
4 引文 (Scopus)

Hispolon Suppresses LPS- or LTA-Induced iNOS/NO Production and Apoptosis in BV-2 Microglial Cells

Wu, M. S., Chien, C. C., Cheng, K. T., Subbaraju, G. V. & Chen, Y. C., 2017, (接受/付印) 於 : American Journal of Chinese Medicine. p. 1-18 18 p.

研究成果: 雜誌貢獻文章

Nitric Oxide Synthase Type II
Nitric Oxide Synthase
Lipopolysaccharides
Nitric Oxide
Apoptosis
9 引文 (Scopus)
Somatomedins
Glioblastoma
MicroRNAs
Cytokines
Messenger RNA
7 引文 (Scopus)

Impacts of Cross-Linkers on Biological Effects of Mesoporous Silica Nanoparticles

Chen, Y. P., Wu, S. H., Chen, I. C. & Chen, C. T., 三月 22 2017, 於 : ACS Applied Materials and Interfaces. 9, 11, p. 10254-10265 12 p.

研究成果: 雜誌貢獻文章

Silicon Dioxide
Silica
Nanoparticles
Esters
Blood
1 引文 (Scopus)

Intraductal injection as an effective drug delivery route in the management of salivary gland diseases

Su, C. H., Lee, K. S., Tseng, T. M., Tseng, H., Ding, Y. F., Koch, M. & Hung, S. H., 一月 1 2017, 於 : European Archives of Oto-Rhino-Laryngology. 274, 1, p. 399-404 6 p.

研究成果: 雜誌貢獻文章

Salivary Gland Diseases
Injections
Submandibular Gland
Coloring Agents
Pharmaceutical Preparations
2 引文 (Scopus)

IRF9-Stat2 Fusion Protein as an Innate Immune Inducer to Activate Mx and Interferon-Stimulated Gene Expression in Zebrafish Larvae

Huang, C. J., Chou, C. M., Lien, H. W., Chu, C. Y., Ho, J. Y., Wu, Y. & Cheng, C. H., 五月 12 2017, (接受/付印) 於 : Marine Biotechnology. p. 1-10 10 p.

研究成果: 雜誌貢獻文章

Zebrafish
interferons
Danio rerio
Interferons
gene expression
Acid Phosphatase
Colorectal Neoplasms
Drug Therapy
Survival
Adjuvant Chemotherapy
19 引文 (Scopus)
Melatonin
Cognition
Energy Metabolism
Antioxidants
Oxidative Stress
14 引文 (Scopus)

microRNA let-7g suppresses PDGF-induced conversion of vascular smooth muscle cell into the synthetic phenotype

Wang, T. M., Chen, K. C., Hsu, P. Y., Lin, H. F., Wang, Y. S., Chen, C. Y., Liao, Y. C. & Juo, S. H. H., 2017, (接受/付印) 於 : Journal of Cellular and Molecular Medicine.

研究成果: 雜誌貢獻文章

Platelet-Derived Growth Factor
MicroRNAs
Vascular Smooth Muscle
Smooth Muscle Myocytes
MAP Kinase Kinase Kinase 1
14 引文 (Scopus)

Panobinostat sensitizes KRAS-mutant non-small-cell lung cancer to gefitinib by targeting TAZ

Lee, W. Y., Chen, P. C., Wu, W. S., Wu, H. C., Lan, C. H., Huang, Y. H., Cheng, C. H., Chen, K. C. & Lin, C. W., 2017, (接受/付印) 於 : International Journal of Cancer.

研究成果: 雜誌貢獻文章

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Histone Deacetylase Inhibitors
gefitinib
panobinostat
4 引文 (Scopus)

Podocalyxin-like protein 1 regulates TAZ signaling and stemness properties in colon cancer

Lee, W. Y., Kuo, C. C., Lin, B. X., Cheng, C. H., Chen, K. C. & Lin, C. W., 十月 1 2017, 於 : International Journal of Molecular Sciences. 18, 10, 2047.

研究成果: 雜誌貢獻文章

Colonic Neoplasms
cancer
proteins
Proteins
Neoplasms
9 引文 (Scopus)

Poly-Methyl Methacrylate/Polyvinyl Alcohol Copolymer Agents Applied on Diabetic Wound Dressing

Hsieh, H. T., Chang, H. M., Lin, W. J., Hsu, Y. T. & Mai, F. D., 十二月 1 2017, 於 : Scientific Reports. 7, 1, 9531.

研究成果: 雜誌貢獻文章

Polyvinyl alcohols
Polymethyl methacrylates
Hydrogels
Particles (particulate matter)
Copolymers
2 引文 (Scopus)

Rapid quantification of glutaminase 2 (GLS2)-related metabolites by HILIC-MS/MS

Chen, G. Y., Chao, H. C., Liao, H. W., Tsai, I. L. & Kuo, C. H., 十二月 15 2017, 於 : Analytical Biochemistry. 539, p. 39-44 6 p.

研究成果: 雜誌貢獻文章

Glutaminase
Metabolites
Glutamine
Glutathione
Glutamic Acid

Reply to letter “Therapeutic ductal injection in chronic sialadenitis is established”

Su, C. H., Lee, K. S., Tseng, T. M., Tseng, H., Ding, Y. F., Koch, M. & Hung, S. H., 一月 1 2017, 於 : European Archives of Oto-Rhino-Laryngology. 274, 1, p. 591-592 2 p.

研究成果: 雜誌貢獻快報

Sialadenitis
Injections
Therapeutics
12 引文 (Scopus)

Safety and efficacy of self-assembling bubble carriers stabilized with sodium dodecyl sulfate for oral delivery of therapeutic proteins

Lin, P. Y., Chuang, E-T., Chiu, Y. H., Chen, H. L., Lin, K. J., Juang, J. H., Chiang, C. H., Mi, F-L. & Sung, H. W., 八月 10 2017, 於 : Journal of Controlled Release. 259, p. 168-175

研究成果: 雜誌貢獻文章

Sodium Dodecyl Sulfate
Safety
Proteins
Insulin
Sodium Bicarbonate
10 引文 (Scopus)
Blood Proteins
Cells
Polypyrroles
Proteins
Plasmas
11 引文 (Scopus)

Sensitive screening of abused drugs in dried blood samples using ultra-high-performance liquid chromatography-ion booster-quadrupole time-of-flight mass spectrometry

Chepyala, D., Tsai, I. L., Liao, H. W., Chen, G. Y., Chao, H. C. & Kuo, C. H., 三月 31 2017, 於 : Journal of Chromatography A. 1491, p. 57-66 10 p.

研究成果: 雜誌貢獻文章

Preclinical Drug Evaluations
High performance liquid chromatography
Mass spectrometry
Mass Spectrometry
Screening
6 引文 (Scopus)

SEPT12 phosphorylation results in loss of the septin ring/sperm annulus, defective sperm motility and poor male fertility

Shen, Y. R., Wang, H. Y., Kuo, Y. C., Shih, S. C., Hsu, C. H., Chen, Y. R., Wu, S. R., Wang, C. Y. & Kuo, P. L., 三月 1 2017, 於 : PLoS Genetics. 13, 3, e1006631.

研究成果: 雜誌貢獻文章

開啟存取
Septins
Sperm Motility
male fertility
motility
sperm motility
5 引文 (Scopus)

Synthetic fluororutaecarpine inhibits inflammatory stimuli and activates endothelial transient receptor potential vanilloid-type 1

Lee, C-M., Gu, J. A., Rau, T. G., Wang, C., Yen, C. H., Huang, S. H., Lin, F. Y., Lin, C. M. & Huang, S. T., 四月 1 2017, 於 : Molecules. 22, 4, 656.

研究成果: 雜誌貢獻文章

vasodilation
macrophages
Macrophages
nitric oxide
Cytotoxicity
15 引文 (Scopus)
Photosensitizing Agents
Protamines
Breast Neoplasms
Temperature
Enzymes
10 引文 (Scopus)

The CHAC1-inhibited Notch3 pathway is involved in temozolomide-induced glioma cytotoxicity

Chen, P. H., Shen, W. L., Shih, C-M., Ho, K. H., Cheng, C-H., Lin, C-W., Lee, C-C., Liu, A. J. & Chen, K-C., 四月 1 2017, 於 : Neuropharmacology. 116, p. 300-314 15 p.

研究成果: 雜誌貢獻文章

temozolomide
Glioma
Glioblastoma
Poly(ADP-ribose) Polymerases
Transcriptome