Abstract

Background:While an association between zolpidem use and fracture and road accident was previously proposed, this study aimed to further explore the frequency and risk of a wide spectrum of injuries in subjects prescribed with zolpidem in Taiwan.Methods:We identified 77,036 subjects who received Zolpidem treatment between 2005 and 2007. We randomly selected 77,036 comparison subjects who were frequency-matched based-on their demographic profiles. We individually tracked each subject for a 90-day period to identify those who subsequently suffered an injury. Cox proportional hazards regressions were performed to calculate the hazard ratio of injury between the two groups.Results:The incidence rate of injury during the 90-day follow-up period for the total subjects was 18.11 (95% CI = 17.69-18.54) per 100 person-years; this was 24.35 (95% CI = 23.66-25.05) and 11.86 (95% CI = 11.39-12.36) for the study and comparison cohort, respectively. After adjusting for demographic variables, the hazard ratio (HR) of injury during the 90-day follow-up period for study subjects was 1.83 (95% CI = 1.73-1.94) that of comparison subjects. Additionally, compared to comparison subjects, the adjusted HR of injury during the 90-day follow-up period for study subjects who were prescribed Zolpidem for >30 days was as high as 2.17 (95% CI = 2.05-2.32). The adjusted HR of injury to blood vessels for study subjects was particularly high when compared to comparison subjects (HR = 6.34; 95% CI = 1.37-29.38).Conclusions:We found that patients prescribed with Zolpidem were at a higher risk for a wide range of injuries.

Original languageEnglish
Article numbere67459
JournalPLoS One
Volume8
Issue number6
DOIs
Publication statusPublished - Jun 27 2013

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Hazards
demographic statistics
Wounds and Injuries
accidents
blood vessels
Population
roads
Taiwan
incidence
Highway accidents
Blood vessels
Demography
zolpidem
methodology
Accidents
Blood Vessels
Cohort Studies
Incidence

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Zolpidem Use and the Risk of Injury : A Population-Based Follow-Up Study. / Chung, Shiu Dong; Lin, Ching Chun; Wang, Li Hsuan; Lin, Herng Ching; Kang, Jiunn Horng.

In: PLoS One, Vol. 8, No. 6, e67459, 27.06.2013.

Research output: Contribution to journalArticle

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abstract = "Background:While an association between zolpidem use and fracture and road accident was previously proposed, this study aimed to further explore the frequency and risk of a wide spectrum of injuries in subjects prescribed with zolpidem in Taiwan.Methods:We identified 77,036 subjects who received Zolpidem treatment between 2005 and 2007. We randomly selected 77,036 comparison subjects who were frequency-matched based-on their demographic profiles. We individually tracked each subject for a 90-day period to identify those who subsequently suffered an injury. Cox proportional hazards regressions were performed to calculate the hazard ratio of injury between the two groups.Results:The incidence rate of injury during the 90-day follow-up period for the total subjects was 18.11 (95{\%} CI = 17.69-18.54) per 100 person-years; this was 24.35 (95{\%} CI = 23.66-25.05) and 11.86 (95{\%} CI = 11.39-12.36) for the study and comparison cohort, respectively. After adjusting for demographic variables, the hazard ratio (HR) of injury during the 90-day follow-up period for study subjects was 1.83 (95{\%} CI = 1.73-1.94) that of comparison subjects. Additionally, compared to comparison subjects, the adjusted HR of injury during the 90-day follow-up period for study subjects who were prescribed Zolpidem for >30 days was as high as 2.17 (95{\%} CI = 2.05-2.32). The adjusted HR of injury to blood vessels for study subjects was particularly high when compared to comparison subjects (HR = 6.34; 95{\%} CI = 1.37-29.38).Conclusions:We found that patients prescribed with Zolpidem were at a higher risk for a wide range of injuries.",
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AU - Kang, Jiunn Horng

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