一口好牙 : 0-99歲的保健牙典

Translated title of the contribution: Yi kou hao ya : 0-99 sui de bao jian ya dian

Research output: Book/ReportBook

Abstract

Genes involved in the inflammation pathway have been associated with cancer risk. Genetic variants in the interleukin-6 (IL6) and prostaglandin-endoperoxide
synthase-2 (PTGS2, encoding for the COX-2 enzyme) genes, in particular, have been related to several cancer types, including breast and prostate cancers. We
conducted a study within the Breast and Prostate Cancer Cohort Consortium(BPC3) to examine the association between IL6 and PTGS2 polymorphisms and breast and prostate cancer risk. Twenty-seven polymorphisms, selected by pairwise tagging, were genotyped on 6,292 breast cancer cases and 8,135 matched controls and 8,008 prostate cancer cases and 8,604 matched controls. The
large sample sizes and comprehensive SNP tagging in this
study gave us excellent power to detect modest effects
for common variants. After adjustment for multiple
testing, none of the associations examined remained
statistically significant at P = 0.01. In analyses not
adjusted for multiple testing, one IL6 polymorphism
(rs6949149) was marginally associated with breast cancer
risk (TT vs. GG, OR: 1.32; 99% CI: 1.00-1.74,
P(trend)=0.003) and two were marginally associated with
prostate cancer risk (rs6969502-AA versus rs6969502-GG,
OR: 0.87, 99% CI: 0.75-1.02; P(trend) = 0.002 and
rs7805828-AA vs. rs7805828-GG, OR: 1.11, 99% CI: 0.99-
1.26; P(trend) = 0.007). An increase in breast cancer
risk was observed for the PTGS2 polymorphism rs7550380
(TT vs. GG, OR: 1.38, 99% CI: 1.04-1.83). No association
was observed between PTGS2 polymorphisms and prostate
cancer risk. In conclusion, common genetic variation in
these two genes might play at best a limited role in
breast and prostate cancers.
Original languageTraditional Chinese
Publisher臺視文化
Publication statusPublished - 2004

Fingerprint

Prostatic Neoplasms
Cyclooxygenase 2
Breast Neoplasms
Interleukin-6
Breast
Genes
Sample Size
Prostaglandins
Single Nucleotide Polymorphism
Neoplasms
Inflammation
Enzymes

Cite this

一口好牙 : 0-99歲的保健牙典. / Cheng, Hsin-Chung.

臺視文化, 2004.

Research output: Book/ReportBook

@book{6777bd4676394a38873a75df5ecb91d0,
title = "一口好牙 : 0-99歲的保健牙典",
abstract = "Genes involved in the inflammation pathway have been associated with cancer risk. Genetic variants in the interleukin-6 (IL6) and prostaglandin-endoperoxidesynthase-2 (PTGS2, encoding for the COX-2 enzyme) genes, in particular, have been related to several cancer types, including breast and prostate cancers. Weconducted a study within the Breast and Prostate Cancer Cohort Consortium(BPC3) to examine the association between IL6 and PTGS2 polymorphisms and breast and prostate cancer risk. Twenty-seven polymorphisms, selected by pairwise tagging, were genotyped on 6,292 breast cancer cases and 8,135 matched controls and 8,008 prostate cancer cases and 8,604 matched controls. Thelarge sample sizes and comprehensive SNP tagging in thisstudy gave us excellent power to detect modest effectsfor common variants. After adjustment for multipletesting, none of the associations examined remainedstatistically significant at P = 0.01. In analyses notadjusted for multiple testing, one IL6 polymorphism(rs6949149) was marginally associated with breast cancerrisk (TT vs. GG, OR: 1.32; 99{\%} CI: 1.00-1.74,P(trend)=0.003) and two were marginally associated withprostate cancer risk (rs6969502-AA versus rs6969502-GG,OR: 0.87, 99{\%} CI: 0.75-1.02; P(trend) = 0.002 andrs7805828-AA vs. rs7805828-GG, OR: 1.11, 99{\%} CI: 0.99-1.26; P(trend) = 0.007). An increase in breast cancerrisk was observed for the PTGS2 polymorphism rs7550380(TT vs. GG, OR: 1.38, 99{\%} CI: 1.04-1.83). No associationwas observed between PTGS2 polymorphisms and prostatecancer risk. In conclusion, common genetic variation inthese two genes might play at best a limited role inbreast and prostate cancers.",
author = "Hsin-Chung Cheng",
year = "2004",
language = "繁體中文",
publisher = "臺視文化",

}

TY - BOOK

T1 - 一口好牙 : 0-99歲的保健牙典

AU - Cheng, Hsin-Chung

PY - 2004

Y1 - 2004

N2 - Genes involved in the inflammation pathway have been associated with cancer risk. Genetic variants in the interleukin-6 (IL6) and prostaglandin-endoperoxidesynthase-2 (PTGS2, encoding for the COX-2 enzyme) genes, in particular, have been related to several cancer types, including breast and prostate cancers. Weconducted a study within the Breast and Prostate Cancer Cohort Consortium(BPC3) to examine the association between IL6 and PTGS2 polymorphisms and breast and prostate cancer risk. Twenty-seven polymorphisms, selected by pairwise tagging, were genotyped on 6,292 breast cancer cases and 8,135 matched controls and 8,008 prostate cancer cases and 8,604 matched controls. Thelarge sample sizes and comprehensive SNP tagging in thisstudy gave us excellent power to detect modest effectsfor common variants. After adjustment for multipletesting, none of the associations examined remainedstatistically significant at P = 0.01. In analyses notadjusted for multiple testing, one IL6 polymorphism(rs6949149) was marginally associated with breast cancerrisk (TT vs. GG, OR: 1.32; 99% CI: 1.00-1.74,P(trend)=0.003) and two were marginally associated withprostate cancer risk (rs6969502-AA versus rs6969502-GG,OR: 0.87, 99% CI: 0.75-1.02; P(trend) = 0.002 andrs7805828-AA vs. rs7805828-GG, OR: 1.11, 99% CI: 0.99-1.26; P(trend) = 0.007). An increase in breast cancerrisk was observed for the PTGS2 polymorphism rs7550380(TT vs. GG, OR: 1.38, 99% CI: 1.04-1.83). No associationwas observed between PTGS2 polymorphisms and prostatecancer risk. In conclusion, common genetic variation inthese two genes might play at best a limited role inbreast and prostate cancers.

AB - Genes involved in the inflammation pathway have been associated with cancer risk. Genetic variants in the interleukin-6 (IL6) and prostaglandin-endoperoxidesynthase-2 (PTGS2, encoding for the COX-2 enzyme) genes, in particular, have been related to several cancer types, including breast and prostate cancers. Weconducted a study within the Breast and Prostate Cancer Cohort Consortium(BPC3) to examine the association between IL6 and PTGS2 polymorphisms and breast and prostate cancer risk. Twenty-seven polymorphisms, selected by pairwise tagging, were genotyped on 6,292 breast cancer cases and 8,135 matched controls and 8,008 prostate cancer cases and 8,604 matched controls. Thelarge sample sizes and comprehensive SNP tagging in thisstudy gave us excellent power to detect modest effectsfor common variants. After adjustment for multipletesting, none of the associations examined remainedstatistically significant at P = 0.01. In analyses notadjusted for multiple testing, one IL6 polymorphism(rs6949149) was marginally associated with breast cancerrisk (TT vs. GG, OR: 1.32; 99% CI: 1.00-1.74,P(trend)=0.003) and two were marginally associated withprostate cancer risk (rs6969502-AA versus rs6969502-GG,OR: 0.87, 99% CI: 0.75-1.02; P(trend) = 0.002 andrs7805828-AA vs. rs7805828-GG, OR: 1.11, 99% CI: 0.99-1.26; P(trend) = 0.007). An increase in breast cancerrisk was observed for the PTGS2 polymorphism rs7550380(TT vs. GG, OR: 1.38, 99% CI: 1.04-1.83). No associationwas observed between PTGS2 polymorphisms and prostatecancer risk. In conclusion, common genetic variation inthese two genes might play at best a limited role inbreast and prostate cancers.

UR - https://www.worldcat.org/title/yi-kou-hao-ya-0-99-sui-de-bao-jian-ya-dian/oclc/816124550&referer=brief_results

M3 - 書籍

BT - 一口好牙 : 0-99歲的保健牙典

PB - 臺視文化

ER -