Yes-associated protein is not an independent prognostic marker in breast cancer

Shyr Ming Sheen-Chen, Chun Ying Huang, Ching Hua Tsai, Yueh Wei Liu, Shih Chung Wu, Chao Cheng Huang, Hock Liew Eng, Yi Chia Chan, Sheung Fat Ko, Rei Ping Tang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: The development of tissue microarray (TMA) technology has provided the opportunity to perform analyses of tissue samples on a large scale in an uniform fashion. This study was designed with the use of TMA to explore the Yes-associated protein (YAP) status in breast cancer. Patients and Methods: YAP expression in tumor and tumor-free samples from 94 patients with primary breast cancer was analyzed by TMA. The clinicopathological data for age, estrogen receptor status, histological grading and TNM staging were also collected. Results: There were 29 patients (30.8%) with 1+ expression, in YAP, 59 patients (62.8%) with 2+ expression and 6 (6.4%) with 3+ expression. There was no significant relationship between YAP expression and the other clinicopathological variables. By multivariate analysis, YAP expression failed to produce any significant relationship with the overall survival rate. Conclusion: YAP expression is not an independent prognostic factor in patients with breast cancer.

Original languageEnglish
Pages (from-to)3321-3326
Number of pages6
JournalAnticancer Research
Volume32
Issue number8
Publication statusPublished - Aug 1 2012

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Breast Neoplasms
Proteins
Neoplasm Staging
Estrogen Receptors
Neoplasms
Multivariate Analysis
Survival Rate
Technology

Keywords

  • Breast cancer
  • Tissue microarray
  • Yes-assosiated protein

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Sheen-Chen, S. M., Huang, C. Y., Tsai, C. H., Liu, Y. W., Wu, S. C., Huang, C. C., ... Tang, R. P. (2012). Yes-associated protein is not an independent prognostic marker in breast cancer. Anticancer Research, 32(8), 3321-3326.

Yes-associated protein is not an independent prognostic marker in breast cancer. / Sheen-Chen, Shyr Ming; Huang, Chun Ying; Tsai, Ching Hua; Liu, Yueh Wei; Wu, Shih Chung; Huang, Chao Cheng; Eng, Hock Liew; Chan, Yi Chia; Ko, Sheung Fat; Tang, Rei Ping.

In: Anticancer Research, Vol. 32, No. 8, 01.08.2012, p. 3321-3326.

Research output: Contribution to journalArticle

Sheen-Chen, SM, Huang, CY, Tsai, CH, Liu, YW, Wu, SC, Huang, CC, Eng, HL, Chan, YC, Ko, SF & Tang, RP 2012, 'Yes-associated protein is not an independent prognostic marker in breast cancer', Anticancer Research, vol. 32, no. 8, pp. 3321-3326.
Sheen-Chen, Shyr Ming ; Huang, Chun Ying ; Tsai, Ching Hua ; Liu, Yueh Wei ; Wu, Shih Chung ; Huang, Chao Cheng ; Eng, Hock Liew ; Chan, Yi Chia ; Ko, Sheung Fat ; Tang, Rei Ping. / Yes-associated protein is not an independent prognostic marker in breast cancer. In: Anticancer Research. 2012 ; Vol. 32, No. 8. pp. 3321-3326.
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AU - Huang, Chao Cheng

AU - Eng, Hock Liew

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AU - Ko, Sheung Fat

AU - Tang, Rei Ping

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