Yes-associated protein is not an independent prognostic marker in breast cancer

Shyr Ming Sheen-Chen, Chun Ying Huang, Ching Hua Tsai, Yueh Wei Liu, Shih Chung Wu, Chao Cheng Huang, Hock Liew Eng, Yi Chia Chan, Sheung Fat Ko, Rei Ping Tang

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Background: The development of tissue microarray (TMA) technology has provided the opportunity to perform analyses of tissue samples on a large scale in an uniform fashion. This study was designed with the use of TMA to explore the Yes-associated protein (YAP) status in breast cancer. Patients and Methods: YAP expression in tumor and tumor-free samples from 94 patients with primary breast cancer was analyzed by TMA. The clinicopathological data for age, estrogen receptor status, histological grading and TNM staging were also collected. Results: There were 29 patients (30.8%) with 1+ expression, in YAP, 59 patients (62.8%) with 2+ expression and 6 (6.4%) with 3+ expression. There was no significant relationship between YAP expression and the other clinicopathological variables. By multivariate analysis, YAP expression failed to produce any significant relationship with the overall survival rate. Conclusion: YAP expression is not an independent prognostic factor in patients with breast cancer.

Original languageEnglish
Pages (from-to)3321-3326
Number of pages6
JournalAnticancer Research
Volume32
Issue number8
Publication statusPublished - Aug 1 2012

Keywords

  • Breast cancer
  • Tissue microarray
  • Yes-assosiated protein

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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