XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium

Pei Liang Chen, Kun Tu Yeh, Yi Yu Tsai, Hank Koeh, Yu Ling Liu, Huei Lee, Ya Wen Cheng

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Purpose: Epidemiological evidence suggests that UV irradiation plays an important role in pterygium pathogenesis. UV irradiation can produce a wide range of DNA damage. The base excision repair (BER) pathway is considered the most important pathway involved in the repair of radiation-induced DNA damage. Based on previous studies, single-nucleotide polymorphisms (SNPs) in 8-oxoguanine glycosylase-1 (OGG1), X-ray repair cross-complementing-1 (XRCC1), and APendonuclease-1 (APE1) genes in the BER pathway have been found to affect the individual sensitivity to radiation exposure and induction of DNA damage. Therefore, we hypothesize that the genetic polymorphisms of these repair genes increase the risk of pterygium. Methods: XRCC1, APE1, and hOGG1 polymorphisms were studied using fluorescence-labeled Taq Man probes on 83 pterygial specimens and 206 normal controls. Results: There was a significant difference between the case and control groups in the XRCC1 genotype (p=0.038) but not in hOGG1 (p=0.383) and APE1 (p=0.898). The odds ratio of the XRCC1 A/G polymorphism was 2.592 (95% CI=1.225-5.484, p=0.013) and the G/G polymorphism was 1.212 (95% CI=0.914-1.607), compared to the A/A wild-type genotype. Moreover, individuals who carried at least one C-allele (A/G and G/G) had a 1.710 fold increased risk of developing pterygium compared to those who carried the A/A wild type genotype (OR=1.710; 95% CI: 1.015-2.882, p=0.044). The hOGG1 and APE1 polymorphisms did not have an increased odds ratio compared with the wild type. Conclusions: XRCC1 (Arg399 Glu) is correlated with pterygium and might become a potential marker for the prediction of pterygium susceptibility.

Original languageEnglish
Pages (from-to)991-996
Number of pages6
JournalMolecular Vision
Volume16
Publication statusPublished - 2010
Externally publishedYes

Fingerprint

Pterygium
X-Rays
DNA Damage
Genes
Genotype
DNA Repair
Odds Ratio
Genetic Polymorphisms
Single Nucleotide Polymorphism
Fluorescence
Alleles
Radiation
Control Groups

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Chen, P. L., Yeh, K. T., Tsai, Y. Y., Koeh, H., Liu, Y. L., Lee, H., & Cheng, Y. W. (2010). XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium. Molecular Vision, 16, 991-996.

XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium. / Chen, Pei Liang; Yeh, Kun Tu; Tsai, Yi Yu; Koeh, Hank; Liu, Yu Ling; Lee, Huei; Cheng, Ya Wen.

In: Molecular Vision, Vol. 16, 2010, p. 991-996.

Research output: Contribution to journalArticle

Chen, PL, Yeh, KT, Tsai, YY, Koeh, H, Liu, YL, Lee, H & Cheng, YW 2010, 'XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium', Molecular Vision, vol. 16, pp. 991-996.
Chen PL, Yeh KT, Tsai YY, Koeh H, Liu YL, Lee H et al. XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium. Molecular Vision. 2010;16:991-996.
Chen, Pei Liang ; Yeh, Kun Tu ; Tsai, Yi Yu ; Koeh, Hank ; Liu, Yu Ling ; Lee, Huei ; Cheng, Ya Wen. / XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium. In: Molecular Vision. 2010 ; Vol. 16. pp. 991-996.
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abstract = "Purpose: Epidemiological evidence suggests that UV irradiation plays an important role in pterygium pathogenesis. UV irradiation can produce a wide range of DNA damage. The base excision repair (BER) pathway is considered the most important pathway involved in the repair of radiation-induced DNA damage. Based on previous studies, single-nucleotide polymorphisms (SNPs) in 8-oxoguanine glycosylase-1 (OGG1), X-ray repair cross-complementing-1 (XRCC1), and APendonuclease-1 (APE1) genes in the BER pathway have been found to affect the individual sensitivity to radiation exposure and induction of DNA damage. Therefore, we hypothesize that the genetic polymorphisms of these repair genes increase the risk of pterygium. Methods: XRCC1, APE1, and hOGG1 polymorphisms were studied using fluorescence-labeled Taq Man probes on 83 pterygial specimens and 206 normal controls. Results: There was a significant difference between the case and control groups in the XRCC1 genotype (p=0.038) but not in hOGG1 (p=0.383) and APE1 (p=0.898). The odds ratio of the XRCC1 A/G polymorphism was 2.592 (95{\%} CI=1.225-5.484, p=0.013) and the G/G polymorphism was 1.212 (95{\%} CI=0.914-1.607), compared to the A/A wild-type genotype. Moreover, individuals who carried at least one C-allele (A/G and G/G) had a 1.710 fold increased risk of developing pterygium compared to those who carried the A/A wild type genotype (OR=1.710; 95{\%} CI: 1.015-2.882, p=0.044). The hOGG1 and APE1 polymorphisms did not have an increased odds ratio compared with the wild type. Conclusions: XRCC1 (Arg399 Glu) is correlated with pterygium and might become a potential marker for the prediction of pterygium susceptibility.",
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T1 - XRCC1, but not APE1 and hOGG1 gene polymorphisms is a risk factor for pterygium

AU - Chen, Pei Liang

AU - Yeh, Kun Tu

AU - Tsai, Yi Yu

AU - Koeh, Hank

AU - Liu, Yu Ling

AU - Lee, Huei

AU - Cheng, Ya Wen

PY - 2010

Y1 - 2010

N2 - Purpose: Epidemiological evidence suggests that UV irradiation plays an important role in pterygium pathogenesis. UV irradiation can produce a wide range of DNA damage. The base excision repair (BER) pathway is considered the most important pathway involved in the repair of radiation-induced DNA damage. Based on previous studies, single-nucleotide polymorphisms (SNPs) in 8-oxoguanine glycosylase-1 (OGG1), X-ray repair cross-complementing-1 (XRCC1), and APendonuclease-1 (APE1) genes in the BER pathway have been found to affect the individual sensitivity to radiation exposure and induction of DNA damage. Therefore, we hypothesize that the genetic polymorphisms of these repair genes increase the risk of pterygium. Methods: XRCC1, APE1, and hOGG1 polymorphisms were studied using fluorescence-labeled Taq Man probes on 83 pterygial specimens and 206 normal controls. Results: There was a significant difference between the case and control groups in the XRCC1 genotype (p=0.038) but not in hOGG1 (p=0.383) and APE1 (p=0.898). The odds ratio of the XRCC1 A/G polymorphism was 2.592 (95% CI=1.225-5.484, p=0.013) and the G/G polymorphism was 1.212 (95% CI=0.914-1.607), compared to the A/A wild-type genotype. Moreover, individuals who carried at least one C-allele (A/G and G/G) had a 1.710 fold increased risk of developing pterygium compared to those who carried the A/A wild type genotype (OR=1.710; 95% CI: 1.015-2.882, p=0.044). The hOGG1 and APE1 polymorphisms did not have an increased odds ratio compared with the wild type. Conclusions: XRCC1 (Arg399 Glu) is correlated with pterygium and might become a potential marker for the prediction of pterygium susceptibility.

AB - Purpose: Epidemiological evidence suggests that UV irradiation plays an important role in pterygium pathogenesis. UV irradiation can produce a wide range of DNA damage. The base excision repair (BER) pathway is considered the most important pathway involved in the repair of radiation-induced DNA damage. Based on previous studies, single-nucleotide polymorphisms (SNPs) in 8-oxoguanine glycosylase-1 (OGG1), X-ray repair cross-complementing-1 (XRCC1), and APendonuclease-1 (APE1) genes in the BER pathway have been found to affect the individual sensitivity to radiation exposure and induction of DNA damage. Therefore, we hypothesize that the genetic polymorphisms of these repair genes increase the risk of pterygium. Methods: XRCC1, APE1, and hOGG1 polymorphisms were studied using fluorescence-labeled Taq Man probes on 83 pterygial specimens and 206 normal controls. Results: There was a significant difference between the case and control groups in the XRCC1 genotype (p=0.038) but not in hOGG1 (p=0.383) and APE1 (p=0.898). The odds ratio of the XRCC1 A/G polymorphism was 2.592 (95% CI=1.225-5.484, p=0.013) and the G/G polymorphism was 1.212 (95% CI=0.914-1.607), compared to the A/A wild-type genotype. Moreover, individuals who carried at least one C-allele (A/G and G/G) had a 1.710 fold increased risk of developing pterygium compared to those who carried the A/A wild type genotype (OR=1.710; 95% CI: 1.015-2.882, p=0.044). The hOGG1 and APE1 polymorphisms did not have an increased odds ratio compared with the wild type. Conclusions: XRCC1 (Arg399 Glu) is correlated with pterygium and might become a potential marker for the prediction of pterygium susceptibility.

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