Worsen depression after viscosupplementation treatment for geriatric people with knee osteoarthritis?

Yu Pin Chen, Shu Mei Wang, Yueh Wu, Hsin Yu Lin, Cheng Chun Wu, Tai Yuan Chuang, Wei Pin Ho, Yi Jie Kuo, Tsai Hsueh Leu, Chung Ying Lin

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Background/objective: Knee osteoarthritis (OA) in older people may result in psychological impairment, including anxiety and depression. This study investigates the effect of intraarticular hyaluronic acid injection (IAHA) on geriatric patients with OA. Method: A total of 102 geriatric patients with knee OA undergoing IAHA were prospectively enrolled in this study. Geriatric Depression Scale (GDS), State-Trait Anxiety Inventory (STAI), Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and the International Knee Documentation Committee Subjective Knee Evaluation Form (IKDC), and Visual Analogue Scale (VAS) for pain were recorded. All outcomes were measured at baseline before injection and during two, four, and six month follow-ups. Results: IAHA had a significant short-term effect, relieving pain at the two month follow-up, but the effect was weaker at the four month follow-up. Both IKDC and WOMAC scores were significantly improved at the two month follow-up. Viscosupplementation did not improve STAI. GDS exhibited significant deterioration at the four month follow-up. Conclusions: Although IAHA for the treatment of OA provided short-term efficiency, it had no effects on anxiety and increased depression of geriatric people. Health education should be provided with caution before viscosupplementation treatment to manage expectations of the efficacy of treatment for geriatric OA patients.

Original languageEnglish
Pages (from-to)31-40
Number of pages10
JournalInternational Journal of Clinical and Health Psychology
Issue number1
Publication statusPublished - Jan 2019


  • Depression
  • Hyaluronic acid
  • Osteoarthritis
  • Quasi-experiment

ASJC Scopus subject areas

  • Clinical Psychology


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