TY - JOUR
T1 - Why context matters? Divisive normalization and canonical microcircuits in psychiatric disorders
AU - Northoff, Georg
AU - Mushiake, Hajime
N1 - Funding Information:
GN is thankful to Canada Institute of Health Research , EJLB-CIHR , and National Science Foundation/China for financial support, while HM is grateful to CREST and Japan Science Technology for financial support. We are also thankful to Niall Duncan, Fransesca Ferri, Zirui Huang, Annemarie Wolf, Niall Duncan, and Andre Longtin for very helpful comments on prior drafts of the paper, as well to Wendy Carter for putting the references together.
Publisher Copyright:
© 2019 Elsevier B.V. and Japan Neuroscience Society
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/7
Y1 - 2020/7
N2 - Neural activity on cellular, regional, and behavioral levels shows context-dependence. Here we suggest the processing of input-output relationships in terms divisive normalization (DN), including (i) summing/averaging inputs and (ii) normalizing output against input stages, as a computational mechanism to underlie context-dependence. Input summation and output normalization are mediated by input-output relationships in canonical microcircuits (CM). DN/CM are altered in psychiatric disorders like schizophrenia or depression whose various symptoms can be characterized by abnormal context-dependence.
AB - Neural activity on cellular, regional, and behavioral levels shows context-dependence. Here we suggest the processing of input-output relationships in terms divisive normalization (DN), including (i) summing/averaging inputs and (ii) normalizing output against input stages, as a computational mechanism to underlie context-dependence. Input summation and output normalization are mediated by input-output relationships in canonical microcircuits (CM). DN/CM are altered in psychiatric disorders like schizophrenia or depression whose various symptoms can be characterized by abnormal context-dependence.
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U2 - 10.1016/j.neures.2019.10.002
DO - 10.1016/j.neures.2019.10.002
M3 - Review article
C2 - 31628970
AN - SCOPUS:85074358452
SN - 0168-0102
VL - 156
SP - 130
EP - 140
JO - Neuroscience Research
JF - Neuroscience Research
ER -