Why context matters? Divisive normalization and canonical microcircuits in psychiatric disorders

Georg Northoff, Hajime Mushiake

Research output: Contribution to journalReview article


Neural activity on cellular, regional, and behavioral levels shows context-dependence. Here we suggest the processing of input-output relationships in terms divisive normalization (DN), including (i) summing/averaging inputs and (ii) normalizing output against input stages, as a computational mechanism to underlie context-dependence. Input summation and output normalization are mediated by input-output relationships in canonical microcircuits (CM). DN/CM are altered in psychiatric disorders like schizophrenia or depression whose various symptoms can be characterized by abnormal context-dependence.

Original languageEnglish
JournalNeuroscience Research
Publication statusAccepted/In press - Jan 1 2019


ASJC Scopus subject areas

  • Neuroscience(all)

Cite this