White Matter Deficits Underlying the Impaired Consciousness Level in Patients with Disorders of Consciousness

Xuehai Wu, Jiaying Zhang, Zaixu Cui, Weijun Tang, Chunhong Shao, Jin Hu, Jianhong Zhu, Yao Zhao, Lu Lu, Gang Chen, Georg Northoff, Gaolang Gong, Ying Mao, Yong He

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In this study, we aimed to (1) identify white matter (WM) deficits underlying the consciousness level in patients with disorders of consciousness (DOCs) using diffusion tensor imaging (DTI), and (2) evaluate the relationship between DTI metrics and clinical measures of the consciousness level in DOC patients. With a cohort of 8 comatose, 8 unresponsive wakefulness syndrome/vegetative state, and 14 minimally conscious state patients and 25 patient controls, we performed group comparisons of the DTI metrics in 48 core WM regions of interest (ROIs), and examined the clinical relevance using correlation analysis. We identified multiple abnormal WM ROIs in DOC patients compared with normal controls, and the DTI metrics in these ROIs were significantly correlated with clinical measures of the consciousness level. Therefore, our findings suggested that multiple WM tracts are involved in the impaired consciousness levels in DOC patients and demonstrated the clinical relevance of DTI for DOC patients.

Original languageEnglish
Pages (from-to)668-678
Number of pages11
JournalNeuroscience Bulletin
Volume34
Issue number4
DOIs
Publication statusPublished - Aug 1 2018
Externally publishedYes

Fingerprint

Consciousness Disorders
Consciousness
Diffusion Tensor Imaging
Persistent Vegetative State
Wakefulness
Coma
White Matter
Control Groups

Keywords

  • Brain injury
  • Diffusion tensor imaging
  • Disorder of consciousness
  • White matter

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

Cite this

White Matter Deficits Underlying the Impaired Consciousness Level in Patients with Disorders of Consciousness. / Wu, Xuehai; Zhang, Jiaying; Cui, Zaixu; Tang, Weijun; Shao, Chunhong; Hu, Jin; Zhu, Jianhong; Zhao, Yao; Lu, Lu; Chen, Gang; Northoff, Georg; Gong, Gaolang; Mao, Ying; He, Yong.

In: Neuroscience Bulletin, Vol. 34, No. 4, 01.08.2018, p. 668-678.

Research output: Contribution to journalArticle

Wu, X, Zhang, J, Cui, Z, Tang, W, Shao, C, Hu, J, Zhu, J, Zhao, Y, Lu, L, Chen, G, Northoff, G, Gong, G, Mao, Y & He, Y 2018, 'White Matter Deficits Underlying the Impaired Consciousness Level in Patients with Disorders of Consciousness', Neuroscience Bulletin, vol. 34, no. 4, pp. 668-678. https://doi.org/10.1007/s12264-018-0253-3
Wu, Xuehai ; Zhang, Jiaying ; Cui, Zaixu ; Tang, Weijun ; Shao, Chunhong ; Hu, Jin ; Zhu, Jianhong ; Zhao, Yao ; Lu, Lu ; Chen, Gang ; Northoff, Georg ; Gong, Gaolang ; Mao, Ying ; He, Yong. / White Matter Deficits Underlying the Impaired Consciousness Level in Patients with Disorders of Consciousness. In: Neuroscience Bulletin. 2018 ; Vol. 34, No. 4. pp. 668-678.
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