What is new for an old molecule? systematic review and recommendations on the use of resveratrol

Ole Vang, Nihal Ahmad, Clifton A. Baile, Joseph A. Baur, Karen Brown, Anna Csiszar, Dipak K. Das, Dominique Delmas, Carmem Gottfried, Hung Yun Lin, Qing Yong Ma, Partha Mukhopadhyay, Namasivayam Nalini, John M. Pezzuto, Tristan Richard, Yogeshwer Shukla, Young Joon Surh, Thomas Szekeres, Tomasz Szkudelski, Thomas Walle & 1 others Joseph M. Wu

Research output: Contribution to journalReview article

293 Citations (Scopus)

Abstract

Background: Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark. Methodology: Literature search in databases as PubMed and ISI Web of Science in combination with manual search was used to answer the following five questions: 1Can resveratrol be recommended in the prevention or treatment of human diseases?; 2Are there observed "side effects" caused by the intake of resveratrol in humans?; 3What is the relevant dose of resveratrol?; 4What valid data are available regarding an effect in various species of experimental animals?; 5Which relevant (overall) mechanisms of action of resveratrol have been documented? Conclusions/Significance: The overall conclusion is that the published evidence is not sufficiently strong to justify a recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary sources. On the other hand, animal data are promising in prevention of various cancer types, coronary heart diseases and diabetes which strongly indicate the need for human clinical trials. Finally, we suggest directions for future research in resveratrol regarding its mechanism of action and its safety and toxicology in human subjects.

Original languageEnglish
Article numbere19881
JournalPLoS One
Volume6
Issue number6
DOIs
Publication statusPublished - 2011
Externally publishedYes

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resveratrol
systematic review
Molecules
mechanism of action
Animals
toxicology
Denmark
Medical problems
dosage
human diseases
PubMed
Toxicology
Coronary Disease
laboratory animals
diabetes
clinical trials
adverse effects
Health
Clinical Trials
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ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Vang, O., Ahmad, N., Baile, C. A., Baur, J. A., Brown, K., Csiszar, A., ... Wu, J. M. (2011). What is new for an old molecule? systematic review and recommendations on the use of resveratrol. PLoS One, 6(6), [e19881]. https://doi.org/10.1371/journal.pone.0019881

What is new for an old molecule? systematic review and recommendations on the use of resveratrol. / Vang, Ole; Ahmad, Nihal; Baile, Clifton A.; Baur, Joseph A.; Brown, Karen; Csiszar, Anna; Das, Dipak K.; Delmas, Dominique; Gottfried, Carmem; Lin, Hung Yun; Ma, Qing Yong; Mukhopadhyay, Partha; Nalini, Namasivayam; Pezzuto, John M.; Richard, Tristan; Shukla, Yogeshwer; Surh, Young Joon; Szekeres, Thomas; Szkudelski, Tomasz; Walle, Thomas; Wu, Joseph M.

In: PLoS One, Vol. 6, No. 6, e19881, 2011.

Research output: Contribution to journalReview article

Vang, O, Ahmad, N, Baile, CA, Baur, JA, Brown, K, Csiszar, A, Das, DK, Delmas, D, Gottfried, C, Lin, HY, Ma, QY, Mukhopadhyay, P, Nalini, N, Pezzuto, JM, Richard, T, Shukla, Y, Surh, YJ, Szekeres, T, Szkudelski, T, Walle, T & Wu, JM 2011, 'What is new for an old molecule? systematic review and recommendations on the use of resveratrol', PLoS One, vol. 6, no. 6, e19881. https://doi.org/10.1371/journal.pone.0019881
Vang, Ole ; Ahmad, Nihal ; Baile, Clifton A. ; Baur, Joseph A. ; Brown, Karen ; Csiszar, Anna ; Das, Dipak K. ; Delmas, Dominique ; Gottfried, Carmem ; Lin, Hung Yun ; Ma, Qing Yong ; Mukhopadhyay, Partha ; Nalini, Namasivayam ; Pezzuto, John M. ; Richard, Tristan ; Shukla, Yogeshwer ; Surh, Young Joon ; Szekeres, Thomas ; Szkudelski, Tomasz ; Walle, Thomas ; Wu, Joseph M. / What is new for an old molecule? systematic review and recommendations on the use of resveratrol. In: PLoS One. 2011 ; Vol. 6, No. 6.
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AU - Vang, Ole

AU - Ahmad, Nihal

AU - Baile, Clifton A.

AU - Baur, Joseph A.

AU - Brown, Karen

AU - Csiszar, Anna

AU - Das, Dipak K.

AU - Delmas, Dominique

AU - Gottfried, Carmem

AU - Lin, Hung Yun

AU - Ma, Qing Yong

AU - Mukhopadhyay, Partha

AU - Nalini, Namasivayam

AU - Pezzuto, John M.

AU - Richard, Tristan

AU - Shukla, Yogeshwer

AU - Surh, Young Joon

AU - Szekeres, Thomas

AU - Szkudelski, Tomasz

AU - Walle, Thomas

AU - Wu, Joseph M.

PY - 2011

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N2 - Background: Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark. Methodology: Literature search in databases as PubMed and ISI Web of Science in combination with manual search was used to answer the following five questions: 1Can resveratrol be recommended in the prevention or treatment of human diseases?; 2Are there observed "side effects" caused by the intake of resveratrol in humans?; 3What is the relevant dose of resveratrol?; 4What valid data are available regarding an effect in various species of experimental animals?; 5Which relevant (overall) mechanisms of action of resveratrol have been documented? Conclusions/Significance: The overall conclusion is that the published evidence is not sufficiently strong to justify a recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary sources. On the other hand, animal data are promising in prevention of various cancer types, coronary heart diseases and diabetes which strongly indicate the need for human clinical trials. Finally, we suggest directions for future research in resveratrol regarding its mechanism of action and its safety and toxicology in human subjects.

AB - Background: Resveratrol is a natural compound suggested to have beneficial health effects. However, people are consuming resveratrol for this reason without having the adequate scientific evidence for its effects in humans. Therefore, scientific valid recommendations concerning the human intake of resveratrol based on available published scientific data are necessary. Such recommendations were formulated after the Resveratrol 2010 conference, held in September 2010 in Helsingør, Denmark. Methodology: Literature search in databases as PubMed and ISI Web of Science in combination with manual search was used to answer the following five questions: 1Can resveratrol be recommended in the prevention or treatment of human diseases?; 2Are there observed "side effects" caused by the intake of resveratrol in humans?; 3What is the relevant dose of resveratrol?; 4What valid data are available regarding an effect in various species of experimental animals?; 5Which relevant (overall) mechanisms of action of resveratrol have been documented? Conclusions/Significance: The overall conclusion is that the published evidence is not sufficiently strong to justify a recommendation for the administration of resveratrol to humans, beyond the dose which can be obtained from dietary sources. On the other hand, animal data are promising in prevention of various cancer types, coronary heart diseases and diabetes which strongly indicate the need for human clinical trials. Finally, we suggest directions for future research in resveratrol regarding its mechanism of action and its safety and toxicology in human subjects.

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