Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene

Dun Jen Hsiao; Lawrence Shih Hsin Wu; Shih Yi Huang; Eugene Lin

doi:10.1097/FPC.0b013e3283307cf1

Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene

Dun Jen Hsiao, Lawrence Shih Hsin Wu, Shih Yi Huang, Eugene Lin

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P

Original language	English
Pages (from-to)	730-733
Number of pages	4
Journal	Pharmacogenetics and Genomics
Volume	19
Issue number	9
DOIs	https://doi.org/10.1097/FPC.0b013e3283307cf1
Publication status	Published - Sep 2009

Keywords

Body fat
Obesity
Sibutramine
Single nucleotide polymorphisms
Weight loss

ASJC Scopus subject areas

Genetics
Molecular Biology
Molecular Medicine
Genetics(clinical)

UN SDGs

This output contributes to the following Sustainable Development Goal(s)

Access to Document

10.1097/FPC.0b013e3283307cf1

Fingerprint Dive into the research topics of 'Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene'. Together they form a unique fingerprint.

Cite this

@article{2e0db9b4a9264f1ba54e96591cfd3c9c,

title = "Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene",

abstract = "The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P",

keywords = "Body fat, Obesity, Sibutramine, Single nucleotide polymorphisms, Weight loss",

author = "Hsiao, {Dun Jen} and Wu, {Lawrence Shih Hsin} and Huang, {Shih Yi} and Eugene Lin",

year = "2009",

month = sep,

doi = "10.1097/FPC.0b013e3283307cf1",

language = "English",

volume = "19",

pages = "730--733",

journal = "Pharmacogenetics",

issn = "1744-6872",

publisher = "Lippincott Williams and Wilkins",

number = "9",

}

TY - JOUR

T1 - Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene

AU - Hsiao, Dun Jen

AU - Wu, Lawrence Shih Hsin

AU - Huang, Shih Yi

AU - Lin, Eugene

PY - 2009/9

Y1 - 2009/9

N2 - The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P

AB - The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P

KW - Body fat

KW - Obesity

KW - Sibutramine

KW - Single nucleotide polymorphisms

KW - Weight loss

UR - http://www.scopus.com/inward/record.url?scp=70249136845&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70249136845&partnerID=8YFLogxK

U2 - 10.1097/FPC.0b013e3283307cf1

DO - 10.1097/FPC.0b013e3283307cf1

M3 - Article

C2 - 19687782

AN - SCOPUS:70249136845

VL - 19

SP - 730

EP - 733

JO - Pharmacogenetics

JF - Pharmacogenetics

SN - 1744-6872

IS - 9

ER -

Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Cite this