Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene

Dun Jen Hsiao, Lawrence Shih Hsin Wu, Shih Yi Huang, Eugene Lin

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P

Original languageEnglish
Pages (from-to)730-733
Number of pages4
JournalPharmacogenetics and Genomics
Volume19
Issue number9
DOIs
Publication statusPublished - Sep 2009

Keywords

  • Body fat
  • Obesity
  • Sibutramine
  • Single nucleotide polymorphisms
  • Weight loss

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Molecular Medicine
  • Genetics(clinical)

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