Abstract
The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P
| Original language | English |
|---|---|
| Pages (from-to) | 730-733 |
| Number of pages | 4 |
| Journal | Pharmacogenetics and Genomics |
| Volume | 19 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2009 |
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Keywords
- Body fat
- Obesity
- Sibutramine
- Single nucleotide polymorphisms
- Weight loss
ASJC Scopus subject areas
- Genetics
- Molecular Biology
- Molecular Medicine
- Genetics(clinical)
Cite this
Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene. / Hsiao, Dun Jen; Wu, Lawrence Shih Hsin; Huang, Shih Yi; Lin, Eugene.
In: Pharmacogenetics and Genomics, Vol. 19, No. 9, 09.2009, p. 730-733.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene
AU - Hsiao, Dun Jen
AU - Wu, Lawrence Shih Hsin
AU - Huang, Shih Yi
AU - Lin, Eugene
PY - 2009/9
Y1 - 2009/9
N2 - The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P
AB - The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P
KW - Body fat
KW - Obesity
KW - Sibutramine
KW - Single nucleotide polymorphisms
KW - Weight loss
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UR - http://www.scopus.com/inward/citedby.url?scp=70249136845&partnerID=8YFLogxK
U2 - 10.1097/FPC.0b013e3283307cf1
DO - 10.1097/FPC.0b013e3283307cf1
M3 - Article
C2 - 19687782
AN - SCOPUS:70249136845
VL - 19
SP - 730
EP - 733
JO - Pharmacogenetics and Genomics
JF - Pharmacogenetics and Genomics
SN - 1744-6872
IS - 9
ER -