Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene

Dun Jen Hsiao, Lawrence Shih Hsin Wu, Shih Yi Huang, Eugene Lin

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P

Original languageEnglish
Pages (from-to)730-733
Number of pages4
JournalPharmacogenetics and Genomics
Volume19
Issue number9
DOIs
Publication statusPublished - Sep 2009

Fingerprint

sibutramine
Guanine Nucleotides
Adipose Tissue
Weight Loss
Carrier Proteins
Obesity
Peptides
Genes
Single Nucleotide Polymorphism
Therapeutics
Body Composition
Placebos

Keywords

  • Body fat
  • Obesity
  • Sibutramine
  • Single nucleotide polymorphisms
  • Weight loss

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Molecular Medicine
  • Genetics(clinical)

Cite this

Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene. / Hsiao, Dun Jen; Wu, Lawrence Shih Hsin; Huang, Shih Yi; Lin, Eugene.

In: Pharmacogenetics and Genomics, Vol. 19, No. 9, 09.2009, p. 730-733.

Research output: Contribution to journalArticle

@article{2e0db9b4a9264f1ba54e96591cfd3c9c,
title = "Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene",
abstract = "The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P",
keywords = "Body fat, Obesity, Sibutramine, Single nucleotide polymorphisms, Weight loss",
author = "Hsiao, {Dun Jen} and Wu, {Lawrence Shih Hsin} and Huang, {Shih Yi} and Eugene Lin",
year = "2009",
month = "9",
doi = "10.1097/FPC.0b013e3283307cf1",
language = "English",
volume = "19",
pages = "730--733",
journal = "Pharmacogenetics and Genomics",
issn = "1744-6872",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene

AU - Hsiao, Dun Jen

AU - Wu, Lawrence Shih Hsin

AU - Huang, Shih Yi

AU - Lin, Eugene

PY - 2009/9

Y1 - 2009/9

N2 - The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P

AB - The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P

KW - Body fat

KW - Obesity

KW - Sibutramine

KW - Single nucleotide polymorphisms

KW - Weight loss

UR - http://www.scopus.com/inward/record.url?scp=70249136845&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70249136845&partnerID=8YFLogxK

U2 - 10.1097/FPC.0b013e3283307cf1

DO - 10.1097/FPC.0b013e3283307cf1

M3 - Article

C2 - 19687782

AN - SCOPUS:70249136845

VL - 19

SP - 730

EP - 733

JO - Pharmacogenetics and Genomics

JF - Pharmacogenetics and Genomics

SN - 1744-6872

IS - 9

ER -