Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene

Dun Jen Hsiao; Lawrence Shih Hsin Wu; Shih Yi Huang; Eugene Lin

doi:10.1097/FPC.0b013e3283307cf1

Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene

Dun Jen Hsiao, Lawrence Shih Hsin Wu, Shih Yi Huang, Eugene Lin

Research output: Contribution to journal › Article

32 Citations (Scopus)

Abstract

The relationship between weight reduction after sibutramine treatment and a single nucleotide polymorphism, rs5443 (C825T), in the guanine nucleotide binding protein β polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 single nucleotide polymorphism could influence weight reduction and body composition change under sibutramine therapy in 131 obese Taiwanese patients. By comparing the sibutramine and placebo groups with analysis of covariance, our data showed a strong effect of sibutramine on weight reduction (7.4±1.4 vs. 3.4±1.2kg; P

Original language	English
Pages (from-to)	730-733
Number of pages	4
Journal	Pharmacogenetics and Genomics
Volume	19
Issue number	9
DOIs	https://doi.org/10.1097/FPC.0b013e3283307cf1
Publication status	Published - Sep 2009

Keywords

Body fat
Obesity
Sibutramine
Single nucleotide polymorphisms
Weight loss

ASJC Scopus subject areas

Genetics
Molecular Biology
Molecular Medicine
Genetics(clinical)

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