Volume and neuron number of the mediodorsal thalamic nucleus in schizophrenia: A replication study

Peter Danos, Andrea Schmidt, Bruno Baumann, Hans Gert Bernstein, Georg Northoff, Renate Stauch, Dieter Krell, Bernhard Bogerts

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Previous neuropathological studies on the mediodorsal thalamic nucleus (MD) in schizophrenia have yielded conflicting results. While some studies suggested that patients with schizophrenia have a pronounced reduction of the volume and neuron number in the MD, more recent data have not found anatomical alterations in this thalamic nucleus. However, most studies have considerable methodological shortcomings. In the present study, we investigated the volume, neuron density and neuron number in the left and right MD in patients with schizophrenia (n = 20) and normal control subjects without neuropsychiatric disorders (n = 18). Patients with schizophrenia showed no significant difference in neuron density and total neuron number in the MD. Compared with the control group, patients with schizophrenia had a smaller MD volume in both hemispheres, a difference that approached significance in the left MD (- 7.3%) when the whole brain volume was included as a covariate. No significant main group effect of diagnosis was found for the right MD volume. There were no significant correlations between MD volume, neuron density, total neuron number and the duration of illness or the age of the patients. Taken together, the present results suggest that schizophrenia is associated with a moderate volume reduction in the left mediodorsal thalamic nucleus, while the neuron density and the total neuron number are unchanged.

Original languageEnglish
Pages (from-to)281-289
Number of pages9
JournalPsychiatry Research - Neuroimaging
Volume140
Issue number3
DOIs
Publication statusPublished - Dec 30 2005

Fingerprint

Mediodorsal Thalamic Nucleus
Schizophrenia
Neurons
Thalamic Nuclei
Control Groups

Keywords

  • Neuropathology
  • Postmortem
  • Psychosis
  • Thalamus

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Biological Psychiatry
  • Psychology(all)

Cite this

Volume and neuron number of the mediodorsal thalamic nucleus in schizophrenia : A replication study. / Danos, Peter; Schmidt, Andrea; Baumann, Bruno; Bernstein, Hans Gert; Northoff, Georg; Stauch, Renate; Krell, Dieter; Bogerts, Bernhard.

In: Psychiatry Research - Neuroimaging, Vol. 140, No. 3, 30.12.2005, p. 281-289.

Research output: Contribution to journalArticle

Danos, Peter ; Schmidt, Andrea ; Baumann, Bruno ; Bernstein, Hans Gert ; Northoff, Georg ; Stauch, Renate ; Krell, Dieter ; Bogerts, Bernhard. / Volume and neuron number of the mediodorsal thalamic nucleus in schizophrenia : A replication study. In: Psychiatry Research - Neuroimaging. 2005 ; Vol. 140, No. 3. pp. 281-289.
@article{12cf458d3d654700ba4d9e7ebf014505,
title = "Volume and neuron number of the mediodorsal thalamic nucleus in schizophrenia: A replication study",
abstract = "Previous neuropathological studies on the mediodorsal thalamic nucleus (MD) in schizophrenia have yielded conflicting results. While some studies suggested that patients with schizophrenia have a pronounced reduction of the volume and neuron number in the MD, more recent data have not found anatomical alterations in this thalamic nucleus. However, most studies have considerable methodological shortcomings. In the present study, we investigated the volume, neuron density and neuron number in the left and right MD in patients with schizophrenia (n = 20) and normal control subjects without neuropsychiatric disorders (n = 18). Patients with schizophrenia showed no significant difference in neuron density and total neuron number in the MD. Compared with the control group, patients with schizophrenia had a smaller MD volume in both hemispheres, a difference that approached significance in the left MD (- 7.3{\%}) when the whole brain volume was included as a covariate. No significant main group effect of diagnosis was found for the right MD volume. There were no significant correlations between MD volume, neuron density, total neuron number and the duration of illness or the age of the patients. Taken together, the present results suggest that schizophrenia is associated with a moderate volume reduction in the left mediodorsal thalamic nucleus, while the neuron density and the total neuron number are unchanged.",
keywords = "Neuropathology, Postmortem, Psychosis, Thalamus",
author = "Peter Danos and Andrea Schmidt and Bruno Baumann and Bernstein, {Hans Gert} and Georg Northoff and Renate Stauch and Dieter Krell and Bernhard Bogerts",
year = "2005",
month = "12",
day = "30",
doi = "10.1016/j.pscychresns.2005.09.005",
language = "English",
volume = "140",
pages = "281--289",
journal = "Psychiatry Research - Neuroimaging",
issn = "0925-4927",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Volume and neuron number of the mediodorsal thalamic nucleus in schizophrenia

T2 - A replication study

AU - Danos, Peter

AU - Schmidt, Andrea

AU - Baumann, Bruno

AU - Bernstein, Hans Gert

AU - Northoff, Georg

AU - Stauch, Renate

AU - Krell, Dieter

AU - Bogerts, Bernhard

PY - 2005/12/30

Y1 - 2005/12/30

N2 - Previous neuropathological studies on the mediodorsal thalamic nucleus (MD) in schizophrenia have yielded conflicting results. While some studies suggested that patients with schizophrenia have a pronounced reduction of the volume and neuron number in the MD, more recent data have not found anatomical alterations in this thalamic nucleus. However, most studies have considerable methodological shortcomings. In the present study, we investigated the volume, neuron density and neuron number in the left and right MD in patients with schizophrenia (n = 20) and normal control subjects without neuropsychiatric disorders (n = 18). Patients with schizophrenia showed no significant difference in neuron density and total neuron number in the MD. Compared with the control group, patients with schizophrenia had a smaller MD volume in both hemispheres, a difference that approached significance in the left MD (- 7.3%) when the whole brain volume was included as a covariate. No significant main group effect of diagnosis was found for the right MD volume. There were no significant correlations between MD volume, neuron density, total neuron number and the duration of illness or the age of the patients. Taken together, the present results suggest that schizophrenia is associated with a moderate volume reduction in the left mediodorsal thalamic nucleus, while the neuron density and the total neuron number are unchanged.

AB - Previous neuropathological studies on the mediodorsal thalamic nucleus (MD) in schizophrenia have yielded conflicting results. While some studies suggested that patients with schizophrenia have a pronounced reduction of the volume and neuron number in the MD, more recent data have not found anatomical alterations in this thalamic nucleus. However, most studies have considerable methodological shortcomings. In the present study, we investigated the volume, neuron density and neuron number in the left and right MD in patients with schizophrenia (n = 20) and normal control subjects without neuropsychiatric disorders (n = 18). Patients with schizophrenia showed no significant difference in neuron density and total neuron number in the MD. Compared with the control group, patients with schizophrenia had a smaller MD volume in both hemispheres, a difference that approached significance in the left MD (- 7.3%) when the whole brain volume was included as a covariate. No significant main group effect of diagnosis was found for the right MD volume. There were no significant correlations between MD volume, neuron density, total neuron number and the duration of illness or the age of the patients. Taken together, the present results suggest that schizophrenia is associated with a moderate volume reduction in the left mediodorsal thalamic nucleus, while the neuron density and the total neuron number are unchanged.

KW - Neuropathology

KW - Postmortem

KW - Psychosis

KW - Thalamus

UR - http://www.scopus.com/inward/record.url?scp=27844438460&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27844438460&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2005.09.005

DO - 10.1016/j.pscychresns.2005.09.005

M3 - Article

C2 - 16297604

AN - SCOPUS:27844438460

VL - 140

SP - 281

EP - 289

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

IS - 3

ER -