Vitamin d deficiency is associated with severity of dry eye symptoms and primary sjögren’s syndrome: A systematic review and meta-analysis

Che Yuan Kuo, Yu Chen Huang, Ko Jo Lin, Tsung Yu Tsai

Research output: Contribution to journalArticlepeer-review

Abstract

We aimed to examine the correlations between vitamin D deficiency, severity of dry eye symptoms and primary Sjögren’s syndrome (pSS) by performing a systematic review and meta-analysis. Online databases (PubMed, Cochrane Library, and Embase) were searched to identify controlled studies comparing (1) severity of dry eye symptoms between participants with and without vitamin D deficiency; and (2) serum vitamin D levels between patients with and without pSS. Eighteen studies were included. Overall, individuals with vitamin D deficiency had shorter tear breakup time (TBUT), lower Schirmer’s test scores and higher ocular surface disease index (OSDI) score than those without vitamin D deficiency. Additionally, serum vitamin D levels were found to be lower in pSS than controls. Our findings highlight the importance of vitamin D deficiency in the severity of dry eye symptoms and pSS.

Original languageEnglish
Pages (from-to)386-388
Number of pages3
JournalJournal of Nutritional Science and Vitaminology
Volume66
Issue number4
DOIs
Publication statusPublished - 2020

Keywords

  • Interleukin 6
  • Ocular surface disease index
  • Schirmer’s test
  • Tear breakup time
  • Th1 cells
  • Th17 cells

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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