Vitamin D and immune function in chronic kidney disease

Wen Chih Liu, Cai Mei Zheng, Chien Lin Lu, Yuh Feng Lin, Jia Fwu Shyu, Chia Chao Wu, Kuo Cheng Lu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The common causes of death in chronic kidney disease (CKD) patients are cardiovascular events and infectious disease. These patients are also predisposed to the development of vitamin D deficiency, which leads to an increased risk of immune dysfunction. Many extra-renal cells possess the capability to produce local active 1,25(OH)2D in an intracrine or paracrine fashion, even without kidney function. Vitamin D affects both the innate and adaptive immune systems. In innate immunity, vitamin D promotes production of cathelicidin and β-defensin 2 and enhances the capacity for autophagy via toll-like receptor activation as well as affects complement concentrations. In adaptive immunity, vitamin D suppresses the maturation of dendritic cells and weakens antigen presentation. Vitamin D also increases T helper (Th) 2 cytokine production and the efficiency of Treg lymphocytes but suppresses the secretion of Th1 and Th17 cytokines. In addition, vitamin D can decrease autoimmune disease activity. Vitamin D has been shown to play an important role in maintaining normal immune function and crosstalk between the innate and adaptive immune systems. Vitamin D deficiency may also contribute to deterioration of immune function and infectious disorders in CKD patients. However, it needs more evidence to support the requirements for vitamin D supplementation.

Original languageEnglish
Article number14073
Pages (from-to)135-144
Number of pages10
JournalClinica Chimica Acta
Volume450
DOIs
Publication statusPublished - Oct 23 2015

Fingerprint

Chronic Renal Insufficiency
Vitamin D
Vitamin D Deficiency
Immune system
Immune System
Cytokines
Defensins
Kidney
Toll-Like Receptors
Autophagy
Antigen Presentation
Adaptive Immunity
Innate Immunity
Dendritic Cells
Autoimmune Diseases
Lymphocytes
Communicable Diseases
Cause of Death
Crosstalk
Cardiovascular Diseases

Keywords

  • Adaptive immunity
  • Chronic kidney disease
  • Innate immunity
  • Vitamin D

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Vitamin D and immune function in chronic kidney disease. / Liu, Wen Chih; Zheng, Cai Mei; Lu, Chien Lin; Lin, Yuh Feng; Shyu, Jia Fwu; Wu, Chia Chao; Lu, Kuo Cheng.

In: Clinica Chimica Acta, Vol. 450, 14073, 23.10.2015, p. 135-144.

Research output: Contribution to journalArticle

Liu, Wen Chih ; Zheng, Cai Mei ; Lu, Chien Lin ; Lin, Yuh Feng ; Shyu, Jia Fwu ; Wu, Chia Chao ; Lu, Kuo Cheng. / Vitamin D and immune function in chronic kidney disease. In: Clinica Chimica Acta. 2015 ; Vol. 450. pp. 135-144.
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