Visfatin promotes the metastatic potential of chondrosarcoma cells by stimulating ap-1-dependent mmp-2 production in the mapk pathway

Shih Ya Hung, Chih Yang Lin, Cheng Chieh Yu, Hsien Te Chen, Ming Yu Lien, Yu Wen Huang, Yi Chin Fong, Ju Fang Liu, Shih Wei Wang, Wei Cheng Chen, Chih Hsin Tang

Research output: Contribution to journalArticlepeer-review

Abstract

Chondrosarcoma is a malignant bone tumor that is characterized by high metastatic potential and marked resistance to radiation and chemotherapy. The knowledge that adipokines facilitate the initiation, progression, metastasis, and treatment resistance of various tumors has driven several in vitro and in vivo investigations into the effects of adipokines resistin, leptin, and adiponectin upon the development and progression of chondrosarcomas. Another adipokine, visfatin, is known to regulate tumor progression and metastasis, although how this molecule may affect chondrosarcoma metastasis is unclear. Here, we found that visfatin facilitated cellular migration via matrix metalloproteinase-2 (MMP-2) production in human chondrosarcoma cells and overexpression of visfatin enhanced lung metastasis in a mouse model of chondrosarcoma. Visfatin-induced stimulation of MMP-2 synthesis and activation of the AP-1 transcription factor facilitated chondrosarcoma cell migration via the ERK, p38, and JNK signaling pathways. This evidence suggests that visfatin is worth targeting in the treatment of metastatic chondrosarcoma.

Original languageEnglish
Article number8642
JournalInternational journal of molecular sciences
Volume22
Issue number16
DOIs
Publication statusPublished - Aug 2 2021

Keywords

  • AP-1
  • Chondrosarcoma
  • Matrix metalloproteinase-2
  • Metastasis
  • Visfatin

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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