Visfatin-a proinflammatory adipokine-in gallstone disease

Shen Nien Wang, Yao Tsung Yeh, Sen Teh Wang, Shih Chang Chuang, Chao Ling Wang, Ming Lung Yu, King Teh Lee

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Abstract

Background: Visfatin is increasingly associated with several obesity-related diseases. The study is to evaluate if aberrant expression of circulating visfatin occurs in gallstone disease. Methods: An enzyme-linked immunosorbent assay was used to examine serum visfatin levels in 79 patients with cholesterol gallstones, 71 with pigment gallstones, and 223 healthy controls. The chemical composition of extracted gallstones was determined by Fourier transform infrared spectroscopy. Results: Serum visfatin levels were markedly elevated in the cholesterol and pigment gallstones in comparison with healthy controls. Furthermore, increased visfatin levels were associated with formation of the cholesterol and pigment gallstones. Intriguingly, a significant positive correlation between serum visfation levels and white cell count was noted in the cholesterol gallstones and controls. Moreover, the positive correlation in the cholesterol gallstones was more significant in the body mass index ≥25 subgroup than in the body mass index

Original languageEnglish
Pages (from-to)459-465
Number of pages7
JournalAmerican Journal of Surgery
Volume199
Issue number4
DOIs
Publication statusPublished - Apr 2010

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Keywords

  • Adipokine
  • Cholesterol
  • Gallstone
  • Obesity
  • Pigment
  • Visfatin

ASJC Scopus subject areas

  • Surgery

Cite this

Wang, S. N., Yeh, Y. T., Wang, S. T., Chuang, S. C., Wang, C. L., Yu, M. L., & Lee, K. T. (2010). Visfatin-a proinflammatory adipokine-in gallstone disease. American Journal of Surgery, 199(4), 459-465. https://doi.org/10.1016/j.amjsurg.2009.01.014