Abstract
Background: Visfatin is increasingly associated with several obesity-related diseases. The study is to evaluate if aberrant expression of circulating visfatin occurs in gallstone disease. Methods: An enzyme-linked immunosorbent assay was used to examine serum visfatin levels in 79 patients with cholesterol gallstones, 71 with pigment gallstones, and 223 healthy controls. The chemical composition of extracted gallstones was determined by Fourier transform infrared spectroscopy. Results: Serum visfatin levels were markedly elevated in the cholesterol and pigment gallstones in comparison with healthy controls. Furthermore, increased visfatin levels were associated with formation of the cholesterol and pigment gallstones. Intriguingly, a significant positive correlation between serum visfation levels and white cell count was noted in the cholesterol gallstones and controls. Moreover, the positive correlation in the cholesterol gallstones was more significant in the body mass index ≥25 subgroup than in the body mass index
| Original language | English |
|---|---|
| Pages (from-to) | 459-465 |
| Number of pages | 7 |
| Journal | American Journal of Surgery |
| Volume | 199 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2010 |
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Keywords
- Adipokine
- Cholesterol
- Gallstone
- Obesity
- Pigment
- Visfatin
ASJC Scopus subject areas
- Surgery
Cite this
Visfatin-a proinflammatory adipokine-in gallstone disease. / Wang, Shen Nien; Yeh, Yao Tsung; Wang, Sen Teh; Chuang, Shih Chang; Wang, Chao Ling; Yu, Ming Lung; Lee, King Teh.
In: American Journal of Surgery, Vol. 199, No. 4, 04.2010, p. 459-465.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Visfatin-a proinflammatory adipokine-in gallstone disease
AU - Wang, Shen Nien
AU - Yeh, Yao Tsung
AU - Wang, Sen Teh
AU - Chuang, Shih Chang
AU - Wang, Chao Ling
AU - Yu, Ming Lung
AU - Lee, King Teh
PY - 2010/4
Y1 - 2010/4
N2 - Background: Visfatin is increasingly associated with several obesity-related diseases. The study is to evaluate if aberrant expression of circulating visfatin occurs in gallstone disease. Methods: An enzyme-linked immunosorbent assay was used to examine serum visfatin levels in 79 patients with cholesterol gallstones, 71 with pigment gallstones, and 223 healthy controls. The chemical composition of extracted gallstones was determined by Fourier transform infrared spectroscopy. Results: Serum visfatin levels were markedly elevated in the cholesterol and pigment gallstones in comparison with healthy controls. Furthermore, increased visfatin levels were associated with formation of the cholesterol and pigment gallstones. Intriguingly, a significant positive correlation between serum visfation levels and white cell count was noted in the cholesterol gallstones and controls. Moreover, the positive correlation in the cholesterol gallstones was more significant in the body mass index ≥25 subgroup than in the body mass index
AB - Background: Visfatin is increasingly associated with several obesity-related diseases. The study is to evaluate if aberrant expression of circulating visfatin occurs in gallstone disease. Methods: An enzyme-linked immunosorbent assay was used to examine serum visfatin levels in 79 patients with cholesterol gallstones, 71 with pigment gallstones, and 223 healthy controls. The chemical composition of extracted gallstones was determined by Fourier transform infrared spectroscopy. Results: Serum visfatin levels were markedly elevated in the cholesterol and pigment gallstones in comparison with healthy controls. Furthermore, increased visfatin levels were associated with formation of the cholesterol and pigment gallstones. Intriguingly, a significant positive correlation between serum visfation levels and white cell count was noted in the cholesterol gallstones and controls. Moreover, the positive correlation in the cholesterol gallstones was more significant in the body mass index ≥25 subgroup than in the body mass index
KW - Adipokine
KW - Cholesterol
KW - Gallstone
KW - Obesity
KW - Pigment
KW - Visfatin
UR - http://www.scopus.com/inward/record.url?scp=77949912359&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949912359&partnerID=8YFLogxK
U2 - 10.1016/j.amjsurg.2009.01.014
DO - 10.1016/j.amjsurg.2009.01.014
M3 - Article
VL - 199
SP - 459
EP - 465
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
IS - 4
ER -