Virus reactivation in high-risk non-Hodgkin's lymphoma patients after autologous CD34+-selected peripheral blood progenitor cell transplantation

Peng Chan Lin, Ming Yang Lee, Jen Tsun Lin, Liang Tsai Hsiao, Po Min Chen, Tzeon Jye Chiou

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

CD34+-selected peripheral blood progenitor cells (PBPCs) may not only reduce contaminated tumor cells but also compromise immunologic reconstitution and increase incidence of infections after transplantation. We analyzed the incidence of virus reactivation in CD34+-selected PBPCs autologous transplantation. From December 2001 to December 2004, ten high-risk aggressive non-Hodgkin's lymphoma (NHL) patients were enrolled in a program of high-dose chemotherapy plus autologous CD34+-selected PBPCs support. Viral screening studies, including clinical symptoms, physical examinations, hepatitis B virus (HBV)-DNA, cytomegalovirus (CMV)-polymerase chain reaction (PCR), rapid diagnosis of fluorescent antibody stain for herpes-simplex virus (HSV), and viral culture from blood, fluid or tissue were performed weekly during the first 3 months and then monthly for 1 year. Two of four patients (50%) who were HBV carriers developed HBV reactivation. The other two HBV carriers who received prophylactic lamivudine therapy did not develop HBV reactivation. Two patients (20%) developed cytomegalovirus (CMV) infection, and three patients (30%) developed HSV infection in total ten serum-positive patients. The possibility of virus reactivation might increase in NHL patients undergoing autologous CD34+-selected PBPC transplantation. Administering prophylactic antivirus therapy and closely following patient's clinical viral complications should be considered.

Original languageEnglish
Pages (from-to)434-439
Number of pages6
JournalInternational Journal of Hematology
Volume87
Issue number4
DOIs
Publication statusPublished - May 2008
Externally publishedYes

Keywords

  • Autotransplantation
  • CD34-selected PBPCs
  • Non-Hodgkin's lymphoma
  • Virus reactivation

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Virus reactivation in high-risk non-Hodgkin's lymphoma patients after autologous CD34<sup>+</sup>-selected peripheral blood progenitor cell transplantation'. Together they form a unique fingerprint.

Cite this