Virus-like particle systems for vaccine development against viruses in the flaviviridae family

Shu Hui Wong, Alagie Jassey, Jonathan Y. Wang, Wei Cheng Wang, Ching Hsuan Liu, Liang Tzung Lin

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Viruses in the Flaviviridae family are important human and animal pathogens that impose serious threats to global public health. This family of viruses includes emerging and re-emerging viruses, most of which are transmitted by infected mosquito or tick bites. Currently, there is no protective vaccine or effective antiviral treatment against the majority of these viruses, and due to their growing spread, several strategies have been employed to manufacture prophylactic vaccines against these infectious agents including virus-like particle (VLP) subunit vaccines. VLPs are genomeless viral particles that resemble authentic viruses and contain critical repetitive conformational structures on their surface that can trigger the induction of both humoral and cellular responses, making them safe and ideal vaccine candidates against these viruses. In this review, we focus on the potential of the VLP platform in the current vaccine development against the medically important viruses in the Flaviviridae family.

Original languageEnglish
Article number123
JournalVaccines
Volume7
Issue number4
DOIs
Publication statusPublished - Dec 2019

Keywords

  • Flaviviridae
  • Immunogenicity
  • Vaccines
  • Virus-like particles

ASJC Scopus subject areas

  • Immunology
  • Pharmacology
  • Drug Discovery
  • Infectious Diseases
  • Pharmacology (medical)

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