Viral and host proteins involved in picornavirus life cycle

Jing Yi Lin, Tzu Chun Chen, Kuo Feng Weng, Shih Cheng Chang, Li Lien Chen, Shin Ru Shih

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Picornaviruses cause several diseases, not only in humans but also in various animal hosts. For instance, human enteroviruses can cause hand-foot-and-mouth disease, herpangina, myocarditis, acute flaccid paralysis, acute hemorrhagic conjunctivitis, severe neurological complications, including brainstem encephalitis, meningitis and poliomyelitis, and even death. The interaction between the virus and the host is important for viral replication, virulence and pathogenicity. This article reviews studies of the functions of viral and host factors that are involved in the life cycle of picornavirus. The interactions of viral capsid proteins with host cell receptors is discussed first, and the mechanisms by which the viral and host cell factors are involved in viral replication, viral translation and the switch from translation to RNA replication are then addressed. Understanding how cellular proteins interact with viral RNA or viral proteins, as well as the roles of each in viral infection, will provide insights for the design of novel antiviral agents based on these interactions.

Original languageEnglish
Article number103
JournalJournal of Biomedical Science
Volume16
Issue number1
DOIs
Publication statusPublished - 2009
Externally publishedYes

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Picornaviridae
Viral Proteins
Life Cycle Stages
Virulence
Herpangina
Life cycle
Acute Hemorrhagic Conjunctivitis
Hand, Foot and Mouth Disease
Enterovirus
Myocarditis
Viral RNA
Capsid Proteins
Poliomyelitis
Virus Diseases
Encephalitis
Viruses
Meningitis
Paralysis
Brain Stem
Antiviral Agents

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Cell Biology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Pharmacology (medical)

Cite this

Lin, J. Y., Chen, T. C., Weng, K. F., Chang, S. C., Chen, L. L., & Shih, S. R. (2009). Viral and host proteins involved in picornavirus life cycle. Journal of Biomedical Science, 16(1), [103]. https://doi.org/10.1186/1423-0127-16-103

Viral and host proteins involved in picornavirus life cycle. / Lin, Jing Yi; Chen, Tzu Chun; Weng, Kuo Feng; Chang, Shih Cheng; Chen, Li Lien; Shih, Shin Ru.

In: Journal of Biomedical Science, Vol. 16, No. 1, 103, 2009.

Research output: Contribution to journalArticle

Lin, JY, Chen, TC, Weng, KF, Chang, SC, Chen, LL & Shih, SR 2009, 'Viral and host proteins involved in picornavirus life cycle', Journal of Biomedical Science, vol. 16, no. 1, 103. https://doi.org/10.1186/1423-0127-16-103
Lin, Jing Yi ; Chen, Tzu Chun ; Weng, Kuo Feng ; Chang, Shih Cheng ; Chen, Li Lien ; Shih, Shin Ru. / Viral and host proteins involved in picornavirus life cycle. In: Journal of Biomedical Science. 2009 ; Vol. 16, No. 1.
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