Viral and host proteins involved in picornavirus life cycle

Jing Yi Lin, Tzu Chun Chen, Kuo Feng Weng, Shih Cheng Chang, Li Lien Chen, Shin Ru Shih

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Picornaviruses cause several diseases, not only in humans but also in various animal hosts. For instance, human enteroviruses can cause hand-foot-and-mouth disease, herpangina, myocarditis, acute flaccid paralysis, acute hemorrhagic conjunctivitis, severe neurological complications, including brainstem encephalitis, meningitis and poliomyelitis, and even death. The interaction between the virus and the host is important for viral replication, virulence and pathogenicity. This article reviews studies of the functions of viral and host factors that are involved in the life cycle of picornavirus. The interactions of viral capsid proteins with host cell receptors is discussed first, and the mechanisms by which the viral and host cell factors are involved in viral replication, viral translation and the switch from translation to RNA replication are then addressed. Understanding how cellular proteins interact with viral RNA or viral proteins, as well as the roles of each in viral infection, will provide insights for the design of novel antiviral agents based on these interactions.

Original languageEnglish
Article number103
JournalJournal of Biomedical Science
Volume16
Issue number1
DOIs
Publication statusPublished - 2009
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Cell Biology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism
  • Pharmacology (medical)

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  • Cite this

    Lin, J. Y., Chen, T. C., Weng, K. F., Chang, S. C., Chen, L. L., & Shih, S. R. (2009). Viral and host proteins involved in picornavirus life cycle. Journal of Biomedical Science, 16(1), [103]. https://doi.org/10.1186/1423-0127-16-103