Verruciform Xanthoma of the Oral Mucosa-cases Report

Chlung-Fang Huang, Jing-Mrng Hung, Kuang-Hsun Lin, Cheng-Yue Sung, Yr-Jung Lu, Yun-Ho Lin

Research output: Contribution to journalArticle

Abstract

A verruciform xanthoma (VX) is an uncommon lesion confined mainly to the oral mucosa. The diagnosis is almost always made during a histologic examination. Histologically, it is characterized by papillomatosis, parakeratosis, and aggregates of foam cells in the connective tissue papillae. The histogenetic origin of the lipid-laden foam cells is controversial. Three cases of oral mucosal VX are reported, The immunohistochemical study showed that the foam cells were positive for CD68 and vimentin and negative for S-100. Based on our findings, we suggest that foam cells, as a histological hallmark of the lesion, are most likely derived from the monocyte-macrophage lineage. We failed to detect human papillomavirus in all 3 cases. Differentiating a verrucous carcinoma from VX is important, especially in small superficial lesions, which could lead to an inappropriate and excessive surgical intervention. Treatment of VX consists of a simple surgical excision and the prognosis is excellent.
Original languageEnglish
Pages (from-to)226-229
Number of pages4
JournalJournal of Dental Sciences
Volume2
Issue number4
DOIs
Publication statusPublished - Dec 1 2007

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Xanthomatosis
Foam Cells
Mouth Mucosa
Parakeratosis
Verrucous Carcinoma
Papilloma
Vimentin
Connective Tissue
Macrophages
Lipids

Keywords

  • verruciform xanthoma
  • monocyte-macrophage

Cite this

Verruciform Xanthoma of the Oral Mucosa-cases Report. / Huang, Chlung-Fang; Hung, Jing-Mrng; Lin, Kuang-Hsun; Sung, Cheng-Yue; Lu, Yr-Jung; Lin, Yun-Ho.

In: Journal of Dental Sciences, Vol. 2, No. 4, 01.12.2007, p. 226-229.

Research output: Contribution to journalArticle

Huang, C-F, Hung, J-M, Lin, K-H, Sung, C-Y, Lu, Y-J & Lin, Y-H 2007, 'Verruciform Xanthoma of the Oral Mucosa-cases Report', Journal of Dental Sciences, vol. 2, no. 4, pp. 226-229. https://doi.org/10.30086/JDS.200712.0007
Huang, Chlung-Fang ; Hung, Jing-Mrng ; Lin, Kuang-Hsun ; Sung, Cheng-Yue ; Lu, Yr-Jung ; Lin, Yun-Ho. / Verruciform Xanthoma of the Oral Mucosa-cases Report. In: Journal of Dental Sciences. 2007 ; Vol. 2, No. 4. pp. 226-229.
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