Vasoactive alteration and inflammation induced by polycyclic aromatic hydrocarbons and trace metals of vehicle exhaust particles

Hsiao Chi Chuang, Ching Wen Fan, Kuan Yu Chen, Guo Ping Chang-Chien, Chang Chuan Chan

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Exposure to particulate matter (PM) increases the incidence of cardiovascular disease, but the underlying mechanisms remain unclear. To characterise ambient PM collected from a coach station in an urban area, particulate polycyclic aromatic hydrocarbons (PAHs) and trace metals were evaluated, and diagnostic ratios were then used to determine the sources based on the PAHs identified in PM. To elucidate the mechanism of PM-induced vascular toxicology, human coronary artery endothelial cells (HCAECs) were exposed to PM, PM-free supernatant and residual PM, and the associations between PAHs and trace metals, nitric oxide (NO), endothelin-1 (ET-1) and interleukin-6 (IL-6) were investigated. Petrogenic-related particulate emissions, such as vehicle exhaust, accounted for 68.75% and 75.00% of mass in the 0.1-1-μm PM (PM0.1-1) and 0.1) size fractions, respectively. Vehicle exhaust particles (VEPs) caused significant NO suppression and increase in ET-1 and IL-6, whereas residual PM caused an increase in NO, ET-1 and IL-6 compared with the effects of the corresponding supernatants. PAHs in PM, particularly those with 4-6 rings, were associated with NO suppression, and ET-1 and IL-6 were positively correlated with the amount of trace metal compounds. These findings suggest that chemical components affect the regulation of vasoactive function and inflammation.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalToxicology Letters
Volume214
Issue number2
DOIs
Publication statusPublished - Oct 17 2012

Fingerprint

Particulate Matter
Polycyclic Aromatic Hydrocarbons
Metals
Inflammation
Endothelin-1
Interleukin-6
Nitric Oxide
Trace metals
Particulate emissions
Endothelial cells
Toxicology
Blood Vessels
Coronary Vessels
Cardiovascular Diseases
Endothelial Cells

Keywords

  • Endothelin-1
  • Interleukin-6
  • Nitric oxide
  • Polycyclic aromatic hydrocarbons
  • Trace metals

ASJC Scopus subject areas

  • Toxicology

Cite this

Vasoactive alteration and inflammation induced by polycyclic aromatic hydrocarbons and trace metals of vehicle exhaust particles. / Chuang, Hsiao Chi; Fan, Ching Wen; Chen, Kuan Yu; Chang-Chien, Guo Ping; Chan, Chang Chuan.

In: Toxicology Letters, Vol. 214, No. 2, 17.10.2012, p. 131-136.

Research output: Contribution to journalArticle

Chuang, Hsiao Chi ; Fan, Ching Wen ; Chen, Kuan Yu ; Chang-Chien, Guo Ping ; Chan, Chang Chuan. / Vasoactive alteration and inflammation induced by polycyclic aromatic hydrocarbons and trace metals of vehicle exhaust particles. In: Toxicology Letters. 2012 ; Vol. 214, No. 2. pp. 131-136.
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