Vasicine and structurally related quinazolines

Kunal Nepali, Sahil Sharma, Ritu Ojha, Kanaya Lal Dhar

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Natural products are diverse sources of important chemical constituents. Most of the metabolites isolated from them are heterocycles possessing diverse pharmacological actions. Vasicine, a heterocyclic alkaloid possessing a privileged quinazoline nucleus is primarily present in the leaves o the plant Adhatoda vasica nees, family Acanthaceae. Vasicine and structurally related quinazolines have been an area of interest for the researchers all around the world. The present review provides an up to date compilation of the alkaloid vasicine, its biosynthesis, synthesis, biological attributes, design of its synthetic analogues along with structurally related quinazolines.

Original languageEnglish
Pages (from-to)1-15
Number of pages15
JournalMedicinal Chemistry Research
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 2013
Externally publishedYes

Keywords

  • Alkaloid
  • Antitussive
  • Bronchodilator
  • Quinazoline
  • Synthesis

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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