Vascular permeability precedes spontaneous intracerebral hemorrhage in stroke-prone spontaneously hypertensive rats

Jin Moo Lee, Guihua Zhai, Qingwei Liu, Ernesto R. Gonzales, Kejie Yin, Ping Yan, Chung Y. Hsu, Katie D. Vo, Weili Lin

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE - Stroke-prone spontaneous hypertensive rats (SHRsp) fed a high-salt diet develop malignant hypertension, blood-brain barrier breakdown, and spontaneous intracerebral hemorrhage (ICH). The precise spatial and temporal relationship between these events has not been well-delineated. METHODS - Ten SHRsp male rats, fed a high-salt diet, were imaged weekly using MRI, starting at 12 weeks of age. T1-weighted (with and without Gd), T2-weighted, and T2* sequences were acquired. Permeability maps were calculated. RESULTS - Seven SHRsp rats had spontaneous ICH develop before death. Five of the 7 rats had focally increased vascular permeability at the site of the ICH; 3 of these rats had vascular permeability 1 to 2 weeks before spontaneous ICH. CONCLUSIONS - Salt-loaded SHRsp rats have increased vascular permeability up to 2 weeks before ICH, predicting hemorrhage both in space and time. These results suggest that hypertensive ICH is preceded by focal vasculopathy detectable by Gd leak.

Original languageEnglish
Pages (from-to)3289-3291
Number of pages3
JournalStroke
Volume38
Issue number12
DOIs
Publication statusPublished - Dec 2007

Keywords

  • Hypertension
  • Intracerebral hemorrhage
  • MRI

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Vascular permeability precedes spontaneous intracerebral hemorrhage in stroke-prone spontaneously hypertensive rats'. Together they form a unique fingerprint.

  • Cite this

    Lee, J. M., Zhai, G., Liu, Q., Gonzales, E. R., Yin, K., Yan, P., Hsu, C. Y., Vo, K. D., & Lin, W. (2007). Vascular permeability precedes spontaneous intracerebral hemorrhage in stroke-prone spontaneously hypertensive rats. Stroke, 38(12), 3289-3291. https://doi.org/10.1161/STROKEAHA.107.491621