Vascular permeability precedes spontaneous intracerebral hemorrhage in stroke-prone spontaneously hypertensive rats

Jin Moo Lee, Guihua Zhai, Qingwei Liu, Ernesto R. Gonzales, Kejie Yin, Ping Yan, Chung Y. Hsu, Katie D. Vo, Weili Lin

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

BACKGROUND AND PURPOSE - Stroke-prone spontaneous hypertensive rats (SHRsp) fed a high-salt diet develop malignant hypertension, blood-brain barrier breakdown, and spontaneous intracerebral hemorrhage (ICH). The precise spatial and temporal relationship between these events has not been well-delineated. METHODS - Ten SHRsp male rats, fed a high-salt diet, were imaged weekly using MRI, starting at 12 weeks of age. T1-weighted (with and without Gd), T2-weighted, and T2* sequences were acquired. Permeability maps were calculated. RESULTS - Seven SHRsp rats had spontaneous ICH develop before death. Five of the 7 rats had focally increased vascular permeability at the site of the ICH; 3 of these rats had vascular permeability 1 to 2 weeks before spontaneous ICH. CONCLUSIONS - Salt-loaded SHRsp rats have increased vascular permeability up to 2 weeks before ICH, predicting hemorrhage both in space and time. These results suggest that hypertensive ICH is preceded by focal vasculopathy detectable by Gd leak.

Original languageEnglish
Pages (from-to)3289-3291
Number of pages3
JournalStroke
Volume38
Issue number12
DOIs
Publication statusPublished - Dec 2007

Fingerprint

Cerebral Hemorrhage
Capillary Permeability
Inbred SHR Rats
Stroke
Salts
Hypertensive Intracranial Hemorrhage
Malignant Hypertension
Diet
Blood-Brain Barrier
Permeability
Hemorrhage

Keywords

  • Hypertension
  • Intracerebral hemorrhage
  • MRI

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Vascular permeability precedes spontaneous intracerebral hemorrhage in stroke-prone spontaneously hypertensive rats. / Lee, Jin Moo; Zhai, Guihua; Liu, Qingwei; Gonzales, Ernesto R.; Yin, Kejie; Yan, Ping; Hsu, Chung Y.; Vo, Katie D.; Lin, Weili.

In: Stroke, Vol. 38, No. 12, 12.2007, p. 3289-3291.

Research output: Contribution to journalArticle

Lee, JM, Zhai, G, Liu, Q, Gonzales, ER, Yin, K, Yan, P, Hsu, CY, Vo, KD & Lin, W 2007, 'Vascular permeability precedes spontaneous intracerebral hemorrhage in stroke-prone spontaneously hypertensive rats', Stroke, vol. 38, no. 12, pp. 3289-3291. https://doi.org/10.1161/STROKEAHA.107.491621
Lee, Jin Moo ; Zhai, Guihua ; Liu, Qingwei ; Gonzales, Ernesto R. ; Yin, Kejie ; Yan, Ping ; Hsu, Chung Y. ; Vo, Katie D. ; Lin, Weili. / Vascular permeability precedes spontaneous intracerebral hemorrhage in stroke-prone spontaneously hypertensive rats. In: Stroke. 2007 ; Vol. 38, No. 12. pp. 3289-3291.
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AU - Zhai, Guihua

AU - Liu, Qingwei

AU - Gonzales, Ernesto R.

AU - Yin, Kejie

AU - Yan, Ping

AU - Hsu, Chung Y.

AU - Vo, Katie D.

AU - Lin, Weili

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N2 - BACKGROUND AND PURPOSE - Stroke-prone spontaneous hypertensive rats (SHRsp) fed a high-salt diet develop malignant hypertension, blood-brain barrier breakdown, and spontaneous intracerebral hemorrhage (ICH). The precise spatial and temporal relationship between these events has not been well-delineated. METHODS - Ten SHRsp male rats, fed a high-salt diet, were imaged weekly using MRI, starting at 12 weeks of age. T1-weighted (with and without Gd), T2-weighted, and T2* sequences were acquired. Permeability maps were calculated. RESULTS - Seven SHRsp rats had spontaneous ICH develop before death. Five of the 7 rats had focally increased vascular permeability at the site of the ICH; 3 of these rats had vascular permeability 1 to 2 weeks before spontaneous ICH. CONCLUSIONS - Salt-loaded SHRsp rats have increased vascular permeability up to 2 weeks before ICH, predicting hemorrhage both in space and time. These results suggest that hypertensive ICH is preceded by focal vasculopathy detectable by Gd leak.

AB - BACKGROUND AND PURPOSE - Stroke-prone spontaneous hypertensive rats (SHRsp) fed a high-salt diet develop malignant hypertension, blood-brain barrier breakdown, and spontaneous intracerebral hemorrhage (ICH). The precise spatial and temporal relationship between these events has not been well-delineated. METHODS - Ten SHRsp male rats, fed a high-salt diet, were imaged weekly using MRI, starting at 12 weeks of age. T1-weighted (with and without Gd), T2-weighted, and T2* sequences were acquired. Permeability maps were calculated. RESULTS - Seven SHRsp rats had spontaneous ICH develop before death. Five of the 7 rats had focally increased vascular permeability at the site of the ICH; 3 of these rats had vascular permeability 1 to 2 weeks before spontaneous ICH. CONCLUSIONS - Salt-loaded SHRsp rats have increased vascular permeability up to 2 weeks before ICH, predicting hemorrhage both in space and time. These results suggest that hypertensive ICH is preceded by focal vasculopathy detectable by Gd leak.

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