Vascular-metabolic and GABAergic Inhibitory Correlates of Neural Variability Modulation. A Combined fMRI and PET Study

Pengmin Qin, Niall W Duncan, David Yen-Ting Chen, Chi-Jen Chen, Li-Kai Huang, Zirui Huang, Chien-Yuan E Lin, Christine Wiebking, Che-Ming Yang, Georg Northoff, Timothy Lane

Research output: Contribution to journalArticle

Abstract

Neural activity varies continually from moment to moment. Such temporal variability (TV) has been highlighted as a functionally specific brain property playing a fundamental role in cognition. We sought to investigate the mechanisms involved in TV changes between two basic behavioral states, namely having the eyes open (EO) or eyes closed (EC) in vivo in humans. To these ends we acquired BOLD fMRI, ASL, and [18F]-fluoro-deoxyglucose PET in a group of healthy participants (n = 15), along with BOLD fMRI and [18F]-flumazenil PET in a separate group (n = 19). Focusing on an EO- vs EC-sensitive region in the occipital cortex (identified in an independent sample), we show that TV is constrained in the EO condition compared to EC. This reduction is correlated with an increase in energy consumption and with regional GABAAreceptor density. This suggests that the modulation of TV by behavioral state involves an increase in overall neural activity that is related to an increased effect from GABAergic inhibition in addition to any excitatory changes. These findings contribute to our understanding of the mechanisms underlying activity variability in the human brain and its control.

LanguageEnglish
JournalNeuroscience
DOIs
StateE-pub ahead of print - Mar 10 2018

Fingerprint

Blood Vessels
Magnetic Resonance Imaging
Flumazenil
Occipital Lobe
Deoxyglucose
Brain
Cognition
Healthy Volunteers

Cite this

Vascular-metabolic and GABAergic Inhibitory Correlates of Neural Variability Modulation. A Combined fMRI and PET Study. / Qin, Pengmin; Duncan, Niall W; Chen, David Yen-Ting; Chen, Chi-Jen; Huang, Li-Kai; Huang, Zirui; Lin, Chien-Yuan E; Wiebking, Christine; Yang, Che-Ming; Northoff, Georg; Lane, Timothy.

In: Neuroscience, 10.03.2018.

Research output: Contribution to journalArticle

@article{3e26e5536dad424fa58da8891d98363b,
title = "Vascular-metabolic and GABAergic Inhibitory Correlates of Neural Variability Modulation. A Combined fMRI and PET Study",
abstract = "Neural activity varies continually from moment to moment. Such temporal variability (TV) has been highlighted as a functionally specific brain property playing a fundamental role in cognition. We sought to investigate the mechanisms involved in TV changes between two basic behavioral states, namely having the eyes open (EO) or eyes closed (EC) in vivo in humans. To these ends we acquired BOLD fMRI, ASL, and [18F]-fluoro-deoxyglucose PET in a group of healthy participants (n = 15), along with BOLD fMRI and [18F]-flumazenil PET in a separate group (n = 19). Focusing on an EO- vs EC-sensitive region in the occipital cortex (identified in an independent sample), we show that TV is constrained in the EO condition compared to EC. This reduction is correlated with an increase in energy consumption and with regional GABAAreceptor density. This suggests that the modulation of TV by behavioral state involves an increase in overall neural activity that is related to an increased effect from GABAergic inhibition in addition to any excitatory changes. These findings contribute to our understanding of the mechanisms underlying activity variability in the human brain and its control.",
author = "Pengmin Qin and Duncan, {Niall W} and Chen, {David Yen-Ting} and Chi-Jen Chen and Li-Kai Huang and Zirui Huang and Lin, {Chien-Yuan E} and Christine Wiebking and Che-Ming Yang and Georg Northoff and Timothy Lane",
note = "Copyright {\circledC} 2018 IBRO. Published by Elsevier Ltd. All rights reserved.",
year = "2018",
month = "3",
day = "10",
doi = "10.1016/j.neuroscience.2018.02.041",
language = "English",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Vascular-metabolic and GABAergic Inhibitory Correlates of Neural Variability Modulation. A Combined fMRI and PET Study

AU - Qin,Pengmin

AU - Duncan,Niall W

AU - Chen,David Yen-Ting

AU - Chen,Chi-Jen

AU - Huang,Li-Kai

AU - Huang,Zirui

AU - Lin,Chien-Yuan E

AU - Wiebking,Christine

AU - Yang,Che-Ming

AU - Northoff,Georg

AU - Lane,Timothy

N1 - Copyright © 2018 IBRO. Published by Elsevier Ltd. All rights reserved.

PY - 2018/3/10

Y1 - 2018/3/10

N2 - Neural activity varies continually from moment to moment. Such temporal variability (TV) has been highlighted as a functionally specific brain property playing a fundamental role in cognition. We sought to investigate the mechanisms involved in TV changes between two basic behavioral states, namely having the eyes open (EO) or eyes closed (EC) in vivo in humans. To these ends we acquired BOLD fMRI, ASL, and [18F]-fluoro-deoxyglucose PET in a group of healthy participants (n = 15), along with BOLD fMRI and [18F]-flumazenil PET in a separate group (n = 19). Focusing on an EO- vs EC-sensitive region in the occipital cortex (identified in an independent sample), we show that TV is constrained in the EO condition compared to EC. This reduction is correlated with an increase in energy consumption and with regional GABAAreceptor density. This suggests that the modulation of TV by behavioral state involves an increase in overall neural activity that is related to an increased effect from GABAergic inhibition in addition to any excitatory changes. These findings contribute to our understanding of the mechanisms underlying activity variability in the human brain and its control.

AB - Neural activity varies continually from moment to moment. Such temporal variability (TV) has been highlighted as a functionally specific brain property playing a fundamental role in cognition. We sought to investigate the mechanisms involved in TV changes between two basic behavioral states, namely having the eyes open (EO) or eyes closed (EC) in vivo in humans. To these ends we acquired BOLD fMRI, ASL, and [18F]-fluoro-deoxyglucose PET in a group of healthy participants (n = 15), along with BOLD fMRI and [18F]-flumazenil PET in a separate group (n = 19). Focusing on an EO- vs EC-sensitive region in the occipital cortex (identified in an independent sample), we show that TV is constrained in the EO condition compared to EC. This reduction is correlated with an increase in energy consumption and with regional GABAAreceptor density. This suggests that the modulation of TV by behavioral state involves an increase in overall neural activity that is related to an increased effect from GABAergic inhibition in addition to any excitatory changes. These findings contribute to our understanding of the mechanisms underlying activity variability in the human brain and its control.

U2 - 10.1016/j.neuroscience.2018.02.041

DO - 10.1016/j.neuroscience.2018.02.041

M3 - Article

JO - Neuroscience

T2 - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -