Vascular endothelial growth factor is associated with blood brain barrier dysfunction in eosinophilic meningitis caused by Angiostrongylus cantonensis infection

Hung Chin Tsai, Yung-Ching Liu, Susan Shin Jung Lee, Eng Rin Chen, Chuan Min Yen

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12 Citations (Scopus)

Abstract

Vascular endothelial growth factor (VEGF) is a potent vascular permeability factor and a mediator of brain edema. To assess the role of vascular endothelial growth factor in eosinophilic meningitis, vascular endothelial growth factor was measured in the cerebrospinal fluid (CSF) and blood of 9 patients with eosinophilic meningitis in a cohort study. VEGFCSF was detected in 8 (90%) of 9 eosinophilic meningitis patients (range, 45-2190 pg/mL) at presentation. The mean VEGFCSF at presentation, 1 week, and 2 weeks after admission was 568 pg/mL, 751 pg/mL, and 1031 pg/mL, respectively. There was an association between VEGFCSF, CSF protein, white cell count, and eosinophil counts. The VEGFSERUM fluctuated during the 6-month follow-up period. These results indicate that vascular endothelial growth factor may be associated with blood-brain barrier disruption in patients with eosinophilic meningitis.

Original languageEnglish
Pages (from-to)592-595
Number of pages4
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume76
Issue number3
Publication statusPublished - Mar 2007
Externally publishedYes

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ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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