Value of serum and follicular fluid cytokine profile in the prediction of moderate to severe ovarian hyperstimulation syndrome

Chin Der Chen, Hsin Fu Chen, Hsin Fen Lu, Shee Uan Chen, Hong Nerng Ho, Yu Shih Yang

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The aim of this study was to examine the role of serum and follicular fluid pro-inflammatory cytokines and vascular endothelial growth factor (VEGF) in the prediction of ovarian hyperstimulation syndrome (OHSS). A total of 156 consecutive women undergoing in-vitro fertilization were recruited. The study group comprised 12 women who subsequently developed moderate (n = 7) or severe (n = 5) OHSS. The two control groups were comprised of a randomized selection of 12 high-risk and 12 low-risk women in whom OHSS did not develop. Serum was collected on days of human chorionic gonadotrophin, oocyte retrieval, and embryo transfer. Serum and follicular fluid concentrations of interleukin (IL)-6, IL-8, tumour necrosis factor-α (TNF-α), and VEGF were measured. Follicular fluid IL-6 concentrations at the time of oocyte retrieval and serum IL-8 concentrations at the time of embryo transfer were significantly higher in the OHSS compared to the two control groups (P = 0.026 and P = 0.017 respectively). Serum concentrations of TNF-α and VEGF showed no statistically significant difference between the OHSS group and the controls at any studied time point. This study suggests that follicular fluid IL-6 concentrations at the time of oocyte retrieval and serum IL-8 concentrations on the day of embryo transfer may serve as early predictors for this syndrome.

Original languageEnglish
Pages (from-to)1037-1042
Number of pages6
JournalHuman Reproduction
Volume15
Issue number5
Publication statusPublished - Jan 1 2000
Externally publishedYes

Fingerprint

Ovarian Hyperstimulation Syndrome
Follicular Fluid
Cytokines
Oocyte Retrieval
Embryo Transfer
Serum
Interleukin-8
Vascular Endothelial Growth Factor A
Interleukin-6
Control Groups
Tumor Necrosis Factor-alpha
Chorionic Gonadotropin
Fertilization in Vitro

Keywords

  • Cytokine
  • Follicular fluid
  • Ovarian hyperstimulation syndrome
  • Prediction
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Value of serum and follicular fluid cytokine profile in the prediction of moderate to severe ovarian hyperstimulation syndrome. / Chen, Chin Der; Chen, Hsin Fu; Lu, Hsin Fen; Chen, Shee Uan; Ho, Hong Nerng; Yang, Yu Shih.

In: Human Reproduction, Vol. 15, No. 5, 01.01.2000, p. 1037-1042.

Research output: Contribution to journalArticle

Chen, Chin Der ; Chen, Hsin Fu ; Lu, Hsin Fen ; Chen, Shee Uan ; Ho, Hong Nerng ; Yang, Yu Shih. / Value of serum and follicular fluid cytokine profile in the prediction of moderate to severe ovarian hyperstimulation syndrome. In: Human Reproduction. 2000 ; Vol. 15, No. 5. pp. 1037-1042.
@article{0a0d221378a34360a0e75933f637b020,
title = "Value of serum and follicular fluid cytokine profile in the prediction of moderate to severe ovarian hyperstimulation syndrome",
abstract = "The aim of this study was to examine the role of serum and follicular fluid pro-inflammatory cytokines and vascular endothelial growth factor (VEGF) in the prediction of ovarian hyperstimulation syndrome (OHSS). A total of 156 consecutive women undergoing in-vitro fertilization were recruited. The study group comprised 12 women who subsequently developed moderate (n = 7) or severe (n = 5) OHSS. The two control groups were comprised of a randomized selection of 12 high-risk and 12 low-risk women in whom OHSS did not develop. Serum was collected on days of human chorionic gonadotrophin, oocyte retrieval, and embryo transfer. Serum and follicular fluid concentrations of interleukin (IL)-6, IL-8, tumour necrosis factor-α (TNF-α), and VEGF were measured. Follicular fluid IL-6 concentrations at the time of oocyte retrieval and serum IL-8 concentrations at the time of embryo transfer were significantly higher in the OHSS compared to the two control groups (P = 0.026 and P = 0.017 respectively). Serum concentrations of TNF-α and VEGF showed no statistically significant difference between the OHSS group and the controls at any studied time point. This study suggests that follicular fluid IL-6 concentrations at the time of oocyte retrieval and serum IL-8 concentrations on the day of embryo transfer may serve as early predictors for this syndrome.",
keywords = "Cytokine, Follicular fluid, Ovarian hyperstimulation syndrome, Prediction, Vascular endothelial growth factor",
author = "Chen, {Chin Der} and Chen, {Hsin Fu} and Lu, {Hsin Fen} and Chen, {Shee Uan} and Ho, {Hong Nerng} and Yang, {Yu Shih}",
year = "2000",
month = "1",
day = "1",
language = "English",
volume = "15",
pages = "1037--1042",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Value of serum and follicular fluid cytokine profile in the prediction of moderate to severe ovarian hyperstimulation syndrome

AU - Chen, Chin Der

AU - Chen, Hsin Fu

AU - Lu, Hsin Fen

AU - Chen, Shee Uan

AU - Ho, Hong Nerng

AU - Yang, Yu Shih

PY - 2000/1/1

Y1 - 2000/1/1

N2 - The aim of this study was to examine the role of serum and follicular fluid pro-inflammatory cytokines and vascular endothelial growth factor (VEGF) in the prediction of ovarian hyperstimulation syndrome (OHSS). A total of 156 consecutive women undergoing in-vitro fertilization were recruited. The study group comprised 12 women who subsequently developed moderate (n = 7) or severe (n = 5) OHSS. The two control groups were comprised of a randomized selection of 12 high-risk and 12 low-risk women in whom OHSS did not develop. Serum was collected on days of human chorionic gonadotrophin, oocyte retrieval, and embryo transfer. Serum and follicular fluid concentrations of interleukin (IL)-6, IL-8, tumour necrosis factor-α (TNF-α), and VEGF were measured. Follicular fluid IL-6 concentrations at the time of oocyte retrieval and serum IL-8 concentrations at the time of embryo transfer were significantly higher in the OHSS compared to the two control groups (P = 0.026 and P = 0.017 respectively). Serum concentrations of TNF-α and VEGF showed no statistically significant difference between the OHSS group and the controls at any studied time point. This study suggests that follicular fluid IL-6 concentrations at the time of oocyte retrieval and serum IL-8 concentrations on the day of embryo transfer may serve as early predictors for this syndrome.

AB - The aim of this study was to examine the role of serum and follicular fluid pro-inflammatory cytokines and vascular endothelial growth factor (VEGF) in the prediction of ovarian hyperstimulation syndrome (OHSS). A total of 156 consecutive women undergoing in-vitro fertilization were recruited. The study group comprised 12 women who subsequently developed moderate (n = 7) or severe (n = 5) OHSS. The two control groups were comprised of a randomized selection of 12 high-risk and 12 low-risk women in whom OHSS did not develop. Serum was collected on days of human chorionic gonadotrophin, oocyte retrieval, and embryo transfer. Serum and follicular fluid concentrations of interleukin (IL)-6, IL-8, tumour necrosis factor-α (TNF-α), and VEGF were measured. Follicular fluid IL-6 concentrations at the time of oocyte retrieval and serum IL-8 concentrations at the time of embryo transfer were significantly higher in the OHSS compared to the two control groups (P = 0.026 and P = 0.017 respectively). Serum concentrations of TNF-α and VEGF showed no statistically significant difference between the OHSS group and the controls at any studied time point. This study suggests that follicular fluid IL-6 concentrations at the time of oocyte retrieval and serum IL-8 concentrations on the day of embryo transfer may serve as early predictors for this syndrome.

KW - Cytokine

KW - Follicular fluid

KW - Ovarian hyperstimulation syndrome

KW - Prediction

KW - Vascular endothelial growth factor

UR - http://www.scopus.com/inward/record.url?scp=0034098043&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034098043&partnerID=8YFLogxK

M3 - Article

C2 - 10783347

AN - SCOPUS:0034098043

VL - 15

SP - 1037

EP - 1042

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 5

ER -