Validity of symptoms and radiographic features in predicting positive acid-fast bacilli smears in adolescents with tuberculosis

Kin Sun Wong, Y. C. Huang, S. H. Lai, C. Y. Chiu, Y. C. Huang, T. Y. Lin

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

SETTING: A cohort of 78 adolescents was selected for evaluation with culture or histologically proven pulmonary tuberculosis (PTB) from a tertiary paediatric facility in northern Taiwan. OBJECTIVE: To assess the validity of clinical features and radiographic findings for predicting positive smears of acid-fast bacilli (AFB) in adolescents with PTB. DESIGN: A retrospective descriptive study of adolescents with a confirmed diagnosis of PTB. Clinical symptoms and chest radiographs were assessed. Univariate analysis identified risk factors suggestive of a positive AFB smear, and the adjusted odds ratio (aOR) for these features was calculated using logistic regression. RESULTS: Patients who were AFB smear-positive and those who were smear-negative differed significantly on univariate analysis (P < 0.05) with respect to chronic cough, haemoptysis, multilobar or superior segment of lower lobe involvement, cavitations or presence of pleural effusions. Logistic regression analysis revealed that risk factors of positive smear in adolescents with PTB were chronic cough >4 weeks (aOR 13.8, 95%CI 2.3-83.1), lower lobe involvement (aOR 12.6, 95%CI 1.2-134.8) and pulmonary cavitations (aOR 7.7, 95%CI 1.0-57.7). CONCLUSIONS: For adolescents with PTB, those suffering from chronic cough for >4 weeks, with involvement of the superior segment of the lower lobe or with cavitary lesions, have a greater likelihood of transmitting tuberculosis due to smear positivity.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalInternational Journal of Tuberculosis and Lung Disease
Volume14
Issue number2
Publication statusPublished - Feb 2010
Externally publishedYes

Fingerprint

Pulmonary Tuberculosis
Bacillus
Tuberculosis
Odds Ratio
Acids
Taiwan
Cough
Thorax
Retrospective Studies
Logistic Models
Pediatrics
Lung

Keywords

  • ; tuberculosis
  • Adolescent
  • Cavitations
  • Chronic cough
  • Pulmonary
  • Smear AFB

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Validity of symptoms and radiographic features in predicting positive acid-fast bacilli smears in adolescents with tuberculosis. / Wong, Kin Sun; Huang, Y. C.; Lai, S. H.; Chiu, C. Y.; Huang, Y. C.; Lin, T. Y.

In: International Journal of Tuberculosis and Lung Disease, Vol. 14, No. 2, 02.2010, p. 155-159.

Research output: Contribution to journalArticle

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