Validation of the jugular venous reflux animal model by three-dimensional time-of-flight MRA with a clinical scanner

Charng Chyi Shieh, Han Hwa Hu, Shun Tai Yang, Tsong Hai Lee, Jee Ching Hsu, Yau Yau Wai, Ho Fai Wong, Chih Ping Chung

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background and Purpose: A rat model of jugular venous reflux (JVR) is widely used in studies of cerebral arteriovenous fistula, cerebral venous hypertension and chronic cerebral hypoperfusion. However, methods to validate the effectiveness of the operation are needed. Methods: We performed neck 3-dimensional time-of-flight magnetic resonance angiography (MRA) with a clinical scanner in a rat model of JVR before and after the operation. High-resolution arterial angiography of the rat neck was acquired with maximum intensity projection. Results: In the JVR model, the success of the operation was validated by enhanced venous structures on MRA. The angiogram also provided information on the height of JVR and the status of other neck vessels. Conclusions: In conclusion, neck 3-dimensional time-of-flight MRA is a useful noninvasive method for monitoring the blood flow in multiple cerebral vessels in this animal model. It also revealed the height of JVR, collateral development and changes in vessels over time in longitudinal studies. This information should be considered in the evaluation of the animal model.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalCerebrovascular Diseases
Volume30
Issue number2
DOIs
Publication statusPublished - Jul 2010

Fingerprint

Magnetic Resonance Angiography
Neck
Animal Models
Angiography
Arteriovenous Fistula
Longitudinal Studies
Hypertension

Keywords

  • Animal models
  • Extracranial arteries
  • Jugular venous reflux
  • Magnetic resonance angiography
  • Vascular neurosurgery

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Validation of the jugular venous reflux animal model by three-dimensional time-of-flight MRA with a clinical scanner. / Shieh, Charng Chyi; Hu, Han Hwa; Yang, Shun Tai; Lee, Tsong Hai; Hsu, Jee Ching; Wai, Yau Yau; Wong, Ho Fai; Chung, Chih Ping.

In: Cerebrovascular Diseases, Vol. 30, No. 2, 07.2010, p. 167-171.

Research output: Contribution to journalArticle

Shieh, Charng Chyi ; Hu, Han Hwa ; Yang, Shun Tai ; Lee, Tsong Hai ; Hsu, Jee Ching ; Wai, Yau Yau ; Wong, Ho Fai ; Chung, Chih Ping. / Validation of the jugular venous reflux animal model by three-dimensional time-of-flight MRA with a clinical scanner. In: Cerebrovascular Diseases. 2010 ; Vol. 30, No. 2. pp. 167-171.
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AU - Hsu, Jee Ching

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AU - Wong, Ho Fai

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