Vaginal primary malignant melanoma of a Chinese woman: An exceptionally rare yet lethal case report and literature review

Research output: Contribution to journalReview article

Abstract

Vaginal primary malignant melanoma is an exceptionally rare, especially in Taiwan, yet lethal disease, with a five-year overall survival rate of only 18%. Recent elucidation of alternating pathogenesis and refinement of diagnostic methodologies are vital for future management standardization. The authors describe a case of a 58-year-old postmenopausal Chinese woman with vaginal malignant melanoma, with vaginal spotting and vulvar itching as initial presentation. After immunohistochemical staining of biopsy specimen had shown positive of S-100 and HMB-45, and total vaginectomy with bilateral inguinal lymphadenectomy was performed. The patient remains free of disease six months after discharge. In conclusion, vaginal primary malignant melanoma with initial presentation mimicking vaginitis and symptomatic menopausal state could cause diagnostic confusion, especially at postmenopausal woman. By understanding clinical presentation, pathogenesis, differential diagnosis, and treatment options of vaginal primary malignant melanoma, effective diagnosis could be possible.

Original languageEnglish
Pages (from-to)327-330
Number of pages4
JournalEuropean Journal of Gynaecological Oncology
Volume39
Issue number2
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

Melanoma
Vaginitis
Metrorrhagia
Groin
Pruritus
Lymph Node Excision
Taiwan
Differential Diagnosis
Survival Rate
Staining and Labeling
Biopsy
Therapeutics

Keywords

  • BRAF mutation
  • HMB-45
  • S-100
  • Taiwanese
  • Vaginal melanoma
  • Vaginectomy

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

Cite this

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title = "Vaginal primary malignant melanoma of a Chinese woman: An exceptionally rare yet lethal case report and literature review",
abstract = "Vaginal primary malignant melanoma is an exceptionally rare, especially in Taiwan, yet lethal disease, with a five-year overall survival rate of only 18{\%}. Recent elucidation of alternating pathogenesis and refinement of diagnostic methodologies are vital for future management standardization. The authors describe a case of a 58-year-old postmenopausal Chinese woman with vaginal malignant melanoma, with vaginal spotting and vulvar itching as initial presentation. After immunohistochemical staining of biopsy specimen had shown positive of S-100 and HMB-45, and total vaginectomy with bilateral inguinal lymphadenectomy was performed. The patient remains free of disease six months after discharge. In conclusion, vaginal primary malignant melanoma with initial presentation mimicking vaginitis and symptomatic menopausal state could cause diagnostic confusion, especially at postmenopausal woman. By understanding clinical presentation, pathogenesis, differential diagnosis, and treatment options of vaginal primary malignant melanoma, effective diagnosis could be possible.",
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T2 - An exceptionally rare yet lethal case report and literature review

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N2 - Vaginal primary malignant melanoma is an exceptionally rare, especially in Taiwan, yet lethal disease, with a five-year overall survival rate of only 18%. Recent elucidation of alternating pathogenesis and refinement of diagnostic methodologies are vital for future management standardization. The authors describe a case of a 58-year-old postmenopausal Chinese woman with vaginal malignant melanoma, with vaginal spotting and vulvar itching as initial presentation. After immunohistochemical staining of biopsy specimen had shown positive of S-100 and HMB-45, and total vaginectomy with bilateral inguinal lymphadenectomy was performed. The patient remains free of disease six months after discharge. In conclusion, vaginal primary malignant melanoma with initial presentation mimicking vaginitis and symptomatic menopausal state could cause diagnostic confusion, especially at postmenopausal woman. By understanding clinical presentation, pathogenesis, differential diagnosis, and treatment options of vaginal primary malignant melanoma, effective diagnosis could be possible.

AB - Vaginal primary malignant melanoma is an exceptionally rare, especially in Taiwan, yet lethal disease, with a five-year overall survival rate of only 18%. Recent elucidation of alternating pathogenesis and refinement of diagnostic methodologies are vital for future management standardization. The authors describe a case of a 58-year-old postmenopausal Chinese woman with vaginal malignant melanoma, with vaginal spotting and vulvar itching as initial presentation. After immunohistochemical staining of biopsy specimen had shown positive of S-100 and HMB-45, and total vaginectomy with bilateral inguinal lymphadenectomy was performed. The patient remains free of disease six months after discharge. In conclusion, vaginal primary malignant melanoma with initial presentation mimicking vaginitis and symptomatic menopausal state could cause diagnostic confusion, especially at postmenopausal woman. By understanding clinical presentation, pathogenesis, differential diagnosis, and treatment options of vaginal primary malignant melanoma, effective diagnosis could be possible.

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