Vagal stimulation induces increased pulmonary vascular permeability in guinea pig

Shufang Liu, Han Pin Kuo, Mary N. Sheppard, Peter J. Barnes, Timothy W. Evans

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The effects of vagal stimulation on pulmonary vascular permeability were studied in guinea pigs in vivo using 125-labeled albumin as a marker of plasma extravasation. Bilateral vagus nerve stimulation (NS) significantly increased the plasma leakage index in both parenchyma and tracheobronchial tissues. The NS-induced plasma leakage in the parenchyma was unaffected by the α-adrenoceptor antagonist phentolamine, the muscarinic receptor antagonist atropine, the ganglionic blocker hexamethonium or pretreatment with 6-hydroxydopamine or capsaicin, but it was significantly potentiated by the β-adrenoceptor antagonist propranolol. NS-induced tracheobronchial vascular leakage was markedly inhibited by pretreatment with atropine, hexamethonium, or capsaicin, although it was unaffected by pretreatment with phentolamine, propranolol, or 6-hydroxydopamine. By itself, N(G)-nitro L- arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthase, had no effect on pulmonary vascular leakage, but it significantly enhanced the NS-induced plasma leakage to parenchyma in a dose-related and L-arginine- reversible manner. Elevation of blood pressure to a similar extent as that induced by L-NAME by a phenylephrine infusion had no significant effect on the increased plasma leakage induced by NS. These results suggest that vagal stimulation increases plasma extravasation in lung parenchyma through the release of unidentified transmitter(s) in a process that is modulated by endogenous NO and catecholamines (via activation of β-adrenoceptors), and that different mechanisms are involved in the vagally induced plasma extravasation in the pulmonary and tracheobronchial vascular beds.

Original languageEnglish
Pages (from-to)744-750
Number of pages7
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume149
Issue number3 I
Publication statusPublished - Mar 1 1994
Externally publishedYes

Fingerprint

Capillary Permeability
Guinea Pigs
Lung
NG-Nitroarginine Methyl Ester
Adrenergic Receptors
Blood Vessels
Hexamethonium
Phentolamine
Oxidopamine
Capsaicin
Atropine
Propranolol
Ganglionic Blockers
Vagus Nerve Stimulation
Muscarinic Antagonists
Phenylephrine
Muscarinic Receptors
Nitric Oxide Synthase
Catecholamines
Arginine

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Vagal stimulation induces increased pulmonary vascular permeability in guinea pig. / Liu, Shufang; Kuo, Han Pin; Sheppard, Mary N.; Barnes, Peter J.; Evans, Timothy W.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 149, No. 3 I, 01.03.1994, p. 744-750.

Research output: Contribution to journalArticle

Liu, Shufang ; Kuo, Han Pin ; Sheppard, Mary N. ; Barnes, Peter J. ; Evans, Timothy W. / Vagal stimulation induces increased pulmonary vascular permeability in guinea pig. In: American Journal of Respiratory and Critical Care Medicine. 1994 ; Vol. 149, No. 3 I. pp. 744-750.
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