Uterine sarcoma Part I—Uterine leiomyosarcoma: The Topic Advisory Group systematic review

Kuo Chang Wen, Huann Cheng Horng, Peng Hui Wang, Yi Jen Chen, Ming Shyen Yen, Heung Tat Ng, Yen Hou Chang, Yi Chang, Hsiang Tai Chao, Kuan Chong Chao, Chi Mu Chuang, Chi Hong Ho, Chen Yu Huang, Zhi Chen Hung, Ling Yu Jiang, Hei Yu Lau, Hsin Yang Li, Chi Yao Lin, Chia Hao Liu, Pi Lin SunNae Fang Twu, Hua Hsi Wu, Hann Chin Yu, Fong Yuan Ju, Chih Ping Tsai, Wen Hsun Chang, Yen Mei Hsu, Na Rong Lee, Chih Yao Chen, Ting Chen Chang, Wen Chun Chang, Chii Hou Chen, Ruey Jian Chen, Song Nan Chow, Yih Ron Lien, Bor Ching Sheu, Pao Ling Torng, Men Luh Yen, Wen Ling Lee, Kuan Chin Wang, Chih Long Chang, Chih Ping Chen, Jen Ruei Chen, Tze Chien Chen, Jian Pei Huang, Ming Chao Huang, Yeou Lih Wang, Cheng Chang Chang, Jah Yao Liu, Her Young Su, Yu Chi Wang, Mu Hsien Yu, Lee Wen Huang, Kok Min Seow, Tsung Hsuan Lai, Fa Kung Lee, Ching Hui Chen, Ben Shian Huang, Sheng Mou Hsiao, Hsu Dong Sun, Wen Yih Wu, Sen Wen Teng, Kuo Hu Chen, Jeng Hsiu Hung, Hung Cheng Lai, Chiou Chung Yuan, Ching Hung Hsieh, Chin Jung Wang, Shing Jyh Chang, Man Jung Hung, Shih Tien Hsu, Yu Min Ke, Chien Hsing Lu, Lou Sun, Wei Chun Chang, Yao Ching Hung, Wu Chou Lin, Po Hui Wang, Tze Ho Chen, Yiu Tai Li, Meng Hsing Wu, Kuo Feng Huang, Hung Chun Fu, San Nung Chen, An Jen Chiang, Ju Yueh Li, Li Te Lin, Hsiao Wen Tsai, Kuan Hao Tsui

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Uterine sarcomas account for 3–7% of all uterine cancers. Because of their rarity, unknown etiology, and highly divergent genetic aberration, there is a lack of consensus on risk factors for occurrence and predictive poor outcomes as well as optimal therapeutic choices. Tumor types according to the World Health Organization classification include leiomyosarcoma, endometrial stroma sarcoma, and undifferentiated sarcoma. Staging is done using the 2014 Federation International Gynecology and Obstetrics and 2010 American Joint Committee on Cancer tumor, lymph node, and metastases systems. Tumor grade can be classified based on the French Federation of Cancer Centers Sarcoma Group system or the Broder's system that incorporates tumor differentiation, mitotic count, and tumor necrosis. This review is a series of articles discussing uterine sarcoma, and this is Part I, which focuses on one of the subtypes of uterine sarcomas—uterine leiomyosarcoma. The clinical characteristics, diagnosis, outcome, and recent advances are summarized in this article.

Original languageEnglish
Pages (from-to)463-471
Number of pages9
JournalTaiwanese Journal of Obstetrics and Gynecology
Volume55
Issue number4
DOIs
Publication statusPublished - Aug 1 2016

Fingerprint

Leiomyosarcoma
Sarcoma
Neoplasms
Sarcoma 37
Uterine Neoplasms
Gynecology
Obstetrics
Necrosis
Lymph Nodes
Neoplasm Metastasis

Keywords

  • diagnosis
  • leiomyosarcoma
  • treatment
  • uterine sarcoma
  • uterus

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Uterine sarcoma Part I—Uterine leiomyosarcoma : The Topic Advisory Group systematic review. / Wen, Kuo Chang; Horng, Huann Cheng; Wang, Peng Hui; Chen, Yi Jen; Yen, Ming Shyen; Ng, Heung Tat; Chang, Yen Hou; Chang, Yi; Chao, Hsiang Tai; Chao, Kuan Chong; Chuang, Chi Mu; Ho, Chi Hong; Huang, Chen Yu; Hung, Zhi Chen; Jiang, Ling Yu; Lau, Hei Yu; Li, Hsin Yang; Lin, Chi Yao; Liu, Chia Hao; Sun, Pi Lin; Twu, Nae Fang; Wu, Hua Hsi; Yu, Hann Chin; Ju, Fong Yuan; Tsai, Chih Ping; Chang, Wen Hsun; Hsu, Yen Mei; Lee, Na Rong; Chen, Chih Yao; Chang, Ting Chen; Chang, Wen Chun; Chen, Chii Hou; Chen, Ruey Jian; Chow, Song Nan; Lien, Yih Ron; Sheu, Bor Ching; Torng, Pao Ling; Yen, Men Luh; Lee, Wen Ling; Wang, Kuan Chin; Chang, Chih Long; Chen, Chih Ping; Chen, Jen Ruei; Chen, Tze Chien; Huang, Jian Pei; Huang, Ming Chao; Wang, Yeou Lih; Chang, Cheng Chang; Liu, Jah Yao; Su, Her Young; Wang, Yu Chi; Yu, Mu Hsien; Huang, Lee Wen; Seow, Kok Min; Lai, Tsung Hsuan; Lee, Fa Kung; Chen, Ching Hui; Huang, Ben Shian; Hsiao, Sheng Mou; Sun, Hsu Dong; Wu, Wen Yih; Teng, Sen Wen; Chen, Kuo Hu; Hung, Jeng Hsiu; Lai, Hung Cheng; Yuan, Chiou Chung; Hsieh, Ching Hung; Wang, Chin Jung; Chang, Shing Jyh; Hung, Man Jung; Hsu, Shih Tien; Ke, Yu Min; Lu, Chien Hsing; Sun, Lou; Chang, Wei Chun; Hung, Yao Ching; Lin, Wu Chou; Wang, Po Hui; Chen, Tze Ho; Li, Yiu Tai; Wu, Meng Hsing; Huang, Kuo Feng; Fu, Hung Chun; Chen, San Nung; Chiang, An Jen; Li, Ju Yueh; Lin, Li Te; Tsai, Hsiao Wen; Tsui, Kuan Hao.

In: Taiwanese Journal of Obstetrics and Gynecology, Vol. 55, No. 4, 01.08.2016, p. 463-471.

Research output: Contribution to journalReview article

Wen, KC, Horng, HC, Wang, PH, Chen, YJ, Yen, MS, Ng, HT, Chang, YH, Chang, Y, Chao, HT, Chao, KC, Chuang, CM, Ho, CH, Huang, CY, Hung, ZC, Jiang, LY, Lau, HY, Li, HY, Lin, CY, Liu, CH, Sun, PL, Twu, NF, Wu, HH, Yu, HC, Ju, FY, Tsai, CP, Chang, WH, Hsu, YM, Lee, NR, Chen, CY, Chang, TC, Chang, WC, Chen, CH, Chen, RJ, Chow, SN, Lien, YR, Sheu, BC, Torng, PL, Yen, ML, Lee, WL, Wang, KC, Chang, CL, Chen, CP, Chen, JR, Chen, TC, Huang, JP, Huang, MC, Wang, YL, Chang, CC, Liu, JY, Su, HY, Wang, YC, Yu, MH, Huang, LW, Seow, KM, Lai, TH, Lee, FK, Chen, CH, Huang, BS, Hsiao, SM, Sun, HD, Wu, WY, Teng, SW, Chen, KH, Hung, JH, Lai, HC, Yuan, CC, Hsieh, CH, Wang, CJ, Chang, SJ, Hung, MJ, Hsu, ST, Ke, YM, Lu, CH, Sun, L, Chang, WC, Hung, YC, Lin, WC, Wang, PH, Chen, TH, Li, YT, Wu, MH, Huang, KF, Fu, HC, Chen, SN, Chiang, AJ, Li, JY, Lin, LT, Tsai, HW & Tsui, KH 2016, 'Uterine sarcoma Part I—Uterine leiomyosarcoma: The Topic Advisory Group systematic review', Taiwanese Journal of Obstetrics and Gynecology, vol. 55, no. 4, pp. 463-471. https://doi.org/10.1016/j.tjog.2016.04.033
Wen, Kuo Chang ; Horng, Huann Cheng ; Wang, Peng Hui ; Chen, Yi Jen ; Yen, Ming Shyen ; Ng, Heung Tat ; Chang, Yen Hou ; Chang, Yi ; Chao, Hsiang Tai ; Chao, Kuan Chong ; Chuang, Chi Mu ; Ho, Chi Hong ; Huang, Chen Yu ; Hung, Zhi Chen ; Jiang, Ling Yu ; Lau, Hei Yu ; Li, Hsin Yang ; Lin, Chi Yao ; Liu, Chia Hao ; Sun, Pi Lin ; Twu, Nae Fang ; Wu, Hua Hsi ; Yu, Hann Chin ; Ju, Fong Yuan ; Tsai, Chih Ping ; Chang, Wen Hsun ; Hsu, Yen Mei ; Lee, Na Rong ; Chen, Chih Yao ; Chang, Ting Chen ; Chang, Wen Chun ; Chen, Chii Hou ; Chen, Ruey Jian ; Chow, Song Nan ; Lien, Yih Ron ; Sheu, Bor Ching ; Torng, Pao Ling ; Yen, Men Luh ; Lee, Wen Ling ; Wang, Kuan Chin ; Chang, Chih Long ; Chen, Chih Ping ; Chen, Jen Ruei ; Chen, Tze Chien ; Huang, Jian Pei ; Huang, Ming Chao ; Wang, Yeou Lih ; Chang, Cheng Chang ; Liu, Jah Yao ; Su, Her Young ; Wang, Yu Chi ; Yu, Mu Hsien ; Huang, Lee Wen ; Seow, Kok Min ; Lai, Tsung Hsuan ; Lee, Fa Kung ; Chen, Ching Hui ; Huang, Ben Shian ; Hsiao, Sheng Mou ; Sun, Hsu Dong ; Wu, Wen Yih ; Teng, Sen Wen ; Chen, Kuo Hu ; Hung, Jeng Hsiu ; Lai, Hung Cheng ; Yuan, Chiou Chung ; Hsieh, Ching Hung ; Wang, Chin Jung ; Chang, Shing Jyh ; Hung, Man Jung ; Hsu, Shih Tien ; Ke, Yu Min ; Lu, Chien Hsing ; Sun, Lou ; Chang, Wei Chun ; Hung, Yao Ching ; Lin, Wu Chou ; Wang, Po Hui ; Chen, Tze Ho ; Li, Yiu Tai ; Wu, Meng Hsing ; Huang, Kuo Feng ; Fu, Hung Chun ; Chen, San Nung ; Chiang, An Jen ; Li, Ju Yueh ; Lin, Li Te ; Tsai, Hsiao Wen ; Tsui, Kuan Hao. / Uterine sarcoma Part I—Uterine leiomyosarcoma : The Topic Advisory Group systematic review. In: Taiwanese Journal of Obstetrics and Gynecology. 2016 ; Vol. 55, No. 4. pp. 463-471.
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AU - Wen, Kuo Chang

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AU - Yen, Ming Shyen

AU - Ng, Heung Tat

AU - Chang, Yen Hou

AU - Chang, Yi

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AU - Chao, Kuan Chong

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AU - Ho, Chi Hong

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AU - Lau, Hei Yu

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AU - Sun, Pi Lin

AU - Twu, Nae Fang

AU - Wu, Hua Hsi

AU - Yu, Hann Chin

AU - Ju, Fong Yuan

AU - Tsai, Chih Ping

AU - Chang, Wen Hsun

AU - Hsu, Yen Mei

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AU - Chen, Chih Yao

AU - Chang, Ting Chen

AU - Chang, Wen Chun

AU - Chen, Chii Hou

AU - Chen, Ruey Jian

AU - Chow, Song Nan

AU - Lien, Yih Ron

AU - Sheu, Bor Ching

AU - Torng, Pao Ling

AU - Yen, Men Luh

AU - Lee, Wen Ling

AU - Wang, Kuan Chin

AU - Chang, Chih Long

AU - Chen, Chih Ping

AU - Chen, Jen Ruei

AU - Chen, Tze Chien

AU - Huang, Jian Pei

AU - Huang, Ming Chao

AU - Wang, Yeou Lih

AU - Chang, Cheng Chang

AU - Liu, Jah Yao

AU - Su, Her Young

AU - Wang, Yu Chi

AU - Yu, Mu Hsien

AU - Huang, Lee Wen

AU - Seow, Kok Min

AU - Lai, Tsung Hsuan

AU - Lee, Fa Kung

AU - Chen, Ching Hui

AU - Huang, Ben Shian

AU - Hsiao, Sheng Mou

AU - Sun, Hsu Dong

AU - Wu, Wen Yih

AU - Teng, Sen Wen

AU - Chen, Kuo Hu

AU - Hung, Jeng Hsiu

AU - Lai, Hung Cheng

AU - Yuan, Chiou Chung

AU - Hsieh, Ching Hung

AU - Wang, Chin Jung

AU - Chang, Shing Jyh

AU - Hung, Man Jung

AU - Hsu, Shih Tien

AU - Ke, Yu Min

AU - Lu, Chien Hsing

AU - Sun, Lou

AU - Chang, Wei Chun

AU - Hung, Yao Ching

AU - Lin, Wu Chou

AU - Wang, Po Hui

AU - Chen, Tze Ho

AU - Li, Yiu Tai

AU - Wu, Meng Hsing

AU - Huang, Kuo Feng

AU - Fu, Hung Chun

AU - Chen, San Nung

AU - Chiang, An Jen

AU - Li, Ju Yueh

AU - Lin, Li Te

AU - Tsai, Hsiao Wen

AU - Tsui, Kuan Hao

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N2 - Uterine sarcomas account for 3–7% of all uterine cancers. Because of their rarity, unknown etiology, and highly divergent genetic aberration, there is a lack of consensus on risk factors for occurrence and predictive poor outcomes as well as optimal therapeutic choices. Tumor types according to the World Health Organization classification include leiomyosarcoma, endometrial stroma sarcoma, and undifferentiated sarcoma. Staging is done using the 2014 Federation International Gynecology and Obstetrics and 2010 American Joint Committee on Cancer tumor, lymph node, and metastases systems. Tumor grade can be classified based on the French Federation of Cancer Centers Sarcoma Group system or the Broder's system that incorporates tumor differentiation, mitotic count, and tumor necrosis. This review is a series of articles discussing uterine sarcoma, and this is Part I, which focuses on one of the subtypes of uterine sarcomas—uterine leiomyosarcoma. The clinical characteristics, diagnosis, outcome, and recent advances are summarized in this article.

AB - Uterine sarcomas account for 3–7% of all uterine cancers. Because of their rarity, unknown etiology, and highly divergent genetic aberration, there is a lack of consensus on risk factors for occurrence and predictive poor outcomes as well as optimal therapeutic choices. Tumor types according to the World Health Organization classification include leiomyosarcoma, endometrial stroma sarcoma, and undifferentiated sarcoma. Staging is done using the 2014 Federation International Gynecology and Obstetrics and 2010 American Joint Committee on Cancer tumor, lymph node, and metastases systems. Tumor grade can be classified based on the French Federation of Cancer Centers Sarcoma Group system or the Broder's system that incorporates tumor differentiation, mitotic count, and tumor necrosis. This review is a series of articles discussing uterine sarcoma, and this is Part I, which focuses on one of the subtypes of uterine sarcomas—uterine leiomyosarcoma. The clinical characteristics, diagnosis, outcome, and recent advances are summarized in this article.

KW - diagnosis

KW - leiomyosarcoma

KW - treatment

KW - uterine sarcoma

KW - uterus

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