Uterine sarcoma Part II—Uterine endometrial stromal sarcoma: The TAG systematic review

Huann Cheng Horng, Kuo Chang Wen, Peng Hui Wang, Yi Jen Chen, Ming Shyen Yen, Heung Tat Ng, Yen Hou Chang, Yi Chang, Hsiang Tai Chao, Kuan Chong Chao, Chi Mu Chuang, Chi Hong Ho, Chen Yu Huang, Zhi Chen Hung, Ling Yu Jiang, Hei Yu Lau, Hsin Yang Li, Chi Yao Lin, Chia Hao Liu, Pi Lin SunNae Fang Twu, Hua Hsi Wu, Hann Chin Yu, Fong Yuan Ju, Chih Ping Tsai, Wen Hsun Chang, Yen Mei Hsu, Na Rong Lee, Chih Yao Chen, Ting Chen Chang, Wen Chun Chang, Chii Hou Chen, Ruey Jian Chen, Song Nan Chow, Yih Ron Lien, Bor Ching Sheu, Pao Ling Torng, Men Luh Yen, Wen Ling Lee, Kuan Chin Wang, Chih Long Chang, Chih Ping Chen, Jen Ruei Chen, Tze Chien Chen, Jian Pei Huang, Ming Chao Huang, Yeou Lih Wang, Cheng Chang Chang, Jah Yao Liu, Her Young Su, Yu Chi Wang, Mu Hsien Yu, Lee Wen Huang, Kok Min Seow, Tsung Hsuan Lai, Fa Kung Lee, Ching Hui Chen, Ben Shian Huang, Sheng Mou Hsiao, Hsu Dong Sun, Wen Yih Wu, Sen Wen Teng, Kuo Hu Chen, Jeng Hsiu Hung, Hung Cheng Lai, Chiou Chung Yuan, Ching Hung Hsieh, Chin Jung Wang, Shing Jyh Chang, Man Jung Hung, Shih Tien Hsu, Yu Min Ke, Chien Hsing Lu, Lou Sun, Wei Chun Chang, Yao Ching Hung, Wu Chou Lin, Po Hui Wang, Tze Ho Chen, Yiu Tai Li, Meng Hsing Wu, Kuo Feng Huang, Hung Chun Fu, San Nung Chen, An Jen Chiang, Ju Yueh Li, Li Te Lin, Hsiao Wen Tsai, Kuan Hao Tsui

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Endometrial stromal tumors are rare uterine tumors (<1%). Four main categories include endometrial stromal nodule, low-grade endometrial stromal sarcoma (LG-ESS), high-grade endometrial stromal sarcoma (HG-ESS), and uterine undifferentiated sarcoma (UUS). This review is a series of articles discussing the uterine sarcomas. LG-ESS, a hormone-dependent tumor harboring chromosomal rearrangement, is an indolent tumor with a favorable prognosis, but characterized by late recurrences even in patients with Stage I disease, suggesting the requirement of a long-term follow-up. Patients with HG-ESS, based on the identification of YWHAE-NUTM2A/B (YWHAE-FAM22A/B) gene fusion, typically present with advanced stage diseases and frequently have recurrences, usually within a few years after initial surgery. UUS is, a high-grade sarcoma, extremely rare, lacking a specific line of differentiation, which is a diagnosis of exclusion (the wastebasket category, which fails to fulfill the morphological and immunohistochemical criteria of translocation-positive ESS). Surgery is the main strategy in the management of uterine sarcoma. Due to rarity, complex biological characteristics, and unknown etiology and risk factors of uterine sarcomas, the role of adjuvant therapy is not clear. Only LG-ESS might respond to progestins or aromatase inhibitors.

Original languageEnglish
Pages (from-to)472-479
Number of pages8
JournalTaiwanese Journal of Obstetrics and Gynecology
Volume55
Issue number4
DOIs
Publication statusPublished - Aug 1 2016

Fingerprint

Endometrial Stromal Sarcoma
Endometrial Stromal Tumors
Sarcoma
Recurrence
Neoplasms
Aromatase Inhibitors
Gene Fusion
Progestins
Hormones

Keywords

  • diagnosis
  • endometrial stromal sarcoma
  • treatment
  • undifferentiated sarcoma
  • uterine sarcoma
  • uterus

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Horng, H. C., Wen, K. C., Wang, P. H., Chen, Y. J., Yen, M. S., Ng, H. T., ... Tsui, K. H. (2016). Uterine sarcoma Part II—Uterine endometrial stromal sarcoma: The TAG systematic review. Taiwanese Journal of Obstetrics and Gynecology, 55(4), 472-479. https://doi.org/10.1016/j.tjog.2016.04.034

Uterine sarcoma Part II—Uterine endometrial stromal sarcoma : The TAG systematic review. / Horng, Huann Cheng; Wen, Kuo Chang; Wang, Peng Hui; Chen, Yi Jen; Yen, Ming Shyen; Ng, Heung Tat; Chang, Yen Hou; Chang, Yi; Chao, Hsiang Tai; Chao, Kuan Chong; Chuang, Chi Mu; Ho, Chi Hong; Huang, Chen Yu; Hung, Zhi Chen; Jiang, Ling Yu; Lau, Hei Yu; Li, Hsin Yang; Lin, Chi Yao; Liu, Chia Hao; Sun, Pi Lin; Twu, Nae Fang; Wu, Hua Hsi; Yu, Hann Chin; Ju, Fong Yuan; Tsai, Chih Ping; Chang, Wen Hsun; Hsu, Yen Mei; Lee, Na Rong; Chen, Chih Yao; Chang, Ting Chen; Chang, Wen Chun; Chen, Chii Hou; Chen, Ruey Jian; Chow, Song Nan; Lien, Yih Ron; Sheu, Bor Ching; Torng, Pao Ling; Yen, Men Luh; Lee, Wen Ling; Wang, Kuan Chin; Chang, Chih Long; Chen, Chih Ping; Chen, Jen Ruei; Chen, Tze Chien; Huang, Jian Pei; Huang, Ming Chao; Wang, Yeou Lih; Chang, Cheng Chang; Liu, Jah Yao; Su, Her Young; Wang, Yu Chi; Yu, Mu Hsien; Huang, Lee Wen; Seow, Kok Min; Lai, Tsung Hsuan; Lee, Fa Kung; Chen, Ching Hui; Huang, Ben Shian; Hsiao, Sheng Mou; Sun, Hsu Dong; Wu, Wen Yih; Teng, Sen Wen; Chen, Kuo Hu; Hung, Jeng Hsiu; Lai, Hung Cheng; Yuan, Chiou Chung; Hsieh, Ching Hung; Wang, Chin Jung; Chang, Shing Jyh; Hung, Man Jung; Hsu, Shih Tien; Ke, Yu Min; Lu, Chien Hsing; Sun, Lou; Chang, Wei Chun; Hung, Yao Ching; Lin, Wu Chou; Wang, Po Hui; Chen, Tze Ho; Li, Yiu Tai; Wu, Meng Hsing; Huang, Kuo Feng; Fu, Hung Chun; Chen, San Nung; Chiang, An Jen; Li, Ju Yueh; Lin, Li Te; Tsai, Hsiao Wen; Tsui, Kuan Hao.

In: Taiwanese Journal of Obstetrics and Gynecology, Vol. 55, No. 4, 01.08.2016, p. 472-479.

Research output: Contribution to journalReview article

Horng, HC, Wen, KC, Wang, PH, Chen, YJ, Yen, MS, Ng, HT, Chang, YH, Chang, Y, Chao, HT, Chao, KC, Chuang, CM, Ho, CH, Huang, CY, Hung, ZC, Jiang, LY, Lau, HY, Li, HY, Lin, CY, Liu, CH, Sun, PL, Twu, NF, Wu, HH, Yu, HC, Ju, FY, Tsai, CP, Chang, WH, Hsu, YM, Lee, NR, Chen, CY, Chang, TC, Chang, WC, Chen, CH, Chen, RJ, Chow, SN, Lien, YR, Sheu, BC, Torng, PL, Yen, ML, Lee, WL, Wang, KC, Chang, CL, Chen, CP, Chen, JR, Chen, TC, Huang, JP, Huang, MC, Wang, YL, Chang, CC, Liu, JY, Su, HY, Wang, YC, Yu, MH, Huang, LW, Seow, KM, Lai, TH, Lee, FK, Chen, CH, Huang, BS, Hsiao, SM, Sun, HD, Wu, WY, Teng, SW, Chen, KH, Hung, JH, Lai, HC, Yuan, CC, Hsieh, CH, Wang, CJ, Chang, SJ, Hung, MJ, Hsu, ST, Ke, YM, Lu, CH, Sun, L, Chang, WC, Hung, YC, Lin, WC, Wang, PH, Chen, TH, Li, YT, Wu, MH, Huang, KF, Fu, HC, Chen, SN, Chiang, AJ, Li, JY, Lin, LT, Tsai, HW & Tsui, KH 2016, 'Uterine sarcoma Part II—Uterine endometrial stromal sarcoma: The TAG systematic review', Taiwanese Journal of Obstetrics and Gynecology, vol. 55, no. 4, pp. 472-479. https://doi.org/10.1016/j.tjog.2016.04.034
Horng, Huann Cheng ; Wen, Kuo Chang ; Wang, Peng Hui ; Chen, Yi Jen ; Yen, Ming Shyen ; Ng, Heung Tat ; Chang, Yen Hou ; Chang, Yi ; Chao, Hsiang Tai ; Chao, Kuan Chong ; Chuang, Chi Mu ; Ho, Chi Hong ; Huang, Chen Yu ; Hung, Zhi Chen ; Jiang, Ling Yu ; Lau, Hei Yu ; Li, Hsin Yang ; Lin, Chi Yao ; Liu, Chia Hao ; Sun, Pi Lin ; Twu, Nae Fang ; Wu, Hua Hsi ; Yu, Hann Chin ; Ju, Fong Yuan ; Tsai, Chih Ping ; Chang, Wen Hsun ; Hsu, Yen Mei ; Lee, Na Rong ; Chen, Chih Yao ; Chang, Ting Chen ; Chang, Wen Chun ; Chen, Chii Hou ; Chen, Ruey Jian ; Chow, Song Nan ; Lien, Yih Ron ; Sheu, Bor Ching ; Torng, Pao Ling ; Yen, Men Luh ; Lee, Wen Ling ; Wang, Kuan Chin ; Chang, Chih Long ; Chen, Chih Ping ; Chen, Jen Ruei ; Chen, Tze Chien ; Huang, Jian Pei ; Huang, Ming Chao ; Wang, Yeou Lih ; Chang, Cheng Chang ; Liu, Jah Yao ; Su, Her Young ; Wang, Yu Chi ; Yu, Mu Hsien ; Huang, Lee Wen ; Seow, Kok Min ; Lai, Tsung Hsuan ; Lee, Fa Kung ; Chen, Ching Hui ; Huang, Ben Shian ; Hsiao, Sheng Mou ; Sun, Hsu Dong ; Wu, Wen Yih ; Teng, Sen Wen ; Chen, Kuo Hu ; Hung, Jeng Hsiu ; Lai, Hung Cheng ; Yuan, Chiou Chung ; Hsieh, Ching Hung ; Wang, Chin Jung ; Chang, Shing Jyh ; Hung, Man Jung ; Hsu, Shih Tien ; Ke, Yu Min ; Lu, Chien Hsing ; Sun, Lou ; Chang, Wei Chun ; Hung, Yao Ching ; Lin, Wu Chou ; Wang, Po Hui ; Chen, Tze Ho ; Li, Yiu Tai ; Wu, Meng Hsing ; Huang, Kuo Feng ; Fu, Hung Chun ; Chen, San Nung ; Chiang, An Jen ; Li, Ju Yueh ; Lin, Li Te ; Tsai, Hsiao Wen ; Tsui, Kuan Hao. / Uterine sarcoma Part II—Uterine endometrial stromal sarcoma : The TAG systematic review. In: Taiwanese Journal of Obstetrics and Gynecology. 2016 ; Vol. 55, No. 4. pp. 472-479.
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abstract = "Endometrial stromal tumors are rare uterine tumors (<1{\%}). Four main categories include endometrial stromal nodule, low-grade endometrial stromal sarcoma (LG-ESS), high-grade endometrial stromal sarcoma (HG-ESS), and uterine undifferentiated sarcoma (UUS). This review is a series of articles discussing the uterine sarcomas. LG-ESS, a hormone-dependent tumor harboring chromosomal rearrangement, is an indolent tumor with a favorable prognosis, but characterized by late recurrences even in patients with Stage I disease, suggesting the requirement of a long-term follow-up. Patients with HG-ESS, based on the identification of YWHAE-NUTM2A/B (YWHAE-FAM22A/B) gene fusion, typically present with advanced stage diseases and frequently have recurrences, usually within a few years after initial surgery. UUS is, a high-grade sarcoma, extremely rare, lacking a specific line of differentiation, which is a diagnosis of exclusion (the wastebasket category, which fails to fulfill the morphological and immunohistochemical criteria of translocation-positive ESS). Surgery is the main strategy in the management of uterine sarcoma. Due to rarity, complex biological characteristics, and unknown etiology and risk factors of uterine sarcomas, the role of adjuvant therapy is not clear. Only LG-ESS might respond to progestins or aromatase inhibitors.",
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T2 - The TAG systematic review

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AU - Wen, Kuo Chang

AU - Wang, Peng Hui

AU - Chen, Yi Jen

AU - Yen, Ming Shyen

AU - Ng, Heung Tat

AU - Chang, Yen Hou

AU - Chang, Yi

AU - Chao, Hsiang Tai

AU - Chao, Kuan Chong

AU - Chuang, Chi Mu

AU - Ho, Chi Hong

AU - Huang, Chen Yu

AU - Hung, Zhi Chen

AU - Jiang, Ling Yu

AU - Lau, Hei Yu

AU - Li, Hsin Yang

AU - Lin, Chi Yao

AU - Liu, Chia Hao

AU - Sun, Pi Lin

AU - Twu, Nae Fang

AU - Wu, Hua Hsi

AU - Yu, Hann Chin

AU - Ju, Fong Yuan

AU - Tsai, Chih Ping

AU - Chang, Wen Hsun

AU - Hsu, Yen Mei

AU - Lee, Na Rong

AU - Chen, Chih Yao

AU - Chang, Ting Chen

AU - Chang, Wen Chun

AU - Chen, Chii Hou

AU - Chen, Ruey Jian

AU - Chow, Song Nan

AU - Lien, Yih Ron

AU - Sheu, Bor Ching

AU - Torng, Pao Ling

AU - Yen, Men Luh

AU - Lee, Wen Ling

AU - Wang, Kuan Chin

AU - Chang, Chih Long

AU - Chen, Chih Ping

AU - Chen, Jen Ruei

AU - Chen, Tze Chien

AU - Huang, Jian Pei

AU - Huang, Ming Chao

AU - Wang, Yeou Lih

AU - Chang, Cheng Chang

AU - Liu, Jah Yao

AU - Su, Her Young

AU - Wang, Yu Chi

AU - Yu, Mu Hsien

AU - Huang, Lee Wen

AU - Seow, Kok Min

AU - Lai, Tsung Hsuan

AU - Lee, Fa Kung

AU - Chen, Ching Hui

AU - Huang, Ben Shian

AU - Hsiao, Sheng Mou

AU - Sun, Hsu Dong

AU - Wu, Wen Yih

AU - Teng, Sen Wen

AU - Chen, Kuo Hu

AU - Hung, Jeng Hsiu

AU - Lai, Hung Cheng

AU - Yuan, Chiou Chung

AU - Hsieh, Ching Hung

AU - Wang, Chin Jung

AU - Chang, Shing Jyh

AU - Hung, Man Jung

AU - Hsu, Shih Tien

AU - Ke, Yu Min

AU - Lu, Chien Hsing

AU - Sun, Lou

AU - Chang, Wei Chun

AU - Hung, Yao Ching

AU - Lin, Wu Chou

AU - Wang, Po Hui

AU - Chen, Tze Ho

AU - Li, Yiu Tai

AU - Wu, Meng Hsing

AU - Huang, Kuo Feng

AU - Fu, Hung Chun

AU - Chen, San Nung

AU - Chiang, An Jen

AU - Li, Ju Yueh

AU - Lin, Li Te

AU - Tsai, Hsiao Wen

AU - Tsui, Kuan Hao

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Endometrial stromal tumors are rare uterine tumors (<1%). Four main categories include endometrial stromal nodule, low-grade endometrial stromal sarcoma (LG-ESS), high-grade endometrial stromal sarcoma (HG-ESS), and uterine undifferentiated sarcoma (UUS). This review is a series of articles discussing the uterine sarcomas. LG-ESS, a hormone-dependent tumor harboring chromosomal rearrangement, is an indolent tumor with a favorable prognosis, but characterized by late recurrences even in patients with Stage I disease, suggesting the requirement of a long-term follow-up. Patients with HG-ESS, based on the identification of YWHAE-NUTM2A/B (YWHAE-FAM22A/B) gene fusion, typically present with advanced stage diseases and frequently have recurrences, usually within a few years after initial surgery. UUS is, a high-grade sarcoma, extremely rare, lacking a specific line of differentiation, which is a diagnosis of exclusion (the wastebasket category, which fails to fulfill the morphological and immunohistochemical criteria of translocation-positive ESS). Surgery is the main strategy in the management of uterine sarcoma. Due to rarity, complex biological characteristics, and unknown etiology and risk factors of uterine sarcomas, the role of adjuvant therapy is not clear. Only LG-ESS might respond to progestins or aromatase inhibitors.

AB - Endometrial stromal tumors are rare uterine tumors (<1%). Four main categories include endometrial stromal nodule, low-grade endometrial stromal sarcoma (LG-ESS), high-grade endometrial stromal sarcoma (HG-ESS), and uterine undifferentiated sarcoma (UUS). This review is a series of articles discussing the uterine sarcomas. LG-ESS, a hormone-dependent tumor harboring chromosomal rearrangement, is an indolent tumor with a favorable prognosis, but characterized by late recurrences even in patients with Stage I disease, suggesting the requirement of a long-term follow-up. Patients with HG-ESS, based on the identification of YWHAE-NUTM2A/B (YWHAE-FAM22A/B) gene fusion, typically present with advanced stage diseases and frequently have recurrences, usually within a few years after initial surgery. UUS is, a high-grade sarcoma, extremely rare, lacking a specific line of differentiation, which is a diagnosis of exclusion (the wastebasket category, which fails to fulfill the morphological and immunohistochemical criteria of translocation-positive ESS). Surgery is the main strategy in the management of uterine sarcoma. Due to rarity, complex biological characteristics, and unknown etiology and risk factors of uterine sarcomas, the role of adjuvant therapy is not clear. Only LG-ESS might respond to progestins or aromatase inhibitors.

KW - diagnosis

KW - endometrial stromal sarcoma

KW - treatment

KW - undifferentiated sarcoma

KW - uterine sarcoma

KW - uterus

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