Using the galectin-3 test to predict mortality in heart failure patients: A systematic review and meta-analysis

Yueh Sheng Chen, Weng Tein Gi, Tin Yun Liao, Meng Tse Gabriel Lee, Si Huei Lee, Wan Ting Hsu, Shy Shin Chang, Chien Chang Lee

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Aim: Galectin-3 (Gal-3) is a new biomarker for assessing prognosis of heart failure (HF) patients. This systemic review and meta-analysis aims to examine Gal-3's ability in assessing prognosis of HF patients. Method: We searched MEDLINE and Embase up to November 2014. Test performance characteristics were summarized using forest plots and hierarchical summary receiver operating characteristic curves. Results: The diagnostic odds ratio of Gal-3 in predicting mortality in chronic HF patients was 2.36 (95% CI: 1.71-3.26) and 2.30 (95% CI: 1.76-3.01) in acute HF patients. Conclusion: Elevated levels of Gal-3 are associated with mortality in both acute and chronic HF patients. However, current evidence does not support sole use of Gal-3 for prognosis evaluation of HF patients.

Original languageEnglish
Pages (from-to)329-342
Number of pages14
JournalBiomarkers in Medicine
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 1 2016
Externally publishedYes

Fingerprint

Galectin 3
Meta-Analysis
Heart Failure
Mortality
Biomarkers
MEDLINE
ROC Curve
Odds Ratio

Keywords

  • Galectin-3
  • heart failure
  • prognostic marker

ASJC Scopus subject areas

  • Drug Discovery
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Chen, Y. S., Gi, W. T., Liao, T. Y., Lee, M. T. G., Lee, S. H., Hsu, W. T., ... Lee, C. C. (2016). Using the galectin-3 test to predict mortality in heart failure patients: A systematic review and meta-analysis. Biomarkers in Medicine, 10(3), 329-342. https://doi.org/10.2217/bmm.15.121

Using the galectin-3 test to predict mortality in heart failure patients : A systematic review and meta-analysis. / Chen, Yueh Sheng; Gi, Weng Tein; Liao, Tin Yun; Lee, Meng Tse Gabriel; Lee, Si Huei; Hsu, Wan Ting; Chang, Shy Shin; Lee, Chien Chang.

In: Biomarkers in Medicine, Vol. 10, No. 3, 01.03.2016, p. 329-342.

Research output: Contribution to journalReview article

Chen, Yueh Sheng ; Gi, Weng Tein ; Liao, Tin Yun ; Lee, Meng Tse Gabriel ; Lee, Si Huei ; Hsu, Wan Ting ; Chang, Shy Shin ; Lee, Chien Chang. / Using the galectin-3 test to predict mortality in heart failure patients : A systematic review and meta-analysis. In: Biomarkers in Medicine. 2016 ; Vol. 10, No. 3. pp. 329-342.
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