Using k-mer embeddings learned from a Skip-gram based neural network for building a cross-species DNA N6-methyladenine site prediction model

Trinh Trung Duong Nguyen, Van Ngu Trinh, Nguyen Quoc Khanh Le, Yu Yen Ou

Research output: Contribution to journalArticlepeer-review

Abstract

Key message: This study used k-mer embeddings as effective feature to identify DNA N6-Methyladenine sites in plant genomes and obtained improved performance without substantial effort in feature extraction, combination and selection. Abstract: Identification of DNA N6-methyladenine sites has been a very active topic of computational biology due to the unavailability of suitable methods to identify them accurately, especially in plants. Substantial results were obtained with a great effort put in extracting, heuristic searching, or fusing a diverse types of features, not to mention a feature selection step. In this study, we regarded DNA sequences as textual information and employed natural language processing techniques to decipher hidden biological meanings from those sequences. In other words, we considered DNA, the human life book, as a book corpus for training DNA language models. K-mer embeddings then were generated from these language models to be used in machine learning prediction models. Skip-gram neural networks were the base of the language models and ensemble tree-based algorithms were the machine learning algorithms for prediction models. We trained the prediction model on Rosaceae genome dataset and performed a comprehensive test on 3 plant genome datasets. Our proposed method shows promising performance with AUC performance approaching an ideal value on Rosaceae dataset (0.99), a high score on Rice dataset (0.95) and improved performance on Rice dataset while enjoying an elegant, yet efficient feature extraction process.

Original languageEnglish
Pages (from-to)533-542
Number of pages10
JournalPlant Molecular Biology
Volume107
Issue number6
DOIs
Publication statusPublished - Dec 2021

Keywords

  • DNA N-methyladenine site prediction
  • Ensemble tree-based algorithms
  • k-mer embeddings
  • Natural language processing

ASJC Scopus subject areas

  • Genetics
  • Agronomy and Crop Science
  • Plant Science

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