@article{c1dc255dc49e4e05a8ba944b0826737b,
title = "Using fMRI to decode true thoughts independent of intention to conceal",
abstract = "Multi-variate pattern analysis (MVPA) applied to BOLD-fMRI has proven successful at decoding complicated fMRI signal patterns associated with a variety of cognitive processes. One cognitive process, not yet investigated, is the mental representation of {"}Yes/No{"} thoughts that precede the actual overt response to a binary {"}Yes/No{"} question. In this study, we focus on examining: (1) whether spatial patterns of the hemodynamic response carry sufficient information to allow reliable decoding of {"}Yes/No{"} thoughts; and (2) whether decoding of {"}Yes/No{"} thoughts is independent of the intention to respond honestly or dishonestly. To achieve this goal, we conducted two separate experiments. Experiment 1, collected on a 3T scanner, examined the whole brain to identify regions that carry sufficient information to permit significantly above-chance prediction of {"}Yes/No{"} thoughts at the group level. In Experiment 2, collected on a 7T scanner, we focused on the regions identified in Experiment 1 to examine the capability of achieving high decoding accuracy at the single subject level. A set of regions - namely right superior temporal gyrus, left supra-marginal gyrus, and left middle frontal gyrus - exhibited high decoding power. Decoding accuracy for these regions increased with trial averaging. When 18 trials were averaged, the median accuracies were 82.5%, 77.5%, and 79.5%, respectively. When trials were separated according to deceptive intentions (set via experimental cues), and classifiers were trained on honest trials, but tested on trials where subjects were asked to deceive, the median accuracies of these regions still reached 66%, 75%, and 78.5%. These results provide evidence that concealed {"}Yes/No{"} thoughts are encoded in the BOLD signal, retaining some level of independence from the subject's intentions to answer honestly or dishonestly. These findings also suggest the theoretical possibility for more efficient brain-computer interfaces where subjects only need to think their answers to communicate. {\textcopyright} 2014 Elsevier Inc.",
keywords = "Deception, Dorsolateral prefrontal cortex, FMRI, Multivariate pattern analysis, Searchlight, adult, article, behavior, BOLD signal, brain computer interface, college student, controlled study, deception, female, functional magnetic resonance imaging, functional neuroimaging, human, human experiment, image analysis, intention to conceal, male, mental capacity, mental performance, middle frontal gyrus, parahippocampal gyrus, priority journal, spatial orientation, superior temporal gyrus, supramarginal gyrus, thinking, visual information, brain, brain cortex, forensic medicine, image processing, nuclear magnetic resonance imaging, photostimulation, physiology, procedures, psychology, reproducibility, young adult, Adult, Brain, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Intention, Lie Detection, Magnetic Resonance Imaging, Male, Photic Stimulation, Reproducibility of Results, Young Adult",
author = "Zhi Yang and Zirui Huang and Javier Gonzalez-Castillo and Rui Dai and G. Northoff and Bandettini, {Peter A.}",
note = "Cited By :4 Export Date: 11 May 2016 CODEN: NEIME Correspondence Address: Yang, Z.; Key Laboratory of Behavioral Sciences, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing, 100101, China; email: yangz@psych.ac.cn Funding Details: 81270023, NSFC, National Natural Science Foundation of China References: Abe, N., The neurobiology of deception: evidence from neuroimaging and loss-of-function studies (2009) Curr. Opin. Neurol., 22, p. 594; Abe, N., Okuda, J., Suzuki, M., Sasaki, H., Matsuda, T., Mori, E., Tsukada, M., Fujii, T., Neural correlates of true memory, false memory, and deception (2008) Cereb. Cortex, 18, p. 2811; Barber, A.D., Carter, C.S., Cognitive control involved in overcoming prepotent response tendencies and switching between tasks (2005) Cereb. Cortex, 15, pp. 899-912; Buxton, R.B., Dynamic models of BOLD contrast (2012) NeuroImage, 62, pp. 953-961; Christ, S.E., Van Essen, D.C., Watson, J.M., Brubaker, L.E., McDermott, K.B., The contributions of prefrontal cortex and executive control to deception: evidence from activation likelihood estimate meta-analyses (2009) Cereb. Cortex, 19, pp. 1557-1566; Coutanche, M.N., Thompson-Schill, S.L., Schultz, R.T., Multi-voxel pattern analysis of fMRI data predicts clinical symptom severity (2011) NeuroImage, 57, pp. 113-123; Cox, R.W., AFNI: software for analysis and visualization of functional magnetic resonance neuroimages (1996) Comput. Biomed. Res., 29, pp. 162-173; {\c C}ukur, T., Nishimoto, S., Huth, A.G., Gallant, J.L., Attention during natural vision warps semantic representation across the human brain (2013) Nat. Neurosci., 16, pp. 763-770; Druzgal, T.J., D'Esposito, M., A neural network reflecting decisions about human faces (2001) Neuron, 32, pp. 947-955; Eickhoff, S.B., Stephan, K.E., Mohlberg, H., Grefkes, C., Fink, G.R., Amunts, K., Zilles, K., A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data (2005) NeuroImage, 25, pp. 1325-1335; Etzel, J.A., Zacks, J.M., Braver, T.S., Searchlight analysis: promise, pitfalls, and potential (2013) NeuroImage, 78, pp. 261-269; Fox, P.T., The coupling controversy (2012) NeuroImage, 62, pp. 594-601; Fox, C.J., Iaria, G., Barton, J.J.S., Defining the face processing network: optimization of the functional localizer in fMRI (2009) Hum. Brain Mapp., 30, pp. 1637-1651; Gobbini, M.I., Haxby, J.V., Neural response to the visual familiarity of faces (2006) Brain Res. Bull., 71, pp. 76-82; Gobbini, M.I., Haxby, J.V., Neural systems for recognition of familiar faces (2007) Neuropsychologia, 45, pp. 32-41; Gonzalez-Castillo, J., Saad, Z.S., Handwerker, D.A., Inati, S.J., Brenowitz, N., Bandettini, P.A., Whole-brain, time-locked activation with simple tasks revealed using massive averaging and model-free analysis (2012) Proc. Natl. Acad. Sci. U. S. A., 109, pp. 5487-5492; Gonzalez-Castillo, J., Duthie, K.N., Saad, Z.S., Chu, C., Bandettini, P.A., Luh, W.M., Effects of image contrast on functional MRI image registration (2013) NeuroImage, 67, pp. 163-174; Hampton, A.N., O'Doherty, J.P., Decoding the neural substrates of reward-related decision making with functional MRI (2007) Proc. Natl. Acad. Sci. U. S. A., 104, pp. 1377-1382; Haxby, J.V., Gobbini, M.I., Furey, M.L., Ishai, A., Schouten, J.L., Pietrini, P., Distributed and overlapping representations of faces and objects in ventral temporal cortex (2001) Science, 293, p. 2425; Haynes, J.D., Rees, G., Decoding mental states from brain activity in humans (2006) Nat. Rev. Neurosci., 7, pp. 523-534; Haynes, J.D., Sakai, K., Rees, G., Gilbert, S., Frith, C., Passingham, R.E., Reading hidden intentions in the human brain (2007) Curr. Biol., 17, pp. 323-328; Heeger, D.J., Ress, D., What does fMRI tell us about neuronal activity? (2002) Nat. Rev. Neurosci., 3, pp. 142-151; Heekeren, H.R., Marrett, S., Bandettini, P.A., Ungerleider, L.G., A general mechanism for perceptual decision-making in the human brain (2004) Nature, 431, pp. 859-862; Heekeren, H.R., Marrett, S., Ruff, D.A., Bandettini, P.A., Ungerleider, L.G., Involvement of human left dorsolateral prefrontal cortex in perceptual decision making is independent of response modality (2006) Proc. Natl. Acad. Sci. U. S. A., 103, pp. 10023-10028; Henson, R.N., Burgess, N., Frith, C.D., Recoding, storage, rehearsal and grouping in verbal short-term memory: an fMRI study (2000) Neuropsychologia, 38, pp. 426-440; Jobard, G., Crivello, F., Tzourio-Mazoyer, N., Evaluation of the dual route theory of reading: a metanalysis of 35 neuroimaging studies (2003) NeuroImage, 20, pp. 693-712; Johnson, R., Barnhardt, J., Zhu, J., The contribution of executive processes to deceptive responding (2004) Neuropsychologia, 42, pp. 878-901; Kim, J.N., Shadlen, M.N., Neural correlates of a decision in the dorsolateral prefrontal cortex of the macaque (1999) Nat. Neurosci., 2, pp. 176-185; Kowalczyk, A., Chapelle, O., An analysis of the anti-learning phenomenon for the class symmetric polyhedron (2005) Algorithmic learning theory, pp. 78-91. , Springer, Berlin Heidelberg, S. Jain, H. Simon, E. Tomita (Eds.); Kriegeskorte, N., Goebel, R., Bandettini, P., Information-based functional brain mapping (2006) Proc. Natl. Acad. Sci. U. S. A., 103, pp. 3863-3868; Langleben, D.D., Schroeder, L., Maldjian, J.A., Gur, R.C., McDonald, S., Ragland, J.D., O'Brien, C.P., Childress, A.R., Brain activity during simulated deception: an event-related functional magnetic resonance study (2002) NeuroImage, 15, pp. 727-732; Langleben, D.D., Loughead, J.W., Bilker, W.B., Ruparel, K., Childress, A.R., Busch, S.I., Gur, R.C., Telling truth from lie in individual subjects with fast event-related fMRI (2005) Hum. Brain Mapp., 26, pp. 262-272; Logothetis, N.K., Pauls, J., Augath, M., Trinath, T., Oeltermann, A., Neurophysiological investigation of the basis of the fMRI signal (2001) Nature, 412, pp. 150-157; Meiran, N., Chorev, Z., Sapir, A., Component processes in task switching (2000) Cogn. Psychol., 41, pp. 211-253; Meyer, K., Kaplan, J.T., Essex, R., Webber, C., Damasio, H., Damasio, A., Predicting visual stimuli on the basis of activity in auditory cortices (2010) Nat. Neurosci., 13, pp. 667-668; Misaki, M., Kim, Y., Bandettini, P.A., Kriegeskorte, N., Comparison of multivariate classifiers and response normalizations for pattern-information fMRI (2010) NeuroImage, 53, pp. 103-118; Mitchell, T., Hutchinson, R., Niculescu, R., Pereira, F., Wang, X., Just, M., Newman, S., Learning to decode cognitive states from brain images (2004) Mach. Learn., 13, pp. 667-668; Monti, M.M., Vanhaudenhuyse, A., Coleman, M.R., Boly, M., Pickard, J.D., Tshibanda, L., Owen, A.M., Laureys, S., Willful modulation of brain activity in disorders of consciousness (2010) N. Engl. J. Med., 362, pp. 579-589; Naci, L., Cusack, R., Jia, V.Z., Owen, A.M., The Brain's silent messenger: using selective attention to decode human thought for brain-based communication (2013) J. Neurosci., 33, pp. 9385-9393; Norman, K.A., Polyn, S.M., Detre, G.J., Haxby, J.V., Beyond mind-reading: multi-voxel pattern analysis of fMRI data (2006) Trends Cogn. Sci., 10, pp. 424-430; Owen, A.M., Coleman, M.R., Boly, M., Davis, M.H., Laureys, S., Pickard, J.D., Detecting awareness in the vegetative state (2006) Science, 313, p. 1402; Paulesu, E., Frith, C.D., Frackowiak, R.S., The neural correlates of the verbal component of working memory (1993) Nature, 362, pp. 342-345; Phan, K.L., Magalhaes, A., Ziemlewicz, T.J., Fitzgerald, D.A., Green, C., Smith, W., Neural correlates of telling lies: a functional magnetic resonance imaging study at 4 Tesla (2005) Acad. Radiol., 12, pp. 164-172; Pleger, B., Ruff, C.C., Blankenburg, F., Bestmann, S., Wiech, K., Stephan, K.E., Capilla, A., Dolan, R.J., Neural coding of tactile decisions in the human prefrontal cortex (2006) J. Neurosci., 26, pp. 12596-12601; Price, C.J., The anatomy of language: a review of 100 fMRI studies published in 2009 (2010) Ann. N. Y. Acad. Sci., 1191, pp. 62-88; Rissman, J., Greely, H.T., Wagner, A.D., Detecting individual memories through the neural decoding of memory states and past experience (2010) Proc. Natl. Acad. Sci. U. S. A., 107, pp. 9849-9854; Simon, O., Mangin, J.F., Cohen, L., Le Bihan, D., Dehaene, S., Topographical layout of hand, eye, calculation, and language-related areas in the human parietal lobe (2002) Neuron, 33, pp. 475-487; Sip, K., Roepstorff, A., McGregor, W., Frith, C., Detecting deception: the scope and limits (2008) Trends Cogn. Sci., 12, pp. 48-53; Sip, K., Lynge, M., Wallentin, M., McGregor, W., Frith, C., Roepstorff, A., The production and detection of deception in an interactive game (2010) Neuropsychologia, 48, pp. 3619-3626; Soon, C.S., Brass, M., Heinze, H.J., Haynes, J.D., Unconscious determinants of free decisions in the human brain (2008) Nat. Neurosci., 11, pp. 543-545; Soon, C.S., He, A.H., Bode, S., Haynes, J.D., Predicting free choices for abstract intentions (2013) Proc. Natl. Acad. Sci. U. S. A., 110, pp. 6217-6222; Spence, S.A., Farrow, T.F., Herford, A.E., Wilkinson, I.D., Zheng, Y., Woodruff, P.W., Behavioural and functional anatomical correlates of deception in humans (2001) Neuroreport, 12, pp. 2849-2853; Spence, S.A., Hunter, M.D., Farrow, T.F., Green, R.D., Leung, D.H., Hughes, C.J., Ganesan, V., A cognitive neurobiological account of deception: evidence from functional neuroimaging (2004) Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci., 359, pp. 1755-1762; Sun, D., Lee, T.M., Chan, C.C., Unfolding the spatial and temporal neural processing of lying about face familiarity (2013) Cereb. Cortex, , (Epub ahead of print); Talairach, J., Tournoux, P., (1988) Co-planar stereotaxic atlas of the human brain, , G. Thieme; Thieme Medical Publishers, Stuttgart; New York; Xiong, J., Gao, J.-H., Lancaster, J.L., Fox, P.T., Clustered pixels analysis for functional MRI activation studies of the human brain (1995) Hum. Brain Mapp., 3, pp. 287-301; Xu, G., Jiang, Y., Ma, L., Yang, Z., Weng, X., Similar spatial patterns of neural coding of category selectivity in FFA and VWFA under different attention conditions (2012) Neuropsychologia, 50, pp. 862-868; Yacoub, E., Shmuel, A., Pfeuffer, J., Van De Moortele, P.F., Adriany, G., Ugurbil, K., Hu, X.P., Investigation of the initial dip in fMRI at 7 Tesla (2001) NMR Biomed., 14, pp. 408-412; Yang, Z., Fang, F., Weng, X., Recent developments in multivariate pattern analysis for functional MRI (2012) Neurosci. Bull., 28, pp. 399-408",
year = "2014",
doi = "10.1016/j.neuroimage.2014.05.034",
language = "English",
volume = "99",
pages = "80--92",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
}
