Usefulness of the CHADS2 Score for Determining Risk of Seizure in Patients With Atrial Fibrillation

Chien Yi Hsu, Tz Heng Chen, Yu Wen Su, Chun Chin Chang, Mu Hong Chen, Hsin Bang Leu, Po Hsun Huang, Jaw Wen Chen, Shing Jong Lin

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Atrial fibrillation (AF) secondary to seizure has been described in case reports, but the association between AF and risk of seizure has never been evaluated in longitudinal studies. The objectives of this study were to investigate the role of AF on the risk of development of seizure and the usefulness of CHADS2 score for predicting the risk of seizure. Our analyses were conducted using information from a random sample of 1 million subjects enrolled in Taiwan National Health Insurance Research Database. A total of 11,552 subjects aged ≥18 years, comprising 5,776 subjects diagnosed with AF during the study period and 5,776 age and sex-matched subjects without AF were enrolled in our study. During the mean follow-up of 6.7 ± 3.3 years, seizure events occurred in 235 patients. In comparison, the AF group had a higher incidence rate of seizure occurrence (4.17 vs 1.90 per 1,000 person-years). Cox proportional hazard regression model analysis showed that development of AF was independently associated with a higher risk of developing future seizure (adjusted HR 2.30; 95% confidence interval 1.73 to 3.05). In multivariate Cox regression analysis adjusted for potentially confounding variables, a higher CHADS2 score was associated with a higher risk of seizure in a dose-dependent manner. AF may cause an ischemic stroke that subsequently leads to seizure, and present study further demonstrates that AF patients are associated with higher rate of subsequent seizure, even after adjusting for stroke. The CHADS2 score was found to be a useful scheme for predicting the risk of seizure occurrence.

Original languageEnglish
Pages (from-to)1340-1344
Number of pages5
JournalAmerican Journal of Cardiology
Volume118
Issue number9
DOIs
Publication statusPublished - Nov 1 2016

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Atrial Fibrillation
Seizures
Stroke
Regression Analysis
Confounding Factors (Epidemiology)
National Health Programs
Taiwan
Proportional Hazards Models
Longitudinal Studies
Databases
Confidence Intervals
Incidence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Usefulness of the CHADS2 Score for Determining Risk of Seizure in Patients With Atrial Fibrillation. / Hsu, Chien Yi; Chen, Tz Heng; Su, Yu Wen; Chang, Chun Chin; Chen, Mu Hong; Leu, Hsin Bang; Huang, Po Hsun; Chen, Jaw Wen; Lin, Shing Jong.

In: American Journal of Cardiology, Vol. 118, No. 9, 01.11.2016, p. 1340-1344.

Research output: Contribution to journalArticle

Hsu, CY, Chen, TH, Su, YW, Chang, CC, Chen, MH, Leu, HB, Huang, PH, Chen, JW & Lin, SJ 2016, 'Usefulness of the CHADS2 Score for Determining Risk of Seizure in Patients With Atrial Fibrillation', American Journal of Cardiology, vol. 118, no. 9, pp. 1340-1344. https://doi.org/10.1016/j.amjcard.2016.07.063
Hsu, Chien Yi ; Chen, Tz Heng ; Su, Yu Wen ; Chang, Chun Chin ; Chen, Mu Hong ; Leu, Hsin Bang ; Huang, Po Hsun ; Chen, Jaw Wen ; Lin, Shing Jong. / Usefulness of the CHADS2 Score for Determining Risk of Seizure in Patients With Atrial Fibrillation. In: American Journal of Cardiology. 2016 ; Vol. 118, No. 9. pp. 1340-1344.
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