Usefulness of fecal lactoferrin in predicting and monitoring the clinical severity of infectious diarrhea

Chien Chang Chen, Chee Jen Chang, Tzou Yien Lin, Ming Wei Lai, Hsun Chin Chao, Man Shan Kong

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

AIM: To explore the value of fecal lactoferrin in predicting and monitoring the clinical severity of infectious diarrhea. METHODS: Patients with acute infectious diarrhea ranging from 3 mo to 10 years in age were enrolled, and one to three stool samples from each subject were collected. Certain parameters, including white blood cells /differential count, C-reactive protein, fecal mucus, fecal pus cells, duration of fever, vomiting, diarrhea and severity (indicated by Clark and Vesikari scores), were recorded and analyzed. Fecal lactoferrin was determined by enzyme-linked immunosorbent assay and compared in different pathogen and disease activity. Generalized estimating equations (GEE) were also used for analysis. RESULTS: Data included 226 evaluations for 117 individuals across three different time points. Fecal lactoferrin was higher in patients with Salmonella (11.17 μg/g ± 2.73 μg/g) or Campylobacter (10.32 μg/g ± 2.94 μg/g) infections and lower in patients with rotavirus (2.82 μg/g ± 1.27 μg/g) or norovirus (3.16 μg/g ± 1.18 μg/g) infections. Concentrations of fecal lactoferrin were significantly elevated in patients with severe (11.32 μg/g ± 3.29 μg/g) or moderate (3.77 μg/g ± 2.08 μg/g) disease activity compared with subjects with mild (1.51 μg/g ± 1.36 μg/g) disease activity (P < 0.05). GEE analysis suggests that this marker could be used to monitor the severity and course of gastrointestinal infections and may provide information for disease management. CONCLUSION: Fecal lactoferrin increased during bacterial infection and with greater disease severity and may be a good marker for predicting and monitoring intestinal inflammation in children with infectious diarrhea.

Original languageEnglish
Pages (from-to)4218-4224
Number of pages7
JournalWorld Journal of Gastroenterology
Volume17
Issue number37
DOIs
Publication statusPublished - Oct 7 2011
Externally publishedYes

Fingerprint

Lactoferrin
Diarrhea
Infection
Norovirus
Information Management
Campylobacter
Suppuration
Rotavirus
Mucus
Disease Management
Leukocyte Count
Bacterial Infections
Salmonella
C-Reactive Protein
Vomiting
Fever
Enzyme-Linked Immunosorbent Assay
Inflammation

Keywords

  • Clark scores
  • Diarrhea
  • Generalized estimating equations
  • Lactoferrin
  • Vesikari scores

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Usefulness of fecal lactoferrin in predicting and monitoring the clinical severity of infectious diarrhea. / Chen, Chien Chang; Chang, Chee Jen; Lin, Tzou Yien; Lai, Ming Wei; Chao, Hsun Chin; Kong, Man Shan.

In: World Journal of Gastroenterology, Vol. 17, No. 37, 07.10.2011, p. 4218-4224.

Research output: Contribution to journalArticle

Chen, Chien Chang ; Chang, Chee Jen ; Lin, Tzou Yien ; Lai, Ming Wei ; Chao, Hsun Chin ; Kong, Man Shan. / Usefulness of fecal lactoferrin in predicting and monitoring the clinical severity of infectious diarrhea. In: World Journal of Gastroenterology. 2011 ; Vol. 17, No. 37. pp. 4218-4224.
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AU - Chang, Chee Jen

AU - Lin, Tzou Yien

AU - Lai, Ming Wei

AU - Chao, Hsun Chin

AU - Kong, Man Shan

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KW - Generalized estimating equations

KW - Lactoferrin

KW - Vesikari scores

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