Usefulness of 201TL SPECT/CT relative to 18F-FDG PET/CT in detecting recurrent skull base nasopharyngeal carcinoma

Ruoh-Fang Yen, Lai-Lei Ting, Mei-Fang Cheng, Yen-Wen Wu, Kai-Yuan Tzen, Ruey-Long Hong

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

BACKGROUND: This study was designed to compare (201)Tl single photon emission computed tomography (SPECT)/CT with 18-fluoro-2-deoxyglucose ((18)F-FDG) PET/CT in diagnosing recurrent skull base nasopharyngeal carcinoma (NPC).

METHODS: Twenty-seven patients were recruited. Both (201)Tl SPECT/CT and (18)F-FDG PET/CT for each patient were performed at least 4 months later after initial therapy.

RESULTS: The sensitivity and specificity for (201)Tl SPECT/CT were 66.7% and 100%, and those for (18)F-FDG PET/CT were 86.7% and 75.0%. Lesion/background ratios were obtained for the 10 lesions that were both SPECT and PET true positive. For the 8 patients with recurrences in nasopharyngeal regions, PET lesion/background ratios were all higher than SPECT lesion/background ratios. For the 2 patients with intracranial metastases, SPECT lesion/background ratios were higher than PET lesion/background ratios.

CONCLUSION: (201)Tl SPECT/CT is as effective as (18)F-FDG PET/CT in detecting recurrent NPC. For intracranial recurrence, (201)Tl SPECT, because of its high intracranial lesion/background ratio, is probably better than (18)F-FDG PET.

Original languageEnglish
Pages (from-to)717-24
Number of pages8
JournalHead and Neck
Volume31
Issue number6
DOIs
Publication statusPublished - Jun 2009
Externally publishedYes

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Fluorodeoxyglucose F18
Skull Base
Single-Photon Emission-Computed Tomography
Recurrence
Nasopharyngeal carcinoma
Deoxyglucose
Neoplasm Metastasis
Sensitivity and Specificity

Keywords

  • Adult
  • Aged
  • Cohort Studies
  • Female
  • Fluorodeoxyglucose F18
  • Humans
  • Image Interpretation, Computer-Assisted
  • Logistic Models
  • Male
  • Middle Aged
  • Nasopharyngeal Neoplasms/diagnostic imaging
  • Neoplasm Recurrence, Local/diagnostic imaging
  • Positron-Emission Tomography/methods
  • Predictive Value of Tests
  • Probability
  • Prospective Studies
  • ROC Curve
  • Radiopharmaceuticals
  • Sensitivity and Specificity
  • Skull Base/diagnostic imaging
  • Tomography, Emission-Computed, Single-Photon/methods

Cite this

Usefulness of 201TL SPECT/CT relative to 18F-FDG PET/CT in detecting recurrent skull base nasopharyngeal carcinoma. / Yen, Ruoh-Fang; Ting, Lai-Lei; Cheng, Mei-Fang; Wu, Yen-Wen; Tzen, Kai-Yuan; Hong, Ruey-Long.

In: Head and Neck, Vol. 31, No. 6, 06.2009, p. 717-24.

Research output: Contribution to journalArticle

Yen, Ruoh-Fang ; Ting, Lai-Lei ; Cheng, Mei-Fang ; Wu, Yen-Wen ; Tzen, Kai-Yuan ; Hong, Ruey-Long. / Usefulness of 201TL SPECT/CT relative to 18F-FDG PET/CT in detecting recurrent skull base nasopharyngeal carcinoma. In: Head and Neck. 2009 ; Vol. 31, No. 6. pp. 717-24.
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abstract = "BACKGROUND: This study was designed to compare (201)Tl single photon emission computed tomography (SPECT)/CT with 18-fluoro-2-deoxyglucose ((18)F-FDG) PET/CT in diagnosing recurrent skull base nasopharyngeal carcinoma (NPC).METHODS: Twenty-seven patients were recruited. Both (201)Tl SPECT/CT and (18)F-FDG PET/CT for each patient were performed at least 4 months later after initial therapy.RESULTS: The sensitivity and specificity for (201)Tl SPECT/CT were 66.7{\%} and 100{\%}, and those for (18)F-FDG PET/CT were 86.7{\%} and 75.0{\%}. Lesion/background ratios were obtained for the 10 lesions that were both SPECT and PET true positive. For the 8 patients with recurrences in nasopharyngeal regions, PET lesion/background ratios were all higher than SPECT lesion/background ratios. For the 2 patients with intracranial metastases, SPECT lesion/background ratios were higher than PET lesion/background ratios.CONCLUSION: (201)Tl SPECT/CT is as effective as (18)F-FDG PET/CT in detecting recurrent NPC. For intracranial recurrence, (201)Tl SPECT, because of its high intracranial lesion/background ratio, is probably better than (18)F-FDG PET.",
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author = "Ruoh-Fang Yen and Lai-Lei Ting and Mei-Fang Cheng and Yen-Wen Wu and Kai-Yuan Tzen and Ruey-Long Hong",
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T1 - Usefulness of 201TL SPECT/CT relative to 18F-FDG PET/CT in detecting recurrent skull base nasopharyngeal carcinoma

AU - Yen, Ruoh-Fang

AU - Ting, Lai-Lei

AU - Cheng, Mei-Fang

AU - Wu, Yen-Wen

AU - Tzen, Kai-Yuan

AU - Hong, Ruey-Long

N1 - (c) 2009 Wiley Periodicals, Inc.

PY - 2009/6

Y1 - 2009/6

N2 - BACKGROUND: This study was designed to compare (201)Tl single photon emission computed tomography (SPECT)/CT with 18-fluoro-2-deoxyglucose ((18)F-FDG) PET/CT in diagnosing recurrent skull base nasopharyngeal carcinoma (NPC).METHODS: Twenty-seven patients were recruited. Both (201)Tl SPECT/CT and (18)F-FDG PET/CT for each patient were performed at least 4 months later after initial therapy.RESULTS: The sensitivity and specificity for (201)Tl SPECT/CT were 66.7% and 100%, and those for (18)F-FDG PET/CT were 86.7% and 75.0%. Lesion/background ratios were obtained for the 10 lesions that were both SPECT and PET true positive. For the 8 patients with recurrences in nasopharyngeal regions, PET lesion/background ratios were all higher than SPECT lesion/background ratios. For the 2 patients with intracranial metastases, SPECT lesion/background ratios were higher than PET lesion/background ratios.CONCLUSION: (201)Tl SPECT/CT is as effective as (18)F-FDG PET/CT in detecting recurrent NPC. For intracranial recurrence, (201)Tl SPECT, because of its high intracranial lesion/background ratio, is probably better than (18)F-FDG PET.

AB - BACKGROUND: This study was designed to compare (201)Tl single photon emission computed tomography (SPECT)/CT with 18-fluoro-2-deoxyglucose ((18)F-FDG) PET/CT in diagnosing recurrent skull base nasopharyngeal carcinoma (NPC).METHODS: Twenty-seven patients were recruited. Both (201)Tl SPECT/CT and (18)F-FDG PET/CT for each patient were performed at least 4 months later after initial therapy.RESULTS: The sensitivity and specificity for (201)Tl SPECT/CT were 66.7% and 100%, and those for (18)F-FDG PET/CT were 86.7% and 75.0%. Lesion/background ratios were obtained for the 10 lesions that were both SPECT and PET true positive. For the 8 patients with recurrences in nasopharyngeal regions, PET lesion/background ratios were all higher than SPECT lesion/background ratios. For the 2 patients with intracranial metastases, SPECT lesion/background ratios were higher than PET lesion/background ratios.CONCLUSION: (201)Tl SPECT/CT is as effective as (18)F-FDG PET/CT in detecting recurrent NPC. For intracranial recurrence, (201)Tl SPECT, because of its high intracranial lesion/background ratio, is probably better than (18)F-FDG PET.

KW - Adult

KW - Aged

KW - Cohort Studies

KW - Female

KW - Fluorodeoxyglucose F18

KW - Humans

KW - Image Interpretation, Computer-Assisted

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Nasopharyngeal Neoplasms/diagnostic imaging

KW - Neoplasm Recurrence, Local/diagnostic imaging

KW - Positron-Emission Tomography/methods

KW - Predictive Value of Tests

KW - Probability

KW - Prospective Studies

KW - ROC Curve

KW - Radiopharmaceuticals

KW - Sensitivity and Specificity

KW - Skull Base/diagnostic imaging

KW - Tomography, Emission-Computed, Single-Photon/methods

U2 - 10.1002/hed.21026

DO - 10.1002/hed.21026

M3 - Article

C2 - 19189341

VL - 31

SP - 717

EP - 724

JO - Head and Neck

JF - Head and Neck

SN - 1043-3074

IS - 6

ER -