Use of white blood cell counts to predict metabolic syndrome in the elderly: A 4 year longitudinal study

Ting Ting Chao, Chang Hsun Hsieh, Jiunn Diann Lin, Chung Ze Wu, Chun Hsien Hsu, Dee Pei, Yen Lin Chen, Yao Jen Liang, Jin Biou Chang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The white blood cell (WBC) count was one of the first inflammatory markers associated with metabolic syndrome (MetS). Recently, two longitudinal studies have demonstrated a cause and effect relationship between MetS and WBC counts among middle-aged adults. However, no study has used WBC cutoff values to predict MetS in the elderly.

Methods: Subjects who underwent routine health checkups, and were above 60 years of age, were enrolled. All subjects were followed-up until they developed MetS or until 4 years from the date of entry, whichever came earlier. Of the 4539 subjects eligible for enrollment, 3428 subjects comprised the study group and 1111 subjects comprised the validation group.

Results: WBC counts were significantly different between subjects with and without MetS in both genders. Using the ROC curve, WBC cutoff values of 5.7 × 103/l in males and 5.0 × 103/l in females were associated with the increased risk of developing MetS (all p values

Conclusions: The association between WBC count and MetS was gender specific. A WBC cutoff value greater than 5.0 103/l may predict the development of MetS in elderly women.

Original languageEnglish
Pages (from-to)230-237
Number of pages8
JournalAging Male
Volume17
Issue number4
DOIs
Publication statusPublished - Dec 1 2014

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Leukocyte Count
Longitudinal Studies
Leukocytes
ROC Curve
Health

Keywords

  • Elderly
  • Longitudinal
  • Metabolic syndrome
  • Prediction
  • WBC

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Use of white blood cell counts to predict metabolic syndrome in the elderly : A 4 year longitudinal study. / Chao, Ting Ting; Hsieh, Chang Hsun; Lin, Jiunn Diann; Wu, Chung Ze; Hsu, Chun Hsien; Pei, Dee; Chen, Yen Lin; Liang, Yao Jen; Chang, Jin Biou.

In: Aging Male, Vol. 17, No. 4, 01.12.2014, p. 230-237.

Research output: Contribution to journalArticle

Chao, Ting Ting ; Hsieh, Chang Hsun ; Lin, Jiunn Diann ; Wu, Chung Ze ; Hsu, Chun Hsien ; Pei, Dee ; Chen, Yen Lin ; Liang, Yao Jen ; Chang, Jin Biou. / Use of white blood cell counts to predict metabolic syndrome in the elderly : A 4 year longitudinal study. In: Aging Male. 2014 ; Vol. 17, No. 4. pp. 230-237.
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