Use of soluble triggering receptor expressed on myeloid cells-1 in non-tuberculous mycobacterial lung disease

C. C. Shu, L. N. Lee, M. F. Wu, C. H. Lee, J. T. Wang, Jann Yuan Wang, C. J. Yu, L. N. Lee, P. C. Yang, W. J. Su, H. C. Lai, V. C. Wu, M. C. Yu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

BACKGROUND: Serum biomarkers are rarely studied in patients with non-tuberculous mycobacterial lung disease (NTM-LD). OBJECTIVE: To investigate the role of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and other inflammatory markers in NTM-LD. DESIGN: From April 2009 to March 2010, patients with NTM culture-positive respiratory specimens who were clinically and radiographically suspected of NTM-LD were evaluated for serum levels of sTREM-1, C-reactive protein, procalcitonin and interferon-gamma. RESULTS: Of the 86 patients enrolled, 60 fulfilled the diagnosis of NTM-LD. Using the receiver-operating characteristics curve analysis, serum sTREM-1 had the highest discriminative power for NTM-LD and colonisation (area under the curve = 0.714). Using a cut-off value of 180 pg/ml, the sensitivity and specificity of sTREM-1 were respectively 58% and 89%. Logistic regression analysis revealed that Mycobacterium avium complex, M. kansasii, positive sputum acid-fast smear and higher serum sTREM-1 level were independent risk factors for NTM-LD. Age ≥65 years and higher serum sTREM-1 level were associated with worse 6-month survival. CONCLUSION: In patients with respiratory specimens that are culture-positive for NTM with clinical suspicion of NTM-LD, serum sTREM-1 level measurements may be helpful in diagnosing and predicting outcome for NTM-LD.

Original languageEnglish
Pages (from-to)1415-1420
Number of pages6
JournalInternational Journal of Tuberculosis and Lung Disease
Volume15
Issue number10
DOIs
Publication statusPublished - Oct 2011
Externally publishedYes

Fingerprint

Myeloid Cells
Lung Diseases
Serum
Mycobacterium avium Complex
Calcitonin
Sputum
ROC Curve
C-Reactive Protein
Interferon-gamma
Area Under Curve
Biomarkers
Logistic Models
Regression Analysis
Sensitivity and Specificity
Acids
Survival

Keywords

  • Colonisation
  • Lung disease
  • NTM
  • Procalcitonin
  • sTREM-1

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

Cite this

Use of soluble triggering receptor expressed on myeloid cells-1 in non-tuberculous mycobacterial lung disease. / Shu, C. C.; Lee, L. N.; Wu, M. F.; Lee, C. H.; Wang, J. T.; Wang, Jann Yuan; Yu, C. J.; Lee, L. N.; Yang, P. C.; Su, W. J.; Lai, H. C.; Wu, V. C.; Yu, M. C.

In: International Journal of Tuberculosis and Lung Disease, Vol. 15, No. 10, 10.2011, p. 1415-1420.

Research output: Contribution to journalArticle

Shu, C. C. ; Lee, L. N. ; Wu, M. F. ; Lee, C. H. ; Wang, J. T. ; Wang, Jann Yuan ; Yu, C. J. ; Lee, L. N. ; Yang, P. C. ; Su, W. J. ; Lai, H. C. ; Wu, V. C. ; Yu, M. C. / Use of soluble triggering receptor expressed on myeloid cells-1 in non-tuberculous mycobacterial lung disease. In: International Journal of Tuberculosis and Lung Disease. 2011 ; Vol. 15, No. 10. pp. 1415-1420.
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abstract = "BACKGROUND: Serum biomarkers are rarely studied in patients with non-tuberculous mycobacterial lung disease (NTM-LD). OBJECTIVE: To investigate the role of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and other inflammatory markers in NTM-LD. DESIGN: From April 2009 to March 2010, patients with NTM culture-positive respiratory specimens who were clinically and radiographically suspected of NTM-LD were evaluated for serum levels of sTREM-1, C-reactive protein, procalcitonin and interferon-gamma. RESULTS: Of the 86 patients enrolled, 60 fulfilled the diagnosis of NTM-LD. Using the receiver-operating characteristics curve analysis, serum sTREM-1 had the highest discriminative power for NTM-LD and colonisation (area under the curve = 0.714). Using a cut-off value of 180 pg/ml, the sensitivity and specificity of sTREM-1 were respectively 58{\%} and 89{\%}. Logistic regression analysis revealed that Mycobacterium avium complex, M. kansasii, positive sputum acid-fast smear and higher serum sTREM-1 level were independent risk factors for NTM-LD. Age ≥65 years and higher serum sTREM-1 level were associated with worse 6-month survival. CONCLUSION: In patients with respiratory specimens that are culture-positive for NTM with clinical suspicion of NTM-LD, serum sTREM-1 level measurements may be helpful in diagnosing and predicting outcome for NTM-LD.",
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AU - Lee, L. N.

AU - Wu, M. F.

AU - Lee, C. H.

AU - Wang, J. T.

AU - Wang, Jann Yuan

AU - Yu, C. J.

AU - Lee, L. N.

AU - Yang, P. C.

AU - Su, W. J.

AU - Lai, H. C.

AU - Wu, V. C.

AU - Yu, M. C.

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N2 - BACKGROUND: Serum biomarkers are rarely studied in patients with non-tuberculous mycobacterial lung disease (NTM-LD). OBJECTIVE: To investigate the role of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and other inflammatory markers in NTM-LD. DESIGN: From April 2009 to March 2010, patients with NTM culture-positive respiratory specimens who were clinically and radiographically suspected of NTM-LD were evaluated for serum levels of sTREM-1, C-reactive protein, procalcitonin and interferon-gamma. RESULTS: Of the 86 patients enrolled, 60 fulfilled the diagnosis of NTM-LD. Using the receiver-operating characteristics curve analysis, serum sTREM-1 had the highest discriminative power for NTM-LD and colonisation (area under the curve = 0.714). Using a cut-off value of 180 pg/ml, the sensitivity and specificity of sTREM-1 were respectively 58% and 89%. Logistic regression analysis revealed that Mycobacterium avium complex, M. kansasii, positive sputum acid-fast smear and higher serum sTREM-1 level were independent risk factors for NTM-LD. Age ≥65 years and higher serum sTREM-1 level were associated with worse 6-month survival. CONCLUSION: In patients with respiratory specimens that are culture-positive for NTM with clinical suspicion of NTM-LD, serum sTREM-1 level measurements may be helpful in diagnosing and predicting outcome for NTM-LD.

AB - BACKGROUND: Serum biomarkers are rarely studied in patients with non-tuberculous mycobacterial lung disease (NTM-LD). OBJECTIVE: To investigate the role of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and other inflammatory markers in NTM-LD. DESIGN: From April 2009 to March 2010, patients with NTM culture-positive respiratory specimens who were clinically and radiographically suspected of NTM-LD were evaluated for serum levels of sTREM-1, C-reactive protein, procalcitonin and interferon-gamma. RESULTS: Of the 86 patients enrolled, 60 fulfilled the diagnosis of NTM-LD. Using the receiver-operating characteristics curve analysis, serum sTREM-1 had the highest discriminative power for NTM-LD and colonisation (area under the curve = 0.714). Using a cut-off value of 180 pg/ml, the sensitivity and specificity of sTREM-1 were respectively 58% and 89%. Logistic regression analysis revealed that Mycobacterium avium complex, M. kansasii, positive sputum acid-fast smear and higher serum sTREM-1 level were independent risk factors for NTM-LD. Age ≥65 years and higher serum sTREM-1 level were associated with worse 6-month survival. CONCLUSION: In patients with respiratory specimens that are culture-positive for NTM with clinical suspicion of NTM-LD, serum sTREM-1 level measurements may be helpful in diagnosing and predicting outcome for NTM-LD.

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