Use of Older Red Blood Cells in Low Birth Weight Infants

Research output: Contribution to journalArticle

Abstract

Very low birth weight infants, particularly those of less thon 30 weeks’ gestation, usually require multiple red blood cell transfusions. Exposure to blood from multiple donors increases the potential for adverse effects, particularly transfusion-associated infections. In this study we hypothesized that using older packed red blood cell (PRBC) transfusions would not significantly alter acid base and serum electrolytes, but would decrease exposure to blood from mulitiple donors. The blood was preserved in citrate phosphate dextrose adenine (CPDA) solution and provided as a main unit with one empty satellite bag so that two separate transfusions can be given before the expiry date 35 day later. The infants’ arterial blood gas, hemoglobin, plasma sodium, potassium, and calcium were measured just before and 1-2 hours ofter each transfusion. Seven infants (mean±SE, birth weight 1186±103 gm, gestational age 29.6±0.7 weeks) received 18 transfusions of 15 Ml/kg of PRBC over 3 hours. The median (range) age of the PRBC transfused was 8 days (1-27 days). Following transfusion, there was a significant increase in hemoglobin (10.5±0.3 to 13.3±0.2 gm/dL) and calcium concentrations (2.20±0.08 to 2.34±0.06 mmol/L). Acid base, plasma sodium, and potassium concentrations were not significantly different. Vital signs remained stable during the transfusions. We conclude that CPDA preserved older PRBC may be safe for use in premature infants and they can be used to decrease donor exposure risk for infants requiring multiple blood transfusions.
Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalTzu Chi Medical Journal
Volume8
Issue number1
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Low Birth Weight Infant
Erythrocyte Transfusion
Erythrocytes
Adenine
Blood Donors
Potassium
Hemoglobins
Sodium
Plasma Gases
Calcium
Very Low Birth Weight Infant
Acids
Vital Signs
Birth Weight
Premature Infants
Blood Transfusion
Electrolytes
Gestational Age
Tissue Donors
Pregnancy

Keywords

  • 輸血
  • 低體重兒
  • 捐血者暴露
  • blood transfusion
  • low birth weight infant
  • donor exposure

Cite this

Use of Older Red Blood Cells in Low Birth Weight Infants. / 陳中明(Chung-Ming Chen).

In: Tzu Chi Medical Journal, Vol. 8, No. 1, 1996, p. 13-19.

Research output: Contribution to journalArticle

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KW - 輸血

KW - 低體重兒

KW - 捐血者暴露

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KW - low birth weight infant

KW - donor exposure

M3 - Article

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