Use of lipid-lowering agents is not associated with improved outcomes for tuberculosis patients on standard-course therapy: A population-based cohort study

Yung Tai Chen, Shu Chen Kuo, Pei Wen Chao, Yea Yuan Chang

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Abstract

Objectives Animal and ex vitro studies suggested lipid-lowering agents (LLAs) may be used as an adjunct to standard anti- tuberculosis (TB) treatment. No human study has been conducted to date. Using the Taiwan National Health Insurance Research Database (NHIRD), the current population-based cohort study sought to examine the association between use of LLAs and outcomes of patients with pulmonary TB receiving anti-TB treatment. Methods Using a NHIRD from 2003 to 2010, this population-based cohort study retrospectively examined the association between LLAs (statins or fibrates) and the outcomes of patients with pulmonary TB receiving anti-TB treatment. Results A total of 1452 adult patients newly diagnosed with pulmonary TB during the study period were identified and compared with 5808 matched patients. In the LAA cohort, 1258 received statin, and 295 received fibrate. Compared with patients who did not take LLA, patients who took oral LLAs had similar incidence of treatment completion at 9, 12, and 24 months. Conclusions Neither statins nor fibrates provide clinical benefit superior to that achieved with standard anti-tuberculosis treatment. Future clinical trials should investigate the effects of statins and fibrates on short-course standard anti-TB therapy.

Original languageEnglish
Article numbere0210479
JournalPLoS One
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 1 2019

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antilipemic agents
Fibric Acids
Hydroxymethylglutaryl-CoA Reductase Inhibitors
cohort studies
tuberculosis
Tuberculosis
Cohort Studies
Lipids
therapeutics
Health insurance
Pulmonary Tuberculosis
Population
National Health Programs
Proxy
health insurance
lungs
Therapeutics
Databases
Taiwan
Research

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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Use of lipid-lowering agents is not associated with improved outcomes for tuberculosis patients on standard-course therapy : A population-based cohort study. / Chen, Yung Tai; Kuo, Shu Chen; Chao, Pei Wen; Chang, Yea Yuan.

In: PLoS One, Vol. 14, No. 1, e0210479, 01.01.2019.

Research output: Contribution to journalArticle

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