Use of fluorine-18 fluorodeoxyglucose positron emission tomography in the detection of thymoma: A preliminary report

Ren Shyan Liu, Shin Hwa Yeh, Min Hsiung Huang, Liang Shun Wang, Lee Shing Chu, Chen Pei Chang, Yum Kung Chu, Liang Chi Wu

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Thymomas are lacking in malignant cytological features. Their staging is defined by the invasiveness of the tumour. This study aimed to analyse the uptake patterns of fluorine-18 fluorodeoxyglucose (FDG) in thymomas of different stages. FDG positron emission tomography (PET) scan was performed in 12 patients suspected of having thymoma and in nine controls. Qualitative visual interpretation was used to detect the foci with FDG uptake higher than that of normal mediastinum. Tumour/lung ratio (TLR) was calculated from the counts of ROIs over the mass and over comparable normal lung tissue in thymoma patients. Mediastinum/lung ratio (MLR) was calculated from the counts of ROIs over the anterior mediastinum and lung in controls. The PET scan patterns of distribution of foci with FDG uptake and TLRs were correlated with the computed tomography (CT) or magnetic resonance imaging (MRI) findings, and staging of the thymomas. Thymectomy was performed in ten patients and thoracoscopy was done in two patients. The results revealed ten thymomas (two stage I tumours, two stage II, four stage III and two stage IV, according to the Masaoka classification), and two cases of thymic hyperplasia associated with myasthenia gravis. Myasthenia gravis was also noted in four thymoma patients. FDG studies showed (a) diffuse uptake in the widened anterior mediastinum in patients with thymic hyperplasia, (b) confined focal FDG uptake in the non-invasive or less invasive, stage I and II thymomas, and (c) multiple discrete foci of FDG uptake in the mediastinum and thoracic structures in stage III and IV advanced invasive thymomas. The thymomas had the highest TLRs, followed by the TLRs of thymic hyperplasia and the MLRs of control subjects (P

Original languageEnglish
Pages (from-to)1402-1407
Number of pages6
JournalEuropean Journal Of Nuclear Medicine
Volume22
Issue number12
DOIs
Publication statusPublished - Dec 1995
Externally publishedYes

Fingerprint

Thymoma
Fluorodeoxyglucose F18
Positron-Emission Tomography
Mediastinum
Thymus Hyperplasia
Lung
Myasthenia Gravis
Neoplasms
Thoracoscopy
Thymectomy
Thorax
Tomography
Magnetic Resonance Imaging

Keywords

  • Fluorine-18-fluorodeoxyglucose
  • Positron emission tomography
  • Thymic hyperplasia
  • Thymoma
  • Thymus

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Use of fluorine-18 fluorodeoxyglucose positron emission tomography in the detection of thymoma : A preliminary report. / Liu, Ren Shyan; Yeh, Shin Hwa; Huang, Min Hsiung; Wang, Liang Shun; Chu, Lee Shing; Chang, Chen Pei; Chu, Yum Kung; Wu, Liang Chi.

In: European Journal Of Nuclear Medicine, Vol. 22, No. 12, 12.1995, p. 1402-1407.

Research output: Contribution to journalArticle

Liu, Ren Shyan ; Yeh, Shin Hwa ; Huang, Min Hsiung ; Wang, Liang Shun ; Chu, Lee Shing ; Chang, Chen Pei ; Chu, Yum Kung ; Wu, Liang Chi. / Use of fluorine-18 fluorodeoxyglucose positron emission tomography in the detection of thymoma : A preliminary report. In: European Journal Of Nuclear Medicine. 1995 ; Vol. 22, No. 12. pp. 1402-1407.
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