Use of FDG-PET or PET/CT to detect recurrent colorectal cancer in patients with elevated CEA: A systematic review and meta-analysis

Yu Yu Lu, Jin Hua Chen, Chun Ru Chien, William Tzu Liang Chen, Shih Chuan Tsai, Wan Yu Lin, Chia Hung Kao

Research output: Contribution to journalArticle

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Abstract

Aim: The purpose of the present study was to conduct a systematic review and meta-analysis of the published literature to assess the diagnostic performance of FDG-PET or PET/CT in the detection of recurrent colorectal cancer (CRC) rising in patients with elevated CEA. Materials and methods: The authors conducted a systematic MEDLINE search of published articles. Two reviewers independently assessed the methodological quality of each study. We estimated pooled sensitivity and specificity and positive and negative likelihood ratios, and summary receiver-operating characteristic curves in the detection of recurrent CRC in patients with elevated CEA. Results: Eleven studies with a total of 510 patients met the inclusion criteria. One hundred and six patients (106/510 = 20.8 %) had true-negative FDG-PET (PET/CT) results in detection of recurrent CRC when rising CEA. The pooled estimates of sensitivity and specificity and positive and negative likelihood ratios of FDG-PET in the detection of tumor recurrence in CRC patients with elevated CEA were 90.3 % (95 % CI, 85.5-94.0 %), 80.0 % (95 % CI, 67.0-89.6 %), 2.88 (95 % CI, 1.37-6.07), and 0.12 (95 % CI, 0.07-0.20), respectively. The pooled estimates of sensitivity and specificity and positive and negative likelihood ratios of FDG-PET/CT in the detection of tumor recurrence in CRC patients with elevated CEA were 94.1 % (95 % CI, 89.4-97.1 %), 77.2 % (95 % CI, 66.4-85.9 %), 4.70 (95 % CI, 0.82-12.13), and 0.06 (95 % CI, 0.03-0.13), respectively. Conclusions: Whole-body FDG-PET and PET/CT are valuable imaging tools for the assessment of patients with suspected CRC tumor recurrence based on the increase of CEA.

Original languageEnglish
Pages (from-to)1039-1047
Number of pages9
JournalInternational Journal of Colorectal Disease
Volume28
Issue number8
DOIs
Publication statusPublished - Aug 2013
Externally publishedYes

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Meta-Analysis
Colorectal Neoplasms
Recurrence
Sensitivity and Specificity
MEDLINE
ROC Curve
Neoplasms

Keywords

  • Carcinoembryonic antigen
  • FDG-PET
  • Meta-analysis
  • PET/CT
  • Systematic review

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Use of FDG-PET or PET/CT to detect recurrent colorectal cancer in patients with elevated CEA : A systematic review and meta-analysis. / Lu, Yu Yu; Chen, Jin Hua; Chien, Chun Ru; Chen, William Tzu Liang; Tsai, Shih Chuan; Lin, Wan Yu; Kao, Chia Hung.

In: International Journal of Colorectal Disease, Vol. 28, No. 8, 08.2013, p. 1039-1047.

Research output: Contribution to journalArticle

Lu, Yu Yu ; Chen, Jin Hua ; Chien, Chun Ru ; Chen, William Tzu Liang ; Tsai, Shih Chuan ; Lin, Wan Yu ; Kao, Chia Hung. / Use of FDG-PET or PET/CT to detect recurrent colorectal cancer in patients with elevated CEA : A systematic review and meta-analysis. In: International Journal of Colorectal Disease. 2013 ; Vol. 28, No. 8. pp. 1039-1047.
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abstract = "Aim: The purpose of the present study was to conduct a systematic review and meta-analysis of the published literature to assess the diagnostic performance of FDG-PET or PET/CT in the detection of recurrent colorectal cancer (CRC) rising in patients with elevated CEA. Materials and methods: The authors conducted a systematic MEDLINE search of published articles. Two reviewers independently assessed the methodological quality of each study. We estimated pooled sensitivity and specificity and positive and negative likelihood ratios, and summary receiver-operating characteristic curves in the detection of recurrent CRC in patients with elevated CEA. Results: Eleven studies with a total of 510 patients met the inclusion criteria. One hundred and six patients (106/510 = 20.8 {\%}) had true-negative FDG-PET (PET/CT) results in detection of recurrent CRC when rising CEA. The pooled estimates of sensitivity and specificity and positive and negative likelihood ratios of FDG-PET in the detection of tumor recurrence in CRC patients with elevated CEA were 90.3 {\%} (95 {\%} CI, 85.5-94.0 {\%}), 80.0 {\%} (95 {\%} CI, 67.0-89.6 {\%}), 2.88 (95 {\%} CI, 1.37-6.07), and 0.12 (95 {\%} CI, 0.07-0.20), respectively. The pooled estimates of sensitivity and specificity and positive and negative likelihood ratios of FDG-PET/CT in the detection of tumor recurrence in CRC patients with elevated CEA were 94.1 {\%} (95 {\%} CI, 89.4-97.1 {\%}), 77.2 {\%} (95 {\%} CI, 66.4-85.9 {\%}), 4.70 (95 {\%} CI, 0.82-12.13), and 0.06 (95 {\%} CI, 0.03-0.13), respectively. Conclusions: Whole-body FDG-PET and PET/CT are valuable imaging tools for the assessment of patients with suspected CRC tumor recurrence based on the increase of CEA.",
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T1 - Use of FDG-PET or PET/CT to detect recurrent colorectal cancer in patients with elevated CEA

T2 - A systematic review and meta-analysis

AU - Lu, Yu Yu

AU - Chen, Jin Hua

AU - Chien, Chun Ru

AU - Chen, William Tzu Liang

AU - Tsai, Shih Chuan

AU - Lin, Wan Yu

AU - Kao, Chia Hung

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N2 - Aim: The purpose of the present study was to conduct a systematic review and meta-analysis of the published literature to assess the diagnostic performance of FDG-PET or PET/CT in the detection of recurrent colorectal cancer (CRC) rising in patients with elevated CEA. Materials and methods: The authors conducted a systematic MEDLINE search of published articles. Two reviewers independently assessed the methodological quality of each study. We estimated pooled sensitivity and specificity and positive and negative likelihood ratios, and summary receiver-operating characteristic curves in the detection of recurrent CRC in patients with elevated CEA. Results: Eleven studies with a total of 510 patients met the inclusion criteria. One hundred and six patients (106/510 = 20.8 %) had true-negative FDG-PET (PET/CT) results in detection of recurrent CRC when rising CEA. The pooled estimates of sensitivity and specificity and positive and negative likelihood ratios of FDG-PET in the detection of tumor recurrence in CRC patients with elevated CEA were 90.3 % (95 % CI, 85.5-94.0 %), 80.0 % (95 % CI, 67.0-89.6 %), 2.88 (95 % CI, 1.37-6.07), and 0.12 (95 % CI, 0.07-0.20), respectively. The pooled estimates of sensitivity and specificity and positive and negative likelihood ratios of FDG-PET/CT in the detection of tumor recurrence in CRC patients with elevated CEA were 94.1 % (95 % CI, 89.4-97.1 %), 77.2 % (95 % CI, 66.4-85.9 %), 4.70 (95 % CI, 0.82-12.13), and 0.06 (95 % CI, 0.03-0.13), respectively. Conclusions: Whole-body FDG-PET and PET/CT are valuable imaging tools for the assessment of patients with suspected CRC tumor recurrence based on the increase of CEA.

AB - Aim: The purpose of the present study was to conduct a systematic review and meta-analysis of the published literature to assess the diagnostic performance of FDG-PET or PET/CT in the detection of recurrent colorectal cancer (CRC) rising in patients with elevated CEA. Materials and methods: The authors conducted a systematic MEDLINE search of published articles. Two reviewers independently assessed the methodological quality of each study. We estimated pooled sensitivity and specificity and positive and negative likelihood ratios, and summary receiver-operating characteristic curves in the detection of recurrent CRC in patients with elevated CEA. Results: Eleven studies with a total of 510 patients met the inclusion criteria. One hundred and six patients (106/510 = 20.8 %) had true-negative FDG-PET (PET/CT) results in detection of recurrent CRC when rising CEA. The pooled estimates of sensitivity and specificity and positive and negative likelihood ratios of FDG-PET in the detection of tumor recurrence in CRC patients with elevated CEA were 90.3 % (95 % CI, 85.5-94.0 %), 80.0 % (95 % CI, 67.0-89.6 %), 2.88 (95 % CI, 1.37-6.07), and 0.12 (95 % CI, 0.07-0.20), respectively. The pooled estimates of sensitivity and specificity and positive and negative likelihood ratios of FDG-PET/CT in the detection of tumor recurrence in CRC patients with elevated CEA were 94.1 % (95 % CI, 89.4-97.1 %), 77.2 % (95 % CI, 66.4-85.9 %), 4.70 (95 % CI, 0.82-12.13), and 0.06 (95 % CI, 0.03-0.13), respectively. Conclusions: Whole-body FDG-PET and PET/CT are valuable imaging tools for the assessment of patients with suspected CRC tumor recurrence based on the increase of CEA.

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KW - PET/CT

KW - Systematic review

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