Use of Atosiban in a Twin Pregnancy With Extremely Preterm Premature Rupture in the Membrane of one Twin

A Case Report and Literature Review

Ming Yih Wu, Shee Uan Chen, Chien Nan Lee, Hong Nerng Ho, Y. S. Yang Yu-Shih

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: Pregnancies with extremely preterm premature rupture of membranes (EPPROM), especially before 20 weeks of gestation, are usually considered to be a termination of pregnancy. By improvement of obstetric and neonatal care, we can prolong the pregnancy across the threshold of survival by aggressive tocolysis. Case Report: Using intrauterine insemination, a 32-year-old woman became pregnant with twins (first pregnancy). Threatened abortion occured since 9 weeks of gestation and EPPROM of the upper twin was noted at 18 weeks. Massive vaginal bleeding and vigorous uterine contractions occurred at 22 weeks. Poor control of preterm labor occurred using ritodrine and MgSO 4 . Atosiban was applied to calm uterine activities. After discontinuation of atosiban at 30 weeks, the uterine contractions became severe again and an emergency cesarean section was performed to deliver two live, premature babies weighing 1,518 g and 830 g, respectively. Twin A was healthy, weighing 2,030 g at 35 days after birth and subsequently discharged. The smaller twin B was dependent on continuous positive airway pressure and died of pulmonary infection 120 days after birth. Conclusion: Comparing to other tocolytic agents, Atosiban has few side effects and assisted in prolonging a pregnancy involving twins that experienced EPPROM.

Original languageEnglish
Pages (from-to)495-499
Number of pages5
JournalTaiwanese Journal of Obstetrics and Gynecology
Volume49
Issue number4
DOIs
Publication statusPublished - Dec 1 2010

Fingerprint

Premature Rupture Fetal Membranes
Ritodrine
Tocolytic Agents
Tocolysis
Vasotocin
Magnesium Sulfate
Multiple Pregnancy
Assisted Reproductive Techniques
Twin Pregnancy
Fetal Growth Retardation
Premature Birth
Premature Infants
Gestational Age
Newborn Infant
Pregnancy
Uterine Contraction
Obstetrics
Threatened Abortion
Parturition
Continuous Positive Airway Pressure

Keywords

  • Atosiban
  • EPPROM
  • Twin pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Use of Atosiban in a Twin Pregnancy With Extremely Preterm Premature Rupture in the Membrane of one Twin : A Case Report and Literature Review. / Wu, Ming Yih; Chen, Shee Uan; Lee, Chien Nan; Ho, Hong Nerng; Yang Yu-Shih, Y. S.

In: Taiwanese Journal of Obstetrics and Gynecology, Vol. 49, No. 4, 01.12.2010, p. 495-499.

Research output: Contribution to journalArticle

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