Urothelial carcinoma of the urinary bladder in young adults - Clinical experience at Taipei Veterans General Hospital

Yu Ching Wen, Junne Yih Kuo, Kuang Kuo Chen, Alex T L Lin, Yen Hwa Chang, Yen Shen Hsu, Luke S. Chang

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background: The clinical behavior and prognosis of bladder cancer in young patients is not well defined. The aim of this study was, therefore, to evaluate the clinical behavior, pathologic characteristics and prognosis of urothelial carcinoma of the urinary bladder in young adults. Methods: We retrospectively reviewed records from 30 young patients (23 males, 7 females; age ≤ 40 years) with urothelial carcinoma of the urinary bladder who had been treated in our hospital between May 1990 and October 2003. Data were analyzed by the Kaplan-Meier method to assess disease recurrence and survival. Results: The mean age at diagnosis was 34.3 ± 5 years (range, 22-40 years). Fifteen patients presented with pTa, 9 with pT1, 4 with pT2, 1 with pT3, and 1 with pT4. Twenty-six patients (87.2%) had low-grade bladder cancer, and the other 4 had high-grade disease. The most frequent initial presenting symptom was gross hematuria. The mean postoperative follow-up period was 72.8 months (range, 4-149 months). Fifty percent of superficial bladder cancers recurred a mean of 10.7 months (range, 3-68 months) after operation. One patient died from invasive bladder cancer after radical cystectomy, and 1 died from superficial bladder cancer due to tumor progression. The 5-year cancer-specific survival rate was 95.2% for superficial cancer and 83.3% for invasive cancer. The overall survival rate was 93.3%. Conclusion: Urothelial carcinoma of the urinary bladder in young adults is usually associated with low grade and low stage. Invasive bladder cancer had no worse a survival rate than superficial bladder cancer.

Original languageEnglish
Pages (from-to)272-275
Number of pages4
JournalJournal of the Chinese Medical Association
Volume68
Issue number6
Publication statusPublished - Jun 2005
Externally publishedYes

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Veterans Hospitals
Urinary Bladder Neoplasms
General Hospitals
Young Adult
Urinary Bladder
Carcinoma
Survival Rate
Neoplasms
Cystectomy
Hematuria
Recurrence
Survival

Keywords

  • Gross hematuria
  • Urinary bladder
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Urothelial carcinoma of the urinary bladder in young adults - Clinical experience at Taipei Veterans General Hospital. / Wen, Yu Ching; Kuo, Junne Yih; Chen, Kuang Kuo; Lin, Alex T L; Chang, Yen Hwa; Hsu, Yen Shen; Chang, Luke S.

In: Journal of the Chinese Medical Association, Vol. 68, No. 6, 06.2005, p. 272-275.

Research output: Contribution to journalArticle

Wen, Yu Ching ; Kuo, Junne Yih ; Chen, Kuang Kuo ; Lin, Alex T L ; Chang, Yen Hwa ; Hsu, Yen Shen ; Chang, Luke S. / Urothelial carcinoma of the urinary bladder in young adults - Clinical experience at Taipei Veterans General Hospital. In: Journal of the Chinese Medical Association. 2005 ; Vol. 68, No. 6. pp. 272-275.
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N2 - Background: The clinical behavior and prognosis of bladder cancer in young patients is not well defined. The aim of this study was, therefore, to evaluate the clinical behavior, pathologic characteristics and prognosis of urothelial carcinoma of the urinary bladder in young adults. Methods: We retrospectively reviewed records from 30 young patients (23 males, 7 females; age ≤ 40 years) with urothelial carcinoma of the urinary bladder who had been treated in our hospital between May 1990 and October 2003. Data were analyzed by the Kaplan-Meier method to assess disease recurrence and survival. Results: The mean age at diagnosis was 34.3 ± 5 years (range, 22-40 years). Fifteen patients presented with pTa, 9 with pT1, 4 with pT2, 1 with pT3, and 1 with pT4. Twenty-six patients (87.2%) had low-grade bladder cancer, and the other 4 had high-grade disease. The most frequent initial presenting symptom was gross hematuria. The mean postoperative follow-up period was 72.8 months (range, 4-149 months). Fifty percent of superficial bladder cancers recurred a mean of 10.7 months (range, 3-68 months) after operation. One patient died from invasive bladder cancer after radical cystectomy, and 1 died from superficial bladder cancer due to tumor progression. The 5-year cancer-specific survival rate was 95.2% for superficial cancer and 83.3% for invasive cancer. The overall survival rate was 93.3%. Conclusion: Urothelial carcinoma of the urinary bladder in young adults is usually associated with low grade and low stage. Invasive bladder cancer had no worse a survival rate than superficial bladder cancer.

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