Urinary total arsenic and 8-hydroxydeoxyguanosine are associated with renal cell carcinoma in an area without obvious arsenic exposure

Chao Yuan Huang, Chien Tien Su, Chi Jung Chung, Yeong Shiau Pu, Jan Show Chu, Hsiu Yuan Yang, Chia Chang Wu, Yu Mei Hsueh

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

8-Hydroxydeoxyguanosine (8-OHdG) is one of the most reliable and abundant markers of DNA damage. The study was designed to explore the relationship between urinary 8-OHdG and renal cell carcinoma (RCC) and to investigate whether individuals with a high level of 8-OHdG would have a modified odds ratio (OR) of arsenic-related RCC. This case-control study was conducted with 132 RCC patients and 245 age- and sex-matched controls from a hospital-based pool between November 2006 and May 2009. Pathological verification of RCC was completed by image-guided biopsy or surgical resection of renal tumors. Urinary 8-OHdG levels were determined using liquid chromatography with tandem mass spectrometry (LC-MS/MS). Concentrations of urinary arsenic species, including inorganic arsenic, monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA), were determined by a high performance liquid chromatography-linked hydride generator and atomic absorption spectrometry. Level of urinary 8-OHdG was significantly associated with the OR of RCC in a dose-response relationship after multivariate adjustment. Urinary 8-OHdG was significantly related to urinary total arsenic. The greatest OR (3.50) was seen in the individuals with high urinary 8-OHdG and high urinary total arsenic. A trend test indicated that the OR of RCC was increased with one of these factors and was further increased with both (p=0.002). In conclusion, higher urinary 8-OHdG was a strong predictor of the RCC. High levels of 8-OHdG combined with urinary total arsenic might be indicative of arsenic-induced RCC.

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalToxicology and Applied Pharmacology
Volume262
Issue number3
DOIs
Publication statusPublished - Aug 1 2012

Keywords

  • 8-Hydroxydeoxyguanosine 5'-monophosphate
  • Arsenic
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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