Urinary nitric oxide metabolite changes in spontaneous and induced onset active labor

Da Chung Chen, Chih Hung Ku, Yi Chun Huang, Chi Huang Chen, Gwo Jang Wu

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background. The aim of this prospective, randomized study was to investigate the changes in urinary nitric oxide (NO) metabolite between the latent and the active phases of spontaneous and either prostaglandin E 1 (PGE1) or prostaglandin E2 (PGE 2)-induced labors. Methods. Eighty-eight singleton pregnant women at 36-41+ weeks' gestation without signs of fetal distress were enrolled. The first group consisted of 29 pregnant women in whom labor was induced by PGE1 applied intravaginally. The second group consisted of 29 pregnant women with labor induced by PGE2 applied intracervically. The third group consisted of 30 women, who had spontaneous active labor. Clinical data of the three groups were assessed as labor progressed. Results. Urinary nitric oxide/creatinine (U NO/Cr) decreased significantly after the onset of active labor in all three groups (p <0.005), with the percentage decline of 42.2%, 28.6% and 10.1%, respectively. The magnitude of the difference in decline in U NO/Cr after active labor between the PGE1-induced and the spontaneous labor group was significantly reduced (p = 0.0047) after adjustment for potential confounders using the generalized estimating equations test (GEE). The duration of the latent phase was significantly shortened in the PGE1-induced group as compared with the spontaneous labor group (p <0.01). Conclusions. Decreased U NO/Cr may facilitate transition from the latent to the active phase either in spontaneous or induced labors. Our results indicate that U NO/Cr can serve as an easily obtained marker for use in controlling myometrial contractility and cervical ripening at the onset of active labor. The nitric oxide system is present in the human uterus and may contribute to uterine quiescence during pregnancy and show down-regulation in U NO/Cr at the initiation of active labor.

Original languageEnglish
Pages (from-to)641-646
Number of pages6
JournalActa Obstetricia et Gynecologica Scandinavica
Volume83
Issue number7
DOIs
Publication statusPublished - Jul 2004
Externally publishedYes

Fingerprint

Labor Onset
Induced Labor
Nitric Oxide
Creatinine
Prostaglandins E
Pregnant Women
Dinoprostone
Cervical Ripening
Pregnancy
Fetal Distress
Uterus
Down-Regulation
Prospective Studies

Keywords

  • Active labor
  • Nitric oxide
  • Prostaglandin

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Urinary nitric oxide metabolite changes in spontaneous and induced onset active labor. / Chen, Da Chung; Ku, Chih Hung; Huang, Yi Chun; Chen, Chi Huang; Wu, Gwo Jang.

In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 83, No. 7, 07.2004, p. 641-646.

Research output: Contribution to journalArticle

Chen, Da Chung ; Ku, Chih Hung ; Huang, Yi Chun ; Chen, Chi Huang ; Wu, Gwo Jang. / Urinary nitric oxide metabolite changes in spontaneous and induced onset active labor. In: Acta Obstetricia et Gynecologica Scandinavica. 2004 ; Vol. 83, No. 7. pp. 641-646.
@article{4acec2d32f494301b56a831aff782656,
title = "Urinary nitric oxide metabolite changes in spontaneous and induced onset active labor",
abstract = "Background. The aim of this prospective, randomized study was to investigate the changes in urinary nitric oxide (NO) metabolite between the latent and the active phases of spontaneous and either prostaglandin E 1 (PGE1) or prostaglandin E2 (PGE 2)-induced labors. Methods. Eighty-eight singleton pregnant women at 36-41+ weeks' gestation without signs of fetal distress were enrolled. The first group consisted of 29 pregnant women in whom labor was induced by PGE1 applied intravaginally. The second group consisted of 29 pregnant women with labor induced by PGE2 applied intracervically. The third group consisted of 30 women, who had spontaneous active labor. Clinical data of the three groups were assessed as labor progressed. Results. Urinary nitric oxide/creatinine (U NO/Cr) decreased significantly after the onset of active labor in all three groups (p <0.005), with the percentage decline of 42.2{\%}, 28.6{\%} and 10.1{\%}, respectively. The magnitude of the difference in decline in U NO/Cr after active labor between the PGE1-induced and the spontaneous labor group was significantly reduced (p = 0.0047) after adjustment for potential confounders using the generalized estimating equations test (GEE). The duration of the latent phase was significantly shortened in the PGE1-induced group as compared with the spontaneous labor group (p <0.01). Conclusions. Decreased U NO/Cr may facilitate transition from the latent to the active phase either in spontaneous or induced labors. Our results indicate that U NO/Cr can serve as an easily obtained marker for use in controlling myometrial contractility and cervical ripening at the onset of active labor. The nitric oxide system is present in the human uterus and may contribute to uterine quiescence during pregnancy and show down-regulation in U NO/Cr at the initiation of active labor.",
keywords = "Active labor, Nitric oxide, Prostaglandin",
author = "Chen, {Da Chung} and Ku, {Chih Hung} and Huang, {Yi Chun} and Chen, {Chi Huang} and Wu, {Gwo Jang}",
year = "2004",
month = "7",
doi = "10.1111/j.0001-6349.2004.00448.x",
language = "English",
volume = "83",
pages = "641--646",
journal = "Acta Obstetricia et Gynecologica Scandinavica",
issn = "0001-6349",
publisher = "Wiley-Blackwell",
number = "7",

}

TY - JOUR

T1 - Urinary nitric oxide metabolite changes in spontaneous and induced onset active labor

AU - Chen, Da Chung

AU - Ku, Chih Hung

AU - Huang, Yi Chun

AU - Chen, Chi Huang

AU - Wu, Gwo Jang

PY - 2004/7

Y1 - 2004/7

N2 - Background. The aim of this prospective, randomized study was to investigate the changes in urinary nitric oxide (NO) metabolite between the latent and the active phases of spontaneous and either prostaglandin E 1 (PGE1) or prostaglandin E2 (PGE 2)-induced labors. Methods. Eighty-eight singleton pregnant women at 36-41+ weeks' gestation without signs of fetal distress were enrolled. The first group consisted of 29 pregnant women in whom labor was induced by PGE1 applied intravaginally. The second group consisted of 29 pregnant women with labor induced by PGE2 applied intracervically. The third group consisted of 30 women, who had spontaneous active labor. Clinical data of the three groups were assessed as labor progressed. Results. Urinary nitric oxide/creatinine (U NO/Cr) decreased significantly after the onset of active labor in all three groups (p <0.005), with the percentage decline of 42.2%, 28.6% and 10.1%, respectively. The magnitude of the difference in decline in U NO/Cr after active labor between the PGE1-induced and the spontaneous labor group was significantly reduced (p = 0.0047) after adjustment for potential confounders using the generalized estimating equations test (GEE). The duration of the latent phase was significantly shortened in the PGE1-induced group as compared with the spontaneous labor group (p <0.01). Conclusions. Decreased U NO/Cr may facilitate transition from the latent to the active phase either in spontaneous or induced labors. Our results indicate that U NO/Cr can serve as an easily obtained marker for use in controlling myometrial contractility and cervical ripening at the onset of active labor. The nitric oxide system is present in the human uterus and may contribute to uterine quiescence during pregnancy and show down-regulation in U NO/Cr at the initiation of active labor.

AB - Background. The aim of this prospective, randomized study was to investigate the changes in urinary nitric oxide (NO) metabolite between the latent and the active phases of spontaneous and either prostaglandin E 1 (PGE1) or prostaglandin E2 (PGE 2)-induced labors. Methods. Eighty-eight singleton pregnant women at 36-41+ weeks' gestation without signs of fetal distress were enrolled. The first group consisted of 29 pregnant women in whom labor was induced by PGE1 applied intravaginally. The second group consisted of 29 pregnant women with labor induced by PGE2 applied intracervically. The third group consisted of 30 women, who had spontaneous active labor. Clinical data of the three groups were assessed as labor progressed. Results. Urinary nitric oxide/creatinine (U NO/Cr) decreased significantly after the onset of active labor in all three groups (p <0.005), with the percentage decline of 42.2%, 28.6% and 10.1%, respectively. The magnitude of the difference in decline in U NO/Cr after active labor between the PGE1-induced and the spontaneous labor group was significantly reduced (p = 0.0047) after adjustment for potential confounders using the generalized estimating equations test (GEE). The duration of the latent phase was significantly shortened in the PGE1-induced group as compared with the spontaneous labor group (p <0.01). Conclusions. Decreased U NO/Cr may facilitate transition from the latent to the active phase either in spontaneous or induced labors. Our results indicate that U NO/Cr can serve as an easily obtained marker for use in controlling myometrial contractility and cervical ripening at the onset of active labor. The nitric oxide system is present in the human uterus and may contribute to uterine quiescence during pregnancy and show down-regulation in U NO/Cr at the initiation of active labor.

KW - Active labor

KW - Nitric oxide

KW - Prostaglandin

UR - http://www.scopus.com/inward/record.url?scp=3142692395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3142692395&partnerID=8YFLogxK

U2 - 10.1111/j.0001-6349.2004.00448.x

DO - 10.1111/j.0001-6349.2004.00448.x

M3 - Article

VL - 83

SP - 641

EP - 646

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

SN - 0001-6349

IS - 7

ER -