Urinary neutrophil gelatinase-associated lipocalin is associated with heavy metal exposure in welding workers

Kai Jen Chuang, Chih Hong Pan, Chien-Ling Su, Ching Huang Lai, Wen Yi Lin, Chih Ming Ma, Shu Chuan Ho, Mauo Ying Bien, Cheng Hsien Chen, Hsiao Chi Chuang

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Metals cause nephrotoxicity with acute and/or chronic exposure; however, few epidemiological studies have examined impacts of exposure to metal fumes on renal injury in welding workers. In total, 66 welding workers and 12 office workers were recruited from a shipyard located in southern Taiwan. Urine samples from each subject were collected at the beginning (baseline) and end of the work week (1-week exposure). Personal exposure to PM2.5 was measured. The 8-h mean PM2.5 was50.3 μg/m3 for welding workers and 27.4 μ g/m3 for office workers. iTRAQs coupled with LC-MS/MS were used to discover the pathways in response to welding PM2.5 in the urine, suggesting that extracellular matrix (ECM)-receptor interactions are a critical mechanism. ECM-receptor interaction-related biomarkers for renal injury, kidney injury molecule (KIM)-1 and neutrophil gelatinase-associated lipocalin (NGAL), were significantly elevated in welding workers post-exposure, as well as were urinary Al, Cr, Mn, Fe, Co, and Ni levels. NGAL was more significantly associated with Al (r = 0.737, p <0.001), Cr (r = 0.705, p <0.001), Fe (r = 0.709, p <0.001), and Ni (r = 0.657, p <0.001) than was KIM-1, suggesting that NGAL may be a urinary biomarker for welding PM 2.5 exposure. Nephrotoxicity (e.g., renal tubular injury) may be an emerging concern in occupational health.

Original languageEnglish
Article number18048
JournalScientific Reports
Volume5
DOIs
Publication statusPublished - Dec 17 2015

Fingerprint

Welding
Heavy Metals
Kidney
Wounds and Injuries
Biomarkers
Metals
Urine
Occupational Health
Taiwan
Lipocalin-2
Epidemiologic Studies

ASJC Scopus subject areas

  • General

Cite this

Urinary neutrophil gelatinase-associated lipocalin is associated with heavy metal exposure in welding workers. / Chuang, Kai Jen; Pan, Chih Hong; Su, Chien-Ling; Lai, Ching Huang; Lin, Wen Yi; Ma, Chih Ming; Ho, Shu Chuan; Bien, Mauo Ying; Chen, Cheng Hsien; Chuang, Hsiao Chi.

In: Scientific Reports, Vol. 5, 18048, 17.12.2015.

Research output: Contribution to journalArticle

@article{0957ecdff7ca46f88144826e47a3afca,
title = "Urinary neutrophil gelatinase-associated lipocalin is associated with heavy metal exposure in welding workers",
abstract = "Metals cause nephrotoxicity with acute and/or chronic exposure; however, few epidemiological studies have examined impacts of exposure to metal fumes on renal injury in welding workers. In total, 66 welding workers and 12 office workers were recruited from a shipyard located in southern Taiwan. Urine samples from each subject were collected at the beginning (baseline) and end of the work week (1-week exposure). Personal exposure to PM2.5 was measured. The 8-h mean PM2.5 was50.3 μg/m3 for welding workers and 27.4 μ g/m3 for office workers. iTRAQs coupled with LC-MS/MS were used to discover the pathways in response to welding PM2.5 in the urine, suggesting that extracellular matrix (ECM)-receptor interactions are a critical mechanism. ECM-receptor interaction-related biomarkers for renal injury, kidney injury molecule (KIM)-1 and neutrophil gelatinase-associated lipocalin (NGAL), were significantly elevated in welding workers post-exposure, as well as were urinary Al, Cr, Mn, Fe, Co, and Ni levels. NGAL was more significantly associated with Al (r = 0.737, p <0.001), Cr (r = 0.705, p <0.001), Fe (r = 0.709, p <0.001), and Ni (r = 0.657, p <0.001) than was KIM-1, suggesting that NGAL may be a urinary biomarker for welding PM 2.5 exposure. Nephrotoxicity (e.g., renal tubular injury) may be an emerging concern in occupational health.",
author = "Chuang, {Kai Jen} and Pan, {Chih Hong} and Chien-Ling Su and Lai, {Ching Huang} and Lin, {Wen Yi} and Ma, {Chih Ming} and Ho, {Shu Chuan} and Bien, {Mauo Ying} and Chen, {Cheng Hsien} and Chuang, {Hsiao Chi}",
year = "2015",
month = "12",
day = "17",
doi = "10.1038/srep18048",
language = "English",
volume = "5",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Urinary neutrophil gelatinase-associated lipocalin is associated with heavy metal exposure in welding workers

AU - Chuang, Kai Jen

AU - Pan, Chih Hong

AU - Su, Chien-Ling

AU - Lai, Ching Huang

AU - Lin, Wen Yi

AU - Ma, Chih Ming

AU - Ho, Shu Chuan

AU - Bien, Mauo Ying

AU - Chen, Cheng Hsien

AU - Chuang, Hsiao Chi

PY - 2015/12/17

Y1 - 2015/12/17

N2 - Metals cause nephrotoxicity with acute and/or chronic exposure; however, few epidemiological studies have examined impacts of exposure to metal fumes on renal injury in welding workers. In total, 66 welding workers and 12 office workers were recruited from a shipyard located in southern Taiwan. Urine samples from each subject were collected at the beginning (baseline) and end of the work week (1-week exposure). Personal exposure to PM2.5 was measured. The 8-h mean PM2.5 was50.3 μg/m3 for welding workers and 27.4 μ g/m3 for office workers. iTRAQs coupled with LC-MS/MS were used to discover the pathways in response to welding PM2.5 in the urine, suggesting that extracellular matrix (ECM)-receptor interactions are a critical mechanism. ECM-receptor interaction-related biomarkers for renal injury, kidney injury molecule (KIM)-1 and neutrophil gelatinase-associated lipocalin (NGAL), were significantly elevated in welding workers post-exposure, as well as were urinary Al, Cr, Mn, Fe, Co, and Ni levels. NGAL was more significantly associated with Al (r = 0.737, p <0.001), Cr (r = 0.705, p <0.001), Fe (r = 0.709, p <0.001), and Ni (r = 0.657, p <0.001) than was KIM-1, suggesting that NGAL may be a urinary biomarker for welding PM 2.5 exposure. Nephrotoxicity (e.g., renal tubular injury) may be an emerging concern in occupational health.

AB - Metals cause nephrotoxicity with acute and/or chronic exposure; however, few epidemiological studies have examined impacts of exposure to metal fumes on renal injury in welding workers. In total, 66 welding workers and 12 office workers were recruited from a shipyard located in southern Taiwan. Urine samples from each subject were collected at the beginning (baseline) and end of the work week (1-week exposure). Personal exposure to PM2.5 was measured. The 8-h mean PM2.5 was50.3 μg/m3 for welding workers and 27.4 μ g/m3 for office workers. iTRAQs coupled with LC-MS/MS were used to discover the pathways in response to welding PM2.5 in the urine, suggesting that extracellular matrix (ECM)-receptor interactions are a critical mechanism. ECM-receptor interaction-related biomarkers for renal injury, kidney injury molecule (KIM)-1 and neutrophil gelatinase-associated lipocalin (NGAL), were significantly elevated in welding workers post-exposure, as well as were urinary Al, Cr, Mn, Fe, Co, and Ni levels. NGAL was more significantly associated with Al (r = 0.737, p <0.001), Cr (r = 0.705, p <0.001), Fe (r = 0.709, p <0.001), and Ni (r = 0.657, p <0.001) than was KIM-1, suggesting that NGAL may be a urinary biomarker for welding PM 2.5 exposure. Nephrotoxicity (e.g., renal tubular injury) may be an emerging concern in occupational health.

UR - http://www.scopus.com/inward/record.url?scp=84950277675&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84950277675&partnerID=8YFLogxK

U2 - 10.1038/srep18048

DO - 10.1038/srep18048

M3 - Article

C2 - 26673824

AN - SCOPUS:84950277675

VL - 5

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 18048

ER -